Integrated semi-continuous manufacturing of lentiviral vectors

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Intensified virus production in suspension HEK293SF cells using high inoculum fed-batch or low-perfusion rate cultures with continuous harvest

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UHPFRC tensile creep at early age

Ultra high performance fibre reinforced concrete (UHPFRC) early age viscoelastic behaviour under tension was investigated. The tests results showed a high creep potential due to the high volume paste (88%). This result is of major importance because the viscoelastic properties contribute to mitigating the high early age stresses generated under restrained shrinkage. This beneficial effect was reflected by the increased linear-relationship between tensile creep and shrinkage. As expected, UHPFRC tensile creep behaviour was also sensitive to the loading level. Above 35% of the tensile strength at the loading age, the material exhibited viscoplastic behaviour. A Maxwell chain model was applied to predict the early age UHPFRC tensile creep and confirms the induced non-linear respons

Evaluation of UHPFRC activation energy using empirical models

The influence of thermal curing on the evolution of the material properties and the UHPFRC behaviour was investigated. Tests results showed a beneficial effect of a high temperature curing on the early age material properties due to the thermo-activation effect on the hydration process. However, an inverse effect was observed at long-term. In our study, activation energy of UHPFRC was evaluated from experimental data by means of empirical models. The traditional maturity-function based on Arrhenius law, generally used to describe thermally activated physical or chemical processes, was used to predict the evolution of the UHPFRC autogenous shrinkage and to validate the applicability of this concept for such cement-based materials. Results showed that the concept based on Arrhenius law could describe correctly temperature effects on UHPFRC for temperature lower than 30°