Buckling without bending: a new paradigm in morphogenesis

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the oscillations are in-phase. The former cannot be explained by elastic bilayer instability, and contradict the notion that there is a universal mechanism by which brains, intestines, teeth, and other organs develop surface wrinkles and folds. Inspired by the microstructure of the embryonic cerebellum, we develop a new model of 2d morphogenesis in which system-spanning elastic fibers endow the organ with a preferred radius, while a separate fiber network resides in the otherwise fluid-like film at the outer edge of the organ and resists thickness gradients thereof. The tendency of the film to uniformly thicken or thin is described via a "growth potential". Several features of cerebellum, +blebbistatin organoid, and retinal fovea morphogenesis, including out-of-phase behavior and a film thickness amplitude that is comparable to the radius amplitude, are readily explained by our simple analytical model, as may be an observed scale-invariance in the number of folds in the cerebellum. We also study a nonlinear variant of the model, propose further biological and bio-inspired applications, and address how our model is and is not unique to the developing nervous system.Comment: version accepted by Physical Review

Functional consequence of a novel Y129C mutation in a patient with two contradictory melanocortin-2-receptor mutations

L F C and T-T C are supported by M R C Clinical Research Training Fellowships (grant numbers G0600408, G0700581) and L A M by the Wellcome Trust (grant number 076430/Z/05/7)

Where do They Head for University Studies? The University Destinations of Chinese IBDP Graduates: A Study of the International Baccalaureate Diploma Program in China

Paper PresentationConference theme: Educational Reform and Social Change: East-West DialogueOver the last decade, the number of IB programs adopted by schools around the world has dramatically increased by almost 400% (IB, 2009; Lee et al., in-press). In recent years China has also evidenced an impressive gain in the number of schools adopting IB programs in general and the DP in particular. Specifically, as of 2011, there were 50 IB schools authorized for the implementation of the DP in China. Of these, 43 schools have been authorized since 2003 (IB, 2012), illustrating the fast growth of IBDP schools in China in recent years. Despite such fast growth (and by implication, popularity) of the IBDP schools in China, empirical studies exploring the impact of Chinese IBDP students’ learning outcomes in terms of their university matriculation to foreign universities seems to be almost nonexistent. With this in mind, the primary goal of this proposal is to document the patterns of university destination of IBDP graduates in China over time. To this end, our analysis centers on the following overarching question: Where have Chinese students who previously graduated from the 50 IB schools been educated? Alongside the focus of the main question, we seek answers to more specific questions: Are there any trends in their university destinations in terms of geographical region or university prestige (by ranking)? Are there any significant differences in students’ enrolment in foreign universities before or after the 50 IB schools’ adoption of the DP (in the case that the 50 IB schools implemented different international programs other than the DP before they adopted the IB)? Does the adoption of the DP contribute to the growth (rate) of DP graduates enrolled in foreign universities? To investigate these questions, we adopt a theoretical framework from research of international student mobility. Specifically, we focus on internal and external forces (Altbach, Reisberg & Rumbley, 2009; Li & Bray, 2007) that influence IB graduates’ international flow in terms of university destination. We employ a sequential explanatory design (Creswell, Plano, Gutmann, & Hanson, 2003). As part of the mixed-methods research project, we plan to collect longitudinal data on DP graduates’ destinations for university study since the adoption of the DP. A series of quantitative analysis (e.g., descriptive trend analysis, pre/post comparison “before and after” the 50 IB schools’ adoption of the DP, and longitudinal analysis using piecewise modeling) will be employed to determine trends and patterns in terms of university matriculation of the 50 schools over time. As first of its kind, this study will evidence the impact of the DP on student preparation for university studies abroad. In addition, the dataset may be employed for broader purposes (e.g., program development or evaluation) within the IB and the community of schools in China or East Asian countries.published_or_final_versio

The location of an active nucleus and a shadow of a tidal tail in the ULIRG Mrk 273

Analysis of data from the Chandra X-ray Observatory for the double nucleus ULIRG Mrk 273 reveals an absorbed hard X-ray source coincident with the southwest nucleus, implying that this unresolved, near-infrared source is where an active nucleus resides, while the northern nuclear region contains a powerful starburst that dominates the far infrared luminosity. There is evidence of a slight image extension in the 6–7 keV band, where an Fe K line is present, towards the northern nucleus. A large-scale, diffuse emission nebula detected in soft X-rays contains a dark lane that spatially coincides with a high surface-brightness tidal tail extending ~50 arcsec (40 kpc) to the south. The soft X-ray source is likely located behind the tidal tail, which absorbs X-ray photons along the line of sight. The estimated column density of cold gas in the tidal tail responsible for shadowing the soft X-rays is N_H ≥ 6 × 10^(21) cm^(-2), consistent with the tidal tail having an edge-on orientation

Design of 12.5 kA current leads for the Large Hadron Collider using high temperature superconductor material

The Large Hadron Collider will be equipped with about 8000 superconducting magnets. Some 2600 current leads will feed the currents ranging from 25 to 12500 A. CERN aims to reduce the consumption of liquid helium, using high temperature superconductors in these leads. A development of leads for 12.5 kA is being conducted in collaboration with Oxford Instruments. The design options for these leads are described. A test rig and prototype lead have been made according to one of the options. Electrical contact tests are in progress on BSCCO-2212 and YBCO-123 samples. In the first run, the prototype carried 13000 A

Detecting and Characterizing Small Dense Bipartite-like Subgraphs by the Bipartiteness Ratio Measure

We study the problem of finding and characterizing subgraphs with small \textit{bipartiteness ratio}. We give a bicriteria approximation algorithm \verb|SwpDB| such that if there exists a subset $S$ of volume at most $k$ and bipartiteness ratio $\theta$, then for any $0<\epsilon<1/2$, it finds a set $S'$ of volume at most $2k^{1+\epsilon}$ and bipartiteness ratio at most $4\sqrt{\theta/\epsilon}$. By combining a truncation operation, we give a local algorithm \verb|LocDB|, which has asymptotically the same approximation guarantee as the algorithm \verb|SwpDB| on both the volume and bipartiteness ratio of the output set, and runs in time $O(\epsilon^2\theta^{-2}k^{1+\epsilon}\ln^3k)$, independent of the size of the graph. Finally, we give a spectral characterization of the small dense bipartite-like subgraphs by using the $k$th \textit{largest} eigenvalue of the Laplacian of the graph.Comment: 17 pages; ISAAC 201

Reactivity of Gold Hydrides: O2 Insertion into the Au–H Bond

Dioxygen reacts with the gold(I) hydride (IPr)AuH under insertion to give the hydroperoxide, (IPr)AuOOH, a long-postulated reaction in gold catalysis and the first demonstration of O2 activation by Au-H in a well-defined system. Subsequent condensation gave the peroxide (IPr)Au-OO-Au(IPr) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene). The reaction kinetics are reported, as well as the reactivity of Au(I) hydrides with radical scavengers