АНОМАЛЬНОЕ ОТХОЖДЕНИИ КОРОНАРНЫХ АРТЕРИЙ СЕРДЦА ОТ ЛЕГОЧНЫХ АРТЕРИЙ - СИНДРОМ БЛАНДА-УАЙТА-ГАРЛЕНДА

The paper studies the notion of clinical observation of quite rare сongenital malformation of the heart — anomalous origin of the left coronal artery from a pulmonary barrel. In the article we tried to highlight the features of algorithm execution of radiological methods of diagnostics concerning this little-known pathology, in view of its large clinical interest.Представлено несколько клинико-диагностических наблюдений достаточно редкого врожденного порока сердца — аномального отхождения коронарных артерии от легочных артерий. Мы постарались уделить внимание лучевым методам диагностики этой патологии, так как это представляет большой клинический интерес

EFFECTS OF PROLINE-RICH PEPTIDES OF THE INNATE IMMUNE SYSTEM ON DRUG-RESISTANT BACTERIAL STRAINS

Resistance of pathogenic microorganisms to conventional antibiotics is growing rapidly in recent years, accompanying with an increase of mortality caused by hospital-acquired infections. Therefore, a search for novel drugs to combat antibiotic resistant bacteria is one of the priorities in biomedicine. Natural compounds which are contained in host defense effector cells of humans and animals, may serve as prototypes for developing principally new antibiotics. Such compounds include antimicrobial peptides of innate immunity, in particular, a group of proline-rich peptides. The aim of this work was to evaluate antimicrobial activity of proline-rich peptides, belonging to bactenecins family, against several clinical isolates of drug-resistant Gram-negative bacteria. The bactenecins under examination (ChBac3.4, ChBac5, mini-ChBac7.5Nα, miniChBac7.5Nβ) have been previously found in leukocytes of a domestic goat Capra hircus. We have shown that chemically synthesized analogs of these peptides exhibited a pronounced in vitro antimicrobial activity against Escherichia coli and Acinetobacter baumannii (minimum inhibitory concentrations (MIC) as estimated by a broth microdilution assay varied between 1 to 4 µM) and, to a lesser degree, against Pseudomonas aeruginosa and Klebsiella pneumoniae (MIC 2-16 µM). It was revealed that antibacterial activity of these peptides may be increased if applied in combination with some conventional, antibiotics. E.g., synergistic antimicrobial effects against E. coli have been shown for mini-ChBac7.5Nα bactenecin combined with amikacin (minimal fractional inhibitory concentration index (FICI), 0.375), A. baumannii (FICI, 0.5), and K. pneumoniae (FICI, 0.325), and, using ofloxacin, towards K. pneumoniae (FICI 0.5). Lack of hemolytic activity towards human red blood cells is an important benefit of the studied peptides when used at concentrations several times higher than those showing antimicrobial effects. The data obtained presume certain prospects for further investigations of proline-rich peptides, as well as their structural modifications, for the development of new combined drugs based on these compounds, in order to combat antibiotic-resistant microorganisms, e.g., medications for local applications, various components of medical devices, in particular, venous catheters, stents and wound dressings

АНОМАЛЬНОЕ ОТХОЖДЕНИИ КОРОНАРНЫХ АРТЕРИЙ СЕРДЦА ОТ ЛЕГОЧНЫХ АРТЕРИЙ - СИНДРОМ БЛАНДА-УАЙТА-ГАРЛЕНДА

The paper studies the notion of clinical observation of quite rare сongenital malformation of the heart — anomalous origin of the left coronal artery from a pulmonary barrel. In the article we tried to highlight the features of algorithm execution of radiological methods of diagnostics concerning this little-known pathology, in view of its large clinical interest.Представлено несколько клинико-диагностических наблюдений достаточно редкого врожденного порока сердца — аномального отхождения коронарных артерии от легочных артерий. Мы постарались уделить внимание лучевым методам диагностики этой патологии, так как это представляет большой клинический интерес.</p

Commissioning Test of ATLAS End-Cap Toroidal Magnets

The system of superconducting toroids in the ATLAS experiment at CERN consists of three magnets. The Barrel Toroid was assembled and successfully tested in 2006. Next, two End-Cap Toroids have been tested on surface at 77 K and installed in the cavern, 100-m underground. The End Cap Toroids are based on Al stabilized Nb-Ti/Cu Rutherford cables, arranged in double pancake coils and conduction cooled at 4.6 K. The nominal current is 20.5 kA at 4.1 T peak field in the windings and the stored energy is 250 MJ per toroid. Prior to final testing of the entire ATLAS Toroidal system, each End Cap Toroid passed a commissioning test up to 21 kA to guarantee a reliable performance in the final assembly. In this paper the test results are described. It includes the stages of test preparation, isolation vacuum pumping and leak testing, cooling down, step-by-step charging to full current, training quenches and quench recovery. By fast discharges the quench detection and protection system was checked to demonstrate a safe energy distribution within the magnet after a quench or a triggered fast dump

First full-size ATLAS barrel toroid coil successfully tested up to 22 kA at 4 T

The Superconducting Barrel Toroid is providing (together with the two End-Cap Toroids not presented here) the magnetic field for the muon detectors in the ATLAS Experiment at the LHC at CERN. The toroid with outer dimensions of 25 m length and 20 m diameter, is built up from 8 identical racetrack coils. The coils with 120 turns each are wound with an aluminum stabilized NbTi conductor and operate at 20.5 kA at 3.9 T local field in the windings and is conduction cooled at 4.8 K by circulating forced flow helium in cooling tubes attached to the cold mass. The 8 coils of 25 m * 5 m are presently under construction and the first coils have already been fully integrated and tested. Meanwhile the assembly of the toroid 100 m underground in the ATLAS cavern at CERN has started. The 8 coils are individually tested on surface before installation. In this paper the test of the first coil, unique in size and manufacturing technology, is described in detail and the results are compared to the previous experience with the 9 m long B0 model coil