2,696 research outputs found
Dios como fundamento: la tópica trascendental
El presente artículo trata de pensar el concepto de Dios en su respecto lógico (entendida aquí la lógica como ciencia de la verdad) estudiando el sentido de las subrepciones en el marco de la anfibología de los conceptos de reflexión de la primera Crítica kantiana. La operación de sustitución del lugar de Dios como fundamento de lo real por un Dios postulado permite poner en conexión esta cuestión con el problema más general de los límites del conocimiento.Palabras clave: Dios, tópica trascendental, límite, subrepción, fundamento, esquema, icono, ídolo.Abstract:This paper deals with the concept of God from a logical point of view. The concept of subreption and its scope are studied within the framework of the Amphibology of Reflexive Concepts in first Kant’s Critique. The replacement of God as a foundation of the Real for a postulate-God allows us to connect this matter with the more general question of the limits of Knowledge.Keywords: God, Transcedental Topic, Limit, Subreption, Foundation, Schema, Icon, Idol</p
Enriching footsteps sounds in gait rehabilitation in chronic stroke patients: a pilot study
In the context of neurorehabilitation, sound is being increasingly applied for facilitating sensorimotor learning. In this study, we aimed to test the potential value of auditory stimulation for improving gait in chronic stroke patients by inducing alterations of the frequency spectra of walking sounds via a sound system that selectively amplifies and equalizes the signal in order to produce distorted auditory feedback. Twenty‐two patients with lower extremity paresis were exposed to real‐time alterations of their footstep sounds while walking. Changes in body perception, emotion, and gait were quantified. Our results suggest that by altering footsteps sounds, several gait parameters can be modified in terms of left–right foot asymmetry. We observed that augmenting low‐frequency bands or amplifying the natural walking sounds led to a reduction in the asymmetry index of stance and stride times, whereas it inverted the asymmetry pattern in heel–ground exerted force. By contrast, augmenting high‐frequency bands led to opposite results. These gait changes might be related to updating of internal forward models, signaling the need for adjustment of the motor system to reduce the perceived discrepancies between predicted–actual sensory feedbacks. Our findings may have the potential to enhance gait awareness in stroke patients and other clinical conditions, supporting gait rehabilitation
GPCA vs. PCA in Recognition and 3-D Localization of Ultrasound Reflectors
In this paper, a new method of classification and localization of reflectors, using the time-of-flight (TOF) data obtained from ultrasonic transducers, is presented. The method of classification and localization is based on Generalized Principal Component Analysis (GPCA) applied to the TOF values obtained from a sensor that contains four ultrasound emitters and 16 receivers. Since PCA works with vectorized representations of TOF, it does not take into account the spatial locality of receivers. The GPCA works with two-dimensional representations of TOF, taking into account information on the spatial position of the receivers. This report includes a detailed description of the method of classification and localization and the results of achieved tests with three types of reflectors in 3-D environments: planes, edges, and corners. The results in terms of processing time, classification and localization were very satisfactory for the reflectors located in the range of 50–350 cm
The XMM-Newton/INTEGRAL monitoring campaign of IGR J16318-4848
IGR J16318-4848 is the prototype and one of the more extreme examples of the
new class of highly obscured Galactic X-ray sources discovered by INTEGRAL. A
monitoring campaign on this source has been carried out by XMM-Newton and
INTEGRAL, consisting in three simultaneous observations performed in February,
March and August 2004. The long-term variability of the Compton-thick
absorption and emission line complexes will be used to probe the properties of
the circumstellar matter. A detailed timing and spectral analysis of the three
observations is performed, along with the reanalysis of the XMM-Newton
observation performed in February 2003. The results are compared with
predictions from numerical radiative transfer simulations to derive the
parameters of the circumstellar matter. Despite the large flux dynamic range
observed (almost a factor 3 between observations performed a few months apart),
the source remained bright (suggesting it is a persistent source) and
Compton-thick (NH >1.2x10^24 cm-2). Large Equivalent Width (EW) emission lines
from Fe Kalpha, Fe Kbeta and Ni Kalpha were present in all spectra. The
addition of a Fe Kalpha Compton Shoulder improves the fits, especially in the
2004 observations. Sporadic occurrences of rapid X-ray flux risings were
observed in three of the four observations. The Fe Kalpha light curve followed
the continuum almost instantaneously, suggesting that the emission lines are
produced by illumination of small-scale optically-thick matter around the
high-energy continuum source. Using the iron line EW and Compton Shoulder as
diagnostic of the geometry of the matter, we suggest that the obscuring matter
is in a flattened configuration seen almost edge-on.Comment: accepted by Astronomy and Astrophysic
Energy Consumption Analysis Of Machining Centers Using Bayesian Analysis And Genetic Optimization
Responding to the current urgent need for low carbon emissions and high
efficiency in manufacturing processes, the relationships between three
different machining factors (depth of cut, feed rate, and spindle rate) on
power consumption and surface finish (roughness) were analysed by applying a
Bayesian seemingly unrelated regressions (SUR) model. For the analysis, an
optimization criterion was established and minimized by using an optimization
algorithm that combines evolutionary algorithm methods with a derivative-based
(quasi-Newton) method to find the optimal conditions for energy consumption
that obtains a good surface finish quality. A Bayesian ANOVA was also performed
to identify the most important factors in terms of variance explanation of the
observed outcomes. The data were obtained from a factorial experimental design
performed in two computerized numerical control (CNC) vertical machining
centers (Haas UMC-750 and Leadwell V-40iT). Some results from this study show
that the feed rate is the most influential factor in power consumption, and the
depth of cut is the factor with the stronger influence on roughness values. An
optimal operational point is found for the three factors with a predictive
error of less than 0.01% and 0.03% for the Leadwell V-40iT machine and the Haas
UMC-750 machine, respectively
Acelerated partial breast irradiation (APBI) with high dose rate brachytherapy: Feasibility, clinical results in terms of survival, relapse and toxicity
A simplified courtship conditioning protocol to test learning and memory in Drosophila
In Drosophila, a male that has previously been sexually rejected reduces its courtship behavior when confronted again with an unreceptive female. This reduced courting time reflects a memory formation process. Here, we describe a simplified protocol to perform the courtship conditioning assay for assessing the reduced courting time, using regular lab equipment and handmade tools. Every step of the procedure, from raising flies and training to testing and quantification of this memory-related behavior, can be implemented in any practice laboratory.We would like to thank Javier Gil Castillo for its invaluable help and advices in 3D printing. We also thank the flies from Bloomington Stock Center. We would like to thank BioRender (www.biorender.com) for the open-access platform used to create the graphical abstract.
This work was supported by the Spanish Research Agency (Ministerio de Innovacion y Ciencia [MICINN]) under the grant PGC2018-094630-B-100 to F.A.M., cofinanced by the European Regional Development Fund (ERDF) to F.A.M. F.A.M. is a recipient of a RyC-2014-14961 contract. B.G.-M. is a recipient of a FPI-UAM predoctoral fellowship, grant number SFPI/2020/00878. C.G.B. is a recipient of a FPU predoctoral fellowship, grant number FPU19/04449 (MEFP). S.P.-F. is a recipient of a JAE intro fellowship, grant number JAEINT_21_02520 (CSIC)
Meeting high precision requirements of additively manufactured components through hybrid manufacturing
A hybrid approach combining the laser powder bed fusion (LPBF) process and post-processing operations
through 5-axis milling was employed to manufacture a Ti6Al4V aerospace component. From the design
step, the requirements and needs in all the stages of the Hybrid Additive Manufacturing process were taken
into account. A numerical simulation of distortions promoted by residual stresses during the additive
process was employed to consider material allowance. The status of the as-built and post-processed
component was analysed through scanning and CMM inspection and roughness measurements. The 3D
scanned model of the as-built LPBF-ed component was used to understand the distortion behaviour of the
component and compared to the numerical simulation. Finally, 5-axis milling operations were conducted in
some critical surfaces in order to improve surface quality and dimensional accuracy of the as-built com-
ponent. The inspection of the as-built and post-processed component showed the improvement achieved
through the proposed hybrid approach. The work aims to provide the baselines needed to enable the metal
Hybrid Additive Manufacturing of components with complex geometries where mandatory precision is
required by integrating high accuracy machining operations as post-processing technique
Opportunities for antibiotic optimisation and outcome improvement in patients with negative blood cultures: study protocol for a cluster-randomised crossover trial, the NO-BACT study.
Introduction Patients with negative blood cultures (BCx)
represent 85%–90% of all patients with BCx taken during
hospital admission. This population usually includes a
heterogeneous group of patients admitted with infectious
diseases or febrile syndromes that require a blood culture.
There is very little evidence of the clinical characteristics
and antibiotic treatment given to these patients.
Methods and analysis In a preliminary exploratory
prospective cohort study of patients with BCx taken,
the clinical/therapeutic characteristics and outcomes/
antimicrobial stewardship opportunities of a population of
patients with negative BCx will be analysed. In the second
phase, using a cluster randomised crossover design,
the implementation of an antimicrobial stewardship
intervention targeting patients with negative BCx will be
evaluated in terms of quality of antimicrobial use (duration
and de-escalation), length of hospital stay and mortality.
Ethics and dissemination This study has been and
registered with clinicaltrials.gov. The findings of our study
may support the implementation in clinical practice of an
antimicrobial stewardship intervention to optimise the use
of antibiotics in patients with negative BCx. The results of
this study will be published in peer-reviewed journals and
disseminated at national and international conferences.
Trial registration number NCT03535324.Instituto de Salud Carlos III PI17 / 01809Plataforma Española de Investigación Clínica y Ensayos Clínicos, SCReN (Red Española de Investigación Clínica), financiada por la Subdirección General de Evaluación y Promoción de la Investigación ISCIII: PT17 / 0017/0012. Cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER)
Stimulation of endothelial progenitor cells: a new putative effect of several cardiovascular drugs
The role of vascular endothelium in cardiovascular disorders is well recognized. Mature endothelial cells contribute to the repair of endothelial injury, but they only have a limited capacity to do so. This has led to growing interest and further investigation into circulating endothelial progenitor cells (EPCs) and their role in vascular healing, repair, and postnatal neovascularization. The current perception of vascular health is that of a balance between ongoing injury and resultant vascular repair, mediated at least in part by circulating EPCs. Circulating EPCs play an important role in accelerating endothelialization at areas of vascular damage, and EPC enumeration is a viable strategy for assessing reparative capacity. Recent studies have shown that EPCs are affected both in number and function by several cardiovascular risk factors as well as various cardiovascular disease states, such as hypertension, hypercholesterolemia, and coronary artery disease. The present review summarizes the most relevant studies on the effects of cardiovascular drugs on vascular function and EPCs, focusing on their mechanisms of action
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