4,436 research outputs found
Nonrelativistic hydrogen type stability problems on nonparabolic 3-manifolds
We extend classical Euclidean stability theorems corresponding to the
nonrelativistic Hamiltonians of ions with one electron to the setting of non
parabolic Riemannian 3-manifolds.Comment: 20 pages; to appear in Annales Henri Poincar
Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is life threatening and occurs in up to 30% of MRSA bacteremia cases despite appropriate antimicrobial therapy. Isolates of MRSA that cause antibiotic-persistent methicillin-resistant S. aureus bacteremia (APMB) typically have in vitro antibiotic susceptibilities equivalent to those causing antibiotic-resolving methicillin-resistant S. aureus bacteremia (ARMB). Thus, persistence reflects host-pathogen interactions occurring uniquely in context of antibiotic therapy in vivo. However, host factors and mechanisms involved in APMB remain unclear. We compared DNA methylomes in circulating immune cells from patients experiencing APMB vs. ARMB. Overall, methylation signatures diverged in the distinct patient cohorts. Differentially methylated sites intensified proximate to transcription factor binding sites, primarily in enhancer regions. In APMB patients, significant hypomethylation was observed in binding sites for CCAAT enhancer binding protein-β (C/EBPβ) and signal transducer/activator of transcription 1 (STAT1). In contrast, hypomethylation in ARMB patients localized to glucocorticoid receptor and histone acetyltransferase p300 binding sites. These distinct methylation signatures were enriched in neutrophils and achieved a mean area under the curve of 0.85 when used to predict APMB using a classification model. These findings validated by targeted bisulfite sequencing (TBS-seq) differentiate epigenotypes in patients experiencing APMB vs. ARMB and suggest a risk stratification strategy for antibiotic persistence in patients treated for MRSA bacteremia
Photoionization and ion cyclotron resonance studies of the ion chemistry of ethylene oxide
Time-resolved photoionozation mass spectrometry (PIMS), ion cyclotron resonance spectroscopy (ICR), and photoelectron spectroscopy have been employed to study the formation of the ethylene oxide molecular ion and its subsequent ion–molecule reactions which lead to the products C2H5O+ and C3H5O+. Earlier observations that a structurally and energetically modified species (C2H4O+) * is an intermediate in the production of C3H5O+ are confirmed. The PIMS data detail the effects of internal energy on reactivity, with the ratio of C3H5O+ to C2H5O+ increasing by an order of magnitude with a single quantum of vibrational energy. Evidence is presented for the formation of (C2H4O+) * in a collision-induced isomerization which yields a ring-opened structure by C–C bond cleavage. This species contains considerable internal excitation which is relaxed in collisions with ethylene oxide or bath gases such as SF6 prior to reaction. The relaxed ring-opened C2H4O+ ion reacts with neutral ethylene oxide by CH2 + transfer to yield an intermediate product ion C3H6O+ which gives C3H5O+ by loss of H. Isotopic product distributions observed in a mixture of ethylene oxide and ethylene oxide-d4 are consistent with this mechanism. The effects of ion kinetic energy on reactivity are explored using ICR techniques. Increased reactant ion kinetic energy leads to collision-induced dissociation of C2H4O+ rather than isomerization to the open form
Modulation of oestrone sulphate formation and hydrolysis in breast cancer cells by breast cyst fluid from British and Hungarian women
Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB-231 (ER–) breast cancer cells were employed. The formation and hydrolysis of E1S was measured using radiometric techniques. BCF from British and Hungarian women mainly inhibited E1S hydrolysis in MCF-7 cells while stimulating hydrolysis in MDA-MB-231 cells. The extent of inhibition or stimulation of E1S hydrolysis in these cells was related to the Na+/K+ratio of the BCF. There was a significant inverse relationship between the extent to which BCF samples inhibited hydrolysis in MCF-7 cells and stimulated it in MDA-MB-231 cells. BCF stimulated E1S formation in MCF-7 cells while inhibiting formation in MDA-MB-231 cells. No difference in the ability of BCF from British or Hungarian women to inhibit or stimulate E1S hydrolysis was detected in ER+ or ER– breast cancer cells. In contrast, BCF from British women stimulated E1S formation in ER+ cells (median 82%) to a significantly greater extent (P< 0.01) than BCF from Hungarian women (median 33%). The role that E1S has in breast cancer development remains unclear. The greater stimulation of E1S formation by BCF from British women, who have a higher risk of breast cancer than Hungarian women, suggests that it may act as a storage form of oestrogen within cells that can be activated by oestrone sulphatase. © 2000 Cancer Research Campaig
Circuit Quantum Electrodynamics with a Spin Qubit
Circuit quantum electrodynamics allows spatially separated superconducting
qubits to interact via a "quantum bus", enabling two-qubit entanglement and the
implementation of simple quantum algorithms. We combine the circuit quantum
electrodynamics architecture with spin qubits by coupling an InAs nanowire
double quantum dot to a superconducting cavity. We drive single spin rotations
using electric dipole spin resonance and demonstrate that photons trapped in
the cavity are sensitive to single spin dynamics. The hybrid quantum system
allows measurements of the spin lifetime and the observation of coherent spin
rotations. Our results demonstrate that a spin-cavity coupling strength of 1
MHz is feasible.Comment: Related papers at http://pettagroup.princeton.edu
Asymptotic Improvement of Resummation and Perturbative Predictions in Quantum Field Theory
The improvement of resummation algorithms for divergent perturbative
expansions in quantum field theory by asymptotic information about perturbative
coefficients is investigated. Various asymptotically optimized resummation
prescriptions are considered. The improvement of perturbative predictions
beyond the reexpansion of rational approximants is discussed.Comment: 21 pages, LaTeX, 3 tables; title shortened; typographical errors
corrected; minor changes of style; 2 references adde
Differential physiological changes following internet exposure in higher and lower problematic internet users
Problematic internet use (PIU) has been suggested as in need of further research with a view to being included as a disorder in future Diagnostic and Statistical Manual (DSM) of the American Psychiatric Association, but lack of knowledge about the impact of internet cessation on physiological function remains a major gap in knowledge and a barrier to PIU classification. One hundred and forty-four participants were assessed for physiological (blood pressure and heart rate) and psychological (mood and state anxiety) function before and after an internet session. Individuals also completed a psychometric examination relating to their usage of the internet, as well as their levels of depression and trait anxiety. Individuals who identified themselves as having PIU displayed increases in heart rate and systolic blood pressure, as well as reduced mood and increased state of anxiety, following cessation of internet session. There were no such changes in individuals with no self-reported PIU. These changes were independent of levels of depression and trait anxiety. These changes after cessation of internet use are similar to those seen in individuals who have ceased using sedative or opiate drugs, and suggest PIU deserves further investigation and serious consideration as a disorder
Know The Star, Know the Planet. IV. A Stellar Companion to the Host star of the Eccentric Exoplanet HD 8673b
HD 8673 hosts a massive exoplanet in a highly eccentric orbit (e=0.723).
Based on two epochs of speckle interferometry a previous publication identified
a candidate stellar companion. We observed HD 8673 multiple times with the 10 m
Keck II telescope, the 5 m Hale telescope, the 3.63 m AEOS telescope and the
1.5m Palomar telescope in a variety of filters with the aim of confirming and
characterizing the stellar companion. We did not detect the candidate
companion, which we now conclude was a false detection, but we did detect a
fainter companion. We collected astrometry and photometry of the companion on
six epochs in a variety of filters. The measured differential photometry
enabled us to determine that the companion is an early M dwarf with a mass
estimate of 0.33-0.45 M?. The companion has a projected separation of 10 AU,
which is one of the smallest projected separations of an exoplanet host binary
system. Based on the limited astrometry collected, we are able to constrain the
orbit of the stellar companion to a semi-major axis of 35{60 AU, an
eccentricity ? 0.5 and an inclination of 75{85?. The stellar companion has
likely strongly in uenced the orbit of the exoplanet and quite possibly
explains its high eccentricity.Comment: Accepted to the Astronomical Journal, 6 Pages, 5 Figure
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