An anatomico physiological principle governing the direction of the gastro intestinal mucosal folds during life

ArticleThe original publication is available at http://www.samj.org.zaThe mucosa, being the innermost layer of the gastro intestinal tract, is intimately concerned with digestion and absorption, and, presumably, also with the transport of intestinal contents. In anatomical, physiological and motility studies, possible movements of the mucosa and its folds are neither considered nor investigated. Dogmatic statements about the direction of the folds are often made. Radiologists have long been aware of mucosal movements, but after the fundamental work of Forssell, no further views have been put forward. Radiological procedures have been used to investigate the normal, macroscopic, physiological movements of mucosal folds. A general rule follows. Normally, when the intestine is filled, but inactive, the folds are circular; when the walls contract, the folds change in direction, to become longitudinal. This phenomenon is confirmed by in vivo baboon studies and elucidated by wire spirals. It is seen to be an inherent characteristic of 'peristaltic' and 'segmental' contractions. In this manner longitudinal mucosal furrows are formed simultaneously with the contraction wave of the walls, thus facilitating transit. Were this not so, peristalsis would be an ineffective mechanism, with contraction waves acting against the resistance of circular folds.Publishers’ versio

Retreating rights: Human rights, pre-theoretical praxes and student activism in South African universities

This paper is a recognition-theoretical reading of a research-study on pre-theoretical understandings of human rights amongst university students as ways to logically anchor agential options for student social activism. The study shows that the expected legal and political constructions of human rights are discursively dominant. However, from the overall results of the study, it appears students have more complex pre-theoretical understandings of human rights from which they derive justice-orientations as sources for activism. We conclude this has deliberative implications for human rights praxes

New Protocols and Lower Bound for Quantum Secret Sharing with Graph States

We introduce a new family of quantum secret sharing protocols with limited quantum resources which extends the protocols proposed by Markham and Sanders and by Broadbent, Chouha, and Tapp. Parametrized by a graph G and a subset of its vertices A, the protocol consists in: (i) encoding the quantum secret into the corresponding graph state by acting on the qubits in A; (ii) use a classical encoding to ensure the existence of a threshold. These new protocols realize ((k,n)) quantum secret sharing i.e., any set of at least k players among n can reconstruct the quantum secret, whereas any set of less than k players has no information about the secret. In the particular case where the secret is encoded on all the qubits, we explore the values of k for which there exists a graph such that the corresponding protocol realizes a ((k,n)) secret sharing. We show that for any threshold k> n-n^{0.68} there exists a graph allowing a ((k,n)) protocol. On the other hand, we prove that for any k< 79n/156 there is no graph G allowing a ((k,n)) protocol. As a consequence there exists n_0 such that the protocols introduced by Markham and Sanders admit no threshold k when the secret is encoded on all the qubits and n>n_0

Dimensions Affecting Representation Styles in Ontologies

There are different ways to formalise roughly the same knowledge, which negatively affects ontology reuse and alignment and other tasks such as formalising competency questions automatically. We aim to shed light on, and make more precise, the intuitive notion of such `representation styles' through characterising their inherent features and the dimensions by which a style may differ. This has led to a total of 28 different traits that are partitioned over 10 dimensions. The operationalisability was assessed through an evaluation of 30 ontologies on those dimensions and applicable values. It showed that it is feasible to use the dimensions and values and resulting in three easily recognisable types of ontologies. Most ontologies had clearly one or the other trait, whereas some were inherently mixed due to inclusion of different and conflicting design decisions

Spatio-structural granularity of biological material entities

<p>Abstract</p> <p>Background</p> <p>With the continuously increasing demands on knowledge- and data-management that databases have to meet, ontologies and the theories of granularity they use become more and more important. Unfortunately, currently used theories and schemes of granularity unnecessarily limit the performance of ontologies due to two shortcomings: (i) they do not allow the integration of multiple granularity perspectives into one granularity framework; (ii) they are not applicable to cumulative-constitutively organized material entities, which cover most of the biomedical material entities.</p> <p>Results</p> <p>The above mentioned shortcomings are responsible for the major inconsistencies in currently used spatio-structural granularity schemes. By using the Basic Formal Ontology (BFO) as a top-level ontology and Keet's general theory of granularity, a granularity framework is presented that is applicable to cumulative-constitutively organized material entities. It provides a scheme for granulating complex material entities into their constitutive and regional parts by integrating various compositional and spatial granularity perspectives. Within a scale dependent resolution perspective, it even allows distinguishing different types of representations of the same material entity. Within other scale dependent perspectives, which are based on specific types of measurements (e.g. weight, volume, etc.), the possibility of organizing instances of material entities independent of their parthood relations and only according to increasing measures is provided as well. All granularity perspectives are connected to one another through overcrossing granularity levels, together forming an integrated whole that uses the <it>compositional object perspective </it>as an integrating backbone. This granularity framework allows to consistently assign structural granularity values to all different types of material entities.</p> <p>Conclusions</p> <p>The here presented framework provides a spatio-structural granularity framework for all domain reference ontologies that model cumulative-constitutively organized material entities. With its multi-perspectives approach it allows querying an ontology stored in a database at one's own desired different levels of detail: The contents of a database can be organized according to diverse granularity perspectives, which in their turn provide different <it>views </it>on its content (i.e. data, knowledge), each organized into different levels of detail.</p

A classification of grammar-infused templates for ontology and model verbalisation

Involving domain-experts in the development, maintenance, and use of knowledge organisation systems can be made easier through the introduction of easy-to-use interfaces that are based on natural language. Well resourced languages make use of natural language generation techniques to provide such interfaces. In particular, they often make use of templates combined with computational grammar rules to generate grammatically complex text. However, there is no model of pairing templates and computational grammar rules to ensure suitability for less-resourced languages. These languages require a modular design that ensures grammar detachability so as to allow grammar re-use across domains and applications. In this paper, we present a model and classification scheme for grammar-infused templates suited for less-resourced languages and classify existing systems that make use of them. We have found that of the 15 systems that pair templates and grammar rules, and their 11 distinct template types, 13 have support for detachable grammars

Conceptual Model Interoperability: a Metamodel-driven Approach

Linking, integrating, or converting conceptual data models represented in different modelling languages is a common aspect in the design and maintenance of complex information systems. While such languages seem similar, they are known to be distinct and no unifying framework exists that respects all of their language features in either model transformations or inter-model assertions to relate them. We aim to address this issue using an approach where the rules are enhanced with a logic-based metamodel. We present the main approach and some essential metamodel-driven rules for the static, structural, components of ER, EER, UML v2.4.1, ORM, and ORM2. The transformations for model elements and patterns are used with the metamodel to verify correctness of inter-model assertions across models in different languages

Abstracting modelling languages: A reutilization approach

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-31095-9_9Proceedings of 24th International Conference, CAiSE 2012, Gdansk, Poland, June 25-29, 2012Model-Driven Engineering automates the development of information systems. This approach is based on the use of Domain-Specific Modelling Languages (DSMLs) for the description of the relevant aspects of the systems to be built. The increasing complexity of the target systems has raised the need for abstraction techniques able to produce simpler versions of the models, but retaining certain properties of interest. However, developing such abstractions for each DSML from scratch is a time and resource consuming activity. Our solution to this situation is a number of techniques to build reusable abstractions that are defined once and can be reused over families of modelling languages sharing certain requirements. As a proof of concept, we present a catalogue of reusable abstractions, together with an implementation in the MetaDepth multi-level meta-modelling tool.Work funded by the Spanish Ministry of Economy and Competitivity (TIN2011-24139), and the R&D programme of Madrid Region (S2009/TIC-1650)