Expression of hormone receptors in oropharyngeal squamous cell carcinoma

Hormone receptors play an important role in many types of cancers. Alongside factors associated with human papillomavirus (HPV) infection, hormonal receptors may impact the tumorigenesis of oropharyngeal cancer. This study consists of 199 consecutive oropharyngeal squamous cell carcinoma (OPSCC) patients diagnosed and treated with a curative intent. We examined androgen (AR), estrogen (ER; both alpha and beta), and progesterone receptor (PR) expressions using immunohistochemistry comparing tumor and patient characteristics. AR was expressed in 16%, PR in 27% and ER-beta in 63% of the tumors. HPV- and p16-positive tumors expressed more AR and less PR than their negative counterparts. High PR expression was associated with poor disease-specific and locoregional recurrence-free survival. AR, PR, and ER-beta are expressed in OPSCC, and AR and PR expressions are associated with HPV and p16 status. Furthermore, PR appears to have prognostic significance. This may allow us to investigate the role of anti-hormone receptors in the treatment of OPSCC.Peer reviewe

The communicative functions of final rises in Finnish intonation

This paper considers the communicative function of final rises in Finnishconversational talk between pairs of teenage girls. Final rises are fairly common,occurring approximately twice a minute, predominantly on declaratives and in nar-rativesequences. We briefly consider the interplay between voice quality (known tobe a marker of transition relevance) and rising intonation in Finnish. We argue that innarrative sequences, rising terminals manage two main interactional tasks: they pro-videa place for a coparticipant to mark recipiency, and they project more talk by thecurrent speaker. Using a methodology which combines phonetic observation withconversation analysis, we demonstrate participants’ orientation to these functions

Overweight in school-aged children and its relationship with demographic and lifestyle factors: results from the who-collaborative health behaviour in school-aged children (HBSC) study

Objectives: To examine overweight prevalence and its association with demographic and lifestyle factors in 11-15 year olds in the HBSC 2005-2006 survey. Methods: Self-reports of height, weight, eating patterns, physical activity and sedentary behaviours were obtained from nationally representative samples in 41 countries (n=204,534). Results: Overweight prevalence was highest in USA (28.8 %) and lowest in Latvia (7.6 %). In most countries, overweight was more prevalent in boys than girls. Overweight was consistently negatively associated with breakfast consumption and moderate to vigorous physical activity; OR range: 0.48-0.79 and 0.50-0.78, respectively. Conclusion: Overweight prevalence in youth remained high across the countries examined. The primary factors linked to overweight were breakfast consumption and physical activity. These data should contribute to formulating preventive programs and policies. © Birkhäuser Verlag, Basel 2009