2,506 research outputs found
Secondary HIV Infection and Mitigation in Cure-Related HIV Trials During Analytical Treatment Interruptions
To the Editor—We are writing to express concerns regarding facts reported in 2 recent Journal of Infectious Diseases articles pertaining to the ANRSLIGHT study, conducted in 18 clinical sites in France between September 2013 and May 2015. Initially, we were delighted to see the authors implemented several inclusion criteria that we believe were likely to ensure safety of participants during the analytical treatment interruption (ATI) that occurred during the trial, for example a nadir of CD4+ T-cell count of ≥300 cells/mm3 and an initial CD4+ T-cell count of ≥600/mm3. However, other aspects are dismaying, including the detailed identifying information about the index participant and partner. We fear it is possible to identify both persons from the elaborate medical and nonmedical history provided. After contacting the study Principal Investigator, Dr Lelièvre, through a European colleague, it appears there were no consents to disclose this information. Thus, we feel strongly that it was inappropriate to include such comprehensive, potentially identifying details
Effect of Milk on Fibronectin and Collagen Type I Binding to \u3ci\u3eStaphylococcus aureus\u3c/i\u3e and Coagulase-Negative Staphylococci Isolated from Bovine Mastitis
Tryptic soy broth (TSB)-grown cells of Staphylococcus aureus isolated from acute and chronic bovine mastitis bound mainly 125I-fibronectin (125I-Fn), whereas strains of nine species of coagulase-negative staphylococci showed a predominant interaction with 125I-collagen (125I-Cn) type I. A particle agglutination assay (PAA) was used to examine the interaction of coagulase-negative staphylococci with 1251-Fn and 125I-Cn immobilized on latex. All 368 coagulase-negative staphylococci demonstrated high 125I-Cn and moderate to low 125I-Fn interactions in the PAA. Cn-PAA reactivity was high among strains of Staphylococcus xylosus (84.2%), Staphylococcus simulans (77.8%), Staphylococcus epidermidis (76.7%), and Staphylococcus hyicus (74.3%), whereas all six Staphylococcus capitis strains clumped Cn-PAA reagent. Incubating TSB-grown cells in 10% skim milk for 1 h decreased the 125I-Fn- and 125I-Cn-binding affinity in most of the S. aureus and coagulase-negative staphylococci, while growth in 10% skim milk for 18 h resulted in more than 90% decrease or complete loss of interaction with these proteins. Decreased 1251-Fn binding in the presence of milk was correlated with protease production but not with 125I-Cn binding
Effect of Milk on Fibronectin and Collagen Type I Binding to \u3ci\u3eStaphylococcus aureus\u3c/i\u3e and Coagulase-Negative Staphylococci Isolated from Bovine Mastitis
Tryptic soy broth (TSB)-grown cells of Staphylococcus aureus isolated from acute and chronic bovine mastitis bound mainly 125I-fibronectin (125I-Fn), whereas strains of nine species of coagulase-negative staphylococci showed a predominant interaction with 125I-collagen (125I-Cn) type I. A particle agglutination assay (PAA) was used to examine the interaction of coagulase-negative staphylococci with 1251-Fn and 125I-Cn immobilized on latex. All 368 coagulase-negative staphylococci demonstrated high 125I-Cn and moderate to low 125I-Fn interactions in the PAA. Cn-PAA reactivity was high among strains of Staphylococcus xylosus (84.2%), Staphylococcus simulans (77.8%), Staphylococcus epidermidis (76.7%), and Staphylococcus hyicus (74.3%), whereas all six Staphylococcus capitis strains clumped Cn-PAA reagent. Incubating TSB-grown cells in 10% skim milk for 1 h decreased the 125I-Fn- and 125I-Cn-binding affinity in most of the S. aureus and coagulase-negative staphylococci, while growth in 10% skim milk for 18 h resulted in more than 90% decrease or complete loss of interaction with these proteins. Decreased 1251-Fn binding in the presence of milk was correlated with protease production but not with 125I-Cn binding
Velocity-selective direct frequency-comb spectroscopy of atomic vapors
We present an experimental and theoretical investigation of two-photon direct
frequency-comb spectroscopy performed through velocity-selective excitation. In
particular, we explore the effect of repetition rate on the
two-photon transitions
excited in a rubidium atomic vapor cell. The transitions occur via step-wise
excitation through the states by use of the direct
output of an optical frequency comb. Experiments were performed with two
different frequency combs, one with a repetition rate of MHz and
one with a repetition rate of MHz. The experimental spectra are
compared to each other and to a theoretical model.Comment: 10 pages, 7 figure
Magnetic field induced lattice anomaly inside the superconducting state of CeCoIn: evidence of the proposed Fulde-Ferrell-Larkin-Ovchinnikov state
We report high magnetic field linear magnetostriction experiments on
CeCoIn single crystals. Two features are remarkable: (i) a sharp
discontinuity in all the crystallographic axes associated with the upper
superconducting critical field that becomes less pronounced as the
temperature increases; (ii) a distinctive second order-like feature observed
only along the c-axis in the high field (10 T ) low
temperature ( 0.35 K) region. This second order transition is
observed only when the magnetic field lies within 20 of the ab-planes and
there is no signature of it above , which raises questions regarding
its interpretation as a field induced magnetically ordered phase. Good
agreement with previous results suggests that this anomaly is related to the
transition to the Fulde-Ferrel-Larkin-Ovchinnikov superconducting state.Comment: 3 figures, 5 page
An Experimental and Semi-Empirical Method to Determine the Pauli-Limiting Field in Quasi 2D Superconductors as applied to -(BEDT-TTF)Cu(NCS): Strong Evidence of a FFLO State
We present upper critical field data for -(BEDT-TTF)Cu(NCS)
with the magnetic field close to parallel and parallel to the conducting
layers. We show that we can eliminate the effect of vortex dynamics in these
layered materials if the layers are oriented within 0.3 degrees of parallel to
the applied magnetic field. Eliminating vortex effects leaves one remaining
feature in the data that corresponds to the Pauli paramagnetic limit ().
We propose a semi-empirical method to calculate the in quasi 2D
superconductors. This method takes into account the energy gap of each of the
quasi 2D superconductors, which is calculated from specific heat data, and the
influence of many body effects. The calculated Pauli paramagnetic limits are
then compared to critical field data for the title compound and other organic
conductors. Many of the examined quasi 2D superconductors, including the above
organic superconductors and CeCoIn, exhibit upper critical fields that
exceed their calculated suggesting unconventional superconductivity. We
show that the high field low temperature state in
-(BEDT-TTF)Cu(NCS) is consistent with the Fulde Ferrell Larkin
Ovchinnikov state.Comment: 8 pages, 9 figures, 10 years of dat
Molecular epidemiology of human pathogens: how to translate breakthroughs into public health practice, Stockholm, November 2011
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