181 research outputs found
Improvement of educational cognitive activity students in the professional educational organization on the basis of visualization technology of educational information
The aim of the study is to consider the problem of improving the quality of education in the professional educational organizations. Methods. The scientific and pedagogical analyses of the concepts forming a terminological field of a problem are used. The system, competence-based and personal approaches are used for development of models of cognitive visualization. Questioning of students was carried out to establish the level of development of their informative activity. Results. The constituent parts of the modern educational process and the need to create specific conditions for its implementation are identified and described. The author gives a generalized characteristic of visualization technology of educational information. The application of cognitive visualization models using information and communication technologies are proved. The results showing the evolution of motivational indicators of studentsβ activity before and after application of LSM and the Β«MetaplanΒ» in the educational process are presented. Scientific novelty. The pedagogical conditions that allow using information and communication technologies as means of the traineesβ educational informative activity improvement in the professional educational organization are defined. Features of the directed application of methods of cognitive visualization of educational information, both for improvement of educational cognitive activity, and for formation of professional competences of students by profession Β«A chef, a confectionerΒ» are noted. Practical importance. Use of methods of cognitive visualization in educational process on the example of studying of Chemistry and Biology in the professional educational organization is considered in details. The teaching package providing application of methods of cognitive visualization of educational information for the purpose of improvement of educational cognitive activity of students in the professional educational organization is designedΒ Π¦Π΅Π»Ρ. Π‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ β ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡΡ
. ΠΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΡΡ Π½Π°ΡΡΠ½ΠΎ-ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ½ΡΡΠΈΠΉ, ΠΎΠ±ΡΠ°Π·ΡΡΡΠΈΡ
ΡΠ΅ΡΠΌΠΈΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΠΎΠ»Π΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. ΠΠ»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΉ, ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠ½ΠΎΡΡΠ½ΠΎ-ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΈ Π»ΠΈΡΠ½ΠΎΡΡΠ½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ. ΠΠ»Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΠ°Π·Π²ΠΈΡΠΎΡΡΠΈ ΠΏΠΎΠ·Π½Π°Π²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΈΡ
Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ΄Π΅Π»Π΅Π½Ρ ΠΈ ΠΎΠΏΠΈΡΠ°Π½Ρ ΡΠΎΡΡΠ°Π²Π½ΡΠ΅ ΡΠ°ΡΡΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΠΉ Π΄Π»Ρ Π΅Π³ΠΎ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΠ°Π½Π° ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Π½Π°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΡΠ΅Π±Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ. ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Ρ ΠΏΡΠΈΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ, Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ Π΄ΠΎ ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Β«Π»ΠΎΠ³ΠΈΠΊΠΎ-ΡΠΌΡΡΠ»ΠΎΠ²ΡΡ
ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉΒ» (ΠΠ‘Π) ΠΈ Β«ΠΌΠ΅ΡΠ°ΠΏΠ»Π°Π½Π°Β» Π² ΡΡΠ΅Π±Π½ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅. ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠ°ΠΊ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅Π±Π½ΠΎ-ΠΏΠΎΠ·Π½Π°Π²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΡΠ°ΡΠΈΡ
ΡΡ. ΠΡΡΠ°ΠΆΠ΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΡΠ΅Π±Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΊΠ°ΠΊ Π΄Π»Ρ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅Π±Π½ΠΎ-ΠΏΠΎΠ·Π½Π°Π²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΡΠ°ΠΊ ΠΈ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ Ρ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ ΠΏΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΈ Β«ΠΠΎΠ²Π°Ρ, ΠΊΠΎΠ½Π΄ΠΈΡΠ΅ΡΒ». ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ. ΠΠ΅ΡΠ°Π»ΡΠ½ΠΎ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π² ΡΡΠ΅Π±Π½ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ΅Ρ
Π½ΠΈΠΊΡΠΌΠ° Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Ρ
ΠΈΠΌΠΈΠΈ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΡΠ΅Π±Π½ΠΎ-ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ (Π£ΠΠ), ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡΠΈΠΉ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΡΠ΅Π±Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π΄Π»Ρ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅Π±Π½ΠΎ-ΠΏΠΎΠ·Π½Π°Π²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡ
Rationalization of mass consuming
Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎ ΡΡΠ°Π»ΠΎ ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ, Π° ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ Π΄Π΅Π»Π΅Π½ΠΈΡ Π½Π° ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΠ»ΠΎΠΈ Π²ΡΡΡΡΠΏΠ°Π΅Ρ ΡΡΠΎΠ²Π΅Π½Ρ ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ, Π³Π»Π°Π²Π½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ.The modern Russian society has become a consumer society, and the main criterion for separating social groups is the level of consumer mainly material
THE CONTENT OF STEROID HORMONES IN PATIENTS WITH CHOLELITHIASIS, DEPENDING ON THE DISEASE
Here, in this work, the peculiarities of secretion of steroid hormones have been researched in patients with gallstone disease depending on the course of the disease. It is suggested, that the lack of use of cholesterol for steroidogenesis leads to its precipitation in the composition of gallstones, increased cortisol is a limiting factor in inflammatory processes in the gall bladder. The increasing of testosterone synthesis may be considered as an antagonistic component of glucocorticoid regulation of lipid and protein metabolism
Magnetization and specific heat of TbFe3(BO3)4: Experiment and crystal field calculations
We have studied the thermodynamic properties of single-crystalline
TbFe3(BO3)4. Magnetization measurements have been carried out as a function of
magnetic field (up to 50 T) and temperature up to 350K with the magnetic field
both parallel and perpendicular to the trigonal c-axis of the crystal. The
specific heat has been measured in the temperature range 2-300K with a magnetic
field up to 9 T applied parallel to the c-axis. The data indicate a structural
phase transition at 192 K and antiferromagnetic spin ordering at 40 K. A
Schottky anomaly is present in the specific heat data around 20 K, arising due
to two low-lying energy levels of the Tb3+ ions being split by f-d coupling.
Below TN magnetic fields parallel to the c-axis drive a spin-flop phase
transition, which is associated with a large magnetization jump. The highly
anisotropic character of the magnetic susceptibility is ascribed mainly to the
Ising-like behavior of the Tb3+ ions in the trigonal crystal field. We describe
our results in the framework of an unified approach which is based on
mean-field approximation and crystal-field calculations.Comment: 10 pages, 10 figures, 20 references, accepted by Phys. Rev.
The changes of the tubular epithelium phenotype in the contralateral kidney nephrons while developing unilateral ureteral obstruction: an experimental study
Introduction. The high prevalence of renal diseases caused by urinary tract obstruction led to the need for experimental research of compensatory and pathological processes with kidney injury. It is also of relevance to study key mechanisms providing a compensatory function of the contralateral kidney for early diagnosis, treatment, and prognosis of obstructive renal diseases.Purpose of the study. To examine epithelial nephron cells phenotype dynamics changes in contralateral kidney using unilateral ureteral obstruction experimental model.Materials and methods. Model of unilateral ureteral obstruction was established using adult rabbits. The studies were carried out on days 7, 14 and 21 of complete obstruction of the left ureter. Immunophenotyping was performed on contralateral kidney tissue samples using epithelial (cytokeratin 7, E-cadherin) and mesenchymal (vimentin, Ξ±-smooth muscle actin) markers.Results. The contralateral kidney under additional load can maintain the morphological and functional characteristics of the nephron for a long time. The first transmogrify signs in the nephron epithelium phenotype were detected by day 21 as the diffuse appearance of mesenchymal marker vimentin with unaltered visualization of epithelial phenotype markers.Conclusion. The results obtained allow us to assume that the compensatory reserve of the contralateral kidney is gradually decreasing when the duration of the obstruction increases. Thus, the likelihood of developing negative disorders increases
ΠΠ½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠ°ΠΊΠ΅ΡΠ° Mathcad
The variant of implementation of elements of research activity in the process of mastering by the first-year students of the technical directions of training in the discipline "Informatics" is considered. The proposed example is based on the application of mathematical packages for analyzing and processing experimental data, obtained in the course of physical experiment.Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ Π²Π°ΡΠΈΠ°Π½Ρ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π² ΠΏΡΠΎΡΠ΅ΡΡ ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΠΊΡΡΡΠ° ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΡΡΠ΅Π±Π½ΠΎΠΉ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Ρ Β«ΠΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΊΠ°Β». ΠΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌΡΠΉ ΠΏΡΠΈΠΌΠ΅Ρ ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°Π΅ΡΡΡ Π½Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΠΊΠ΅ΡΠΎΠ² Π΄Π»Ρ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΡΡ
Π² Ρ
ΠΎΠ΄Π΅ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°
NanΠΎbiocomposite based on dihydroquercetin and arabinogalactan in the form of a gel for external use as a means for the treatment of chronic venous insufficiency in an experiment
Background. Due to the high prevalence of chronic venous insufficiency among the population, with a decrease in the quality of life of patients and their early disability, there is a need to develop modern effective and safe means for the prevention and treatment of this pathology. We have developed the optimal composition and technology of a gel for external use based on a nanobiocomposite of dihydroquercetin and arabinogalactan, which has a venoprotective effect. The article presents data on the results of a preclinical study of the safety and specific activity of the gel.The aim. To study the specific activity (decongestant, antitranssudative action) and safety of a gel for external use based on nanobiocomposite of dihydroquercetin and arabinogalactan used for the treatment of chronic venous insufficiency in the framework of preclinical studies.Materials and methods. The object of the study was a gel for external use based on dihydroquercetin and arabinogalactan nanobiocomposite. The study was conducted on 32 white male rats of the same age, for 15 days. The study of the pharmacological activity of a gel based on a nanobiocomposite of dihydroquercetin and arabinogalactan, was carried out on a model of acute venous stagnation in the tail of a rat (edema of non-inflammatory genesis), the dynamics of tail volume growth in the experimental and control group of animals was evaluated. The irritant effect of the gel on the skin of animals was also determined, the permeability of the capillaries of the skin was determined.Results. When studying the pharmacological activity of the gel on a model of acute venous stagnation in the tail, it was shown that a soft dosage form for external use developed on the basis of nanobiocomposite of dihydroquercetin and arabinogalactan has decongestant and antitranssudative activity. The presence of a locally irritating effect in the gel under study has not been established in the framework of the experiment.Conclusion. In the course of preclinical study of the gel of the nanobiocomposite dihydroquercetin and arabinogalactan on laboratory animals, its antitranssudative activity and safety have been proven
Outpatient Practice of Lipid-Lowering Therapy Prescription (According to the ARGO-3 Study)
Aim. To study the frequency of prescriptions of various types of lipid-lowering therapy and their effectiveness in outpatient clinical practice based on the results of a questionnaire of primary care physicians.Material and methods. The study was performed in 2022 in 75 constituent entities of the Russian Federation with the participation of 1117 doctors working in outpatient clinics. Most of the doctors had work experience of 10-20 years or more. Doctors of polyclinics (therapists and cardiologists, etc.) before the start of the study received instructions, questionnaires for filling out, developed by the National Atherosclerosis Society. The frequency of prescriptions by primary care physicians of various types of lipid-lowering therapy and their effectiveness in terms of the frequency of achieving target levels of low-density lipoprotein cholesterol (LDL-C) was studied based on the results of a questionnaire.Results. Monotherapy with statins was prescribed in 55.2% of cases, free combination of rosuvastatin with ezetimibe β in 17.2%, single pill combination of rosuvastatin with ezetimibe β in 23.2%, combination therapy with PCSK9 inhibitors β in 4.1% of cases. Target levels of LDL-C Λ 1.8 mmol/l and Λ 1.4 mmol/l were achieved with statin monotherapy in 42.6% and 28.2% of cases, respectively, free combination of rosuvastatin with ezetimibe β in 61.7% and 39 .5%, a fixed combination of rosuvastatin with ezetimibe β in 67.8% and 48.5%, combination therapy with PCSK9 inhibitors β in 96.8% and 92.8% of cases.Conclusion. The single pill combination of rosuvastatin with ezetimibe is more effective in achieving target levels of LDL-C compared with statin monotherapy and therapy with free combination of statin with ezetimibe. Despite the fact that the target values of LDL-C when prescribing a combination with PCSK9 inhibitors were achieved in 96.8% and 92.8% of cases, they were used quite rarely at the outpatient stage of treatment in the Russian Federation
Atorvastatin: old friend in the light of novel coronavirus infectionβs pandemia
The COVID-19 (COronaVIrus Disease 2019) pandemic caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirusΒ 2) continues to be a global threat to people and health systems. As of March 21, 2022, there are more than 460 million cases and more than 6 million deaths worldwide, and more than 17 million and 360,000 respectively in the Russian Federation. Due to the rapid spread of the new coronavirus infection, since the beginning of the pandemic, tremendous efforts have been made to create new pharmacological agents to reduce morbidity and mortality, and tactics have been used to repurpose existing medications in treatment regimens for patients with COVID-19, particularly statins. Statins represent one of the most widely used and prescribed classes of drugs in the world. The hypolipidemic properties of statins are actively used to treat hyperlipidemia and primary and secondary prevention of cardiovascular diseases and their complications. Statins have a known safety profile, are inexpensive and accessible. In addition to their hypolipidemic effects, statins have a wide range of pleiotropic anti-inflammatory, antiviral, and antithrombotic effects potentially useful in the treatment of COVID-19. Presumably, the use of statins can reduce SARS-CoV-2-induced organ and tissue damage and improve lung function. The use of statins, particularly atorvastatin, as one of the most effective, widely prescribed and studied drugs in this class, as a safe, affordable and relatively inexpensive therapy may be a promising therapeutic approach in the fight against a new coronavirus infection
The implementation elements of the rating assessment system
The variant of implementation of elements rating system for students of correspondence courses.Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ Π²Π°ΡΠΈΠ°Π½Ρ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΉΡΠΈΠ½Π³ΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Π·Π°ΠΎΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΡ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ
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