137 research outputs found
Selfoscillations of Suspended Carbon Nanotubes with a Deflection Sensitive Resistance under Voltage Bias
We theoretically investigate the electro-mechanics of a Suspended Carbon
Nanotube with a Deflection Sensitive Resistance subjected to a homogeneous
Magnetic Field and a constant Voltage Bias. We show that, (with the exception
of a singular case), for a sufficiently high magnetic field the
time-independent state of charge transport through the nanotube becomes
unstable to selfexcitations of the mechanical vibration accompanied by
oscialltions in the voltage drop and current across the nanotube.Comment: 4 pages, 1 figur
Continuous mode cooling and phonon routers for phononic quantum networks
We study the implementation of quantum state transfer protocols in phonon
networks, where in analogy to optical networks, quantum information is
transmitted through propagating phonons in extended mechanical resonator arrays
or phonon waveguides. We describe how the problem of a non-vanishing thermal
occupation of the phononic quantum channel can be overcome by implementing
optomechanical multi- and continuous mode cooling schemes to create a 'cold'
frequency window for transmitting quantum states. In addition, we discuss the
implementation of phonon circulators and switchable phonon routers, which rely
on strong coherent optomechanical interactions only, and do not require strong
magnetic fields or specific materials. Both techniques can be applied and
adapted to various physical implementations, where phonons coupled to spin or
charge based qubits are used for on-chip networking applications.Comment: 33 pages, 8 figures. Final version, a few minor changes and updated
reference
Exciton-assisted optomechanics with suspended carbon nanotubes
We propose a framework for inducing strong optomechanical effects in a
suspended carbon nanotube based on deformation potential exciton-phonon
coupling. The excitons are confined using an inhomogeneous axial electric field
which generates optically active quantum dots with a level spacing in the
milli-electronvolt range and a characteristic size in the 10-nanometer range. A
transverse field induces a tunable parametric coupling between the quantum dot
and the flexural modes of the nanotube mediated by electron-phonon
interactions. We derive the corresponding excitonic deformation potentials and
show that this interaction enables efficient optical ground-state cooling of
the fundamental mode and could allow us to realise the strong and ultra-strong
coupling regimes of the Jaynes-Cummings and Rabi models.Comment: 25 pages, 2 figure
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy
<p>Abstract</p> <p>Background</p> <p>Overexpression of sphingosine kinase-1 (SPHK1) has been demonstrated to be associated with the development and progression in various types of human cancers. The current study was to characterize the expression of SPHK1 in salivary gland carcinomas (SGC) and to investigate the association between SPHK1 expression and progression of SGC.</p> <p>Methods</p> <p>The expression of SPHK1 was examined in 2 normal salivary gland tissues, 8 SGC tissues of various clinical stages, and 5 pairs of primary SGC and adjacent salivary gland tissues from the same patient, using real-time PCR and western blot analysis. Furthermore, the SPHK1 protein expression was analyzed in 159 clinicopathologically characterized SGC cases by immunohistochemistry. Statistical analyses were performed to determine the prognostic and diagnostic associations.</p> <p>Results</p> <p>SPHK1 expression was found to be markedly upregulated in SGC tissues than that in the normal salivary gland tissues and paired adjacent salivary gland tissues, at both mRNA and protein levels. Statistical analysis revealed a significant correlation of SPHK1 expression with the clinical stage (<it>P </it>= 0.005), T classification (<it>P </it>= 0.017), N classification (<it>P </it>= 0.009), M classification (<it>P </it>= 0.002), and pathological differentiation (<it>P </it>= 0.013). Patients with higher SPHK1 expression had shorter overall survival time, whereas patients with lower SPHK1 expression had better survival. Importantly, patients in the group without adjuvant therapy who exhibited high SPHK1 expression had significantly lower overall survival rates compared with those with low SPHK1 expression. Moreover, multivariate analysis suggested that SPHK1 expression might be an independent prognostic indicator for the survival of SGC patients.</p> <p>Conclusions</p> <p>Our results suggest that SPHK1 expression is associated with SGC progression, and might represent as a novel and valuable predictor for adjuvant therapy to SGC patients.</p
Master Equation for the Motion of a Polarizable Particle in a Multimode Cavity
We derive a master equation for the motion of a polarizable particle weakly
interacting with one or several strongly pumped cavity modes. We focus here on
massive particles with complex internal structure such as large molecules and
clusters, for which we assume a linear scalar polarizability mediating the
particle-light interaction. The predicted friction and diffusion coefficients
are in good agreement with former semiclassical calculations for atoms and
small molecules in weakly pumped cavities, while the current rigorous quantum
treatment and numerical assessment sheds a light on the feasibility of
experiments that aim at optically manipulating beams of massive molecules with
multimode cavities.Comment: 30 pages, 5 figure
Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory
The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD. Here we behaviorally phenotyped a novel Val66Met rat model with an equivalent valine to methionine substitution in the rat Bdnf gene (Val68Met). In a three-day fear conditioning protocol of fear learning and extinction, adult rats with the Met/Met genotype demonstrated impaired fear memory compared to Val/Met rats and Val/Val controls, with no genotype differences in fear learning or extinction. This deficit in fear memory occurred irrespective of the sex of the animals and was not seen in adolescence (4 weeks of age). There were no changes in open-field locomotor activity or anxiety measured in the elevated plus maze (EPM) nor in other types of memory measured using the novel-object recognition test or Y-maze. BDNF exon VI expression in the dorsal hippocampus was higher and BDNF protein level in the ventral hippocampus was lower in female Val/Met rats than female Val/Val rats, with no other genotype differences, including in total BDNF, BDNF long, or BDNF IV mRNA. These data suggest a specific role for the BDNF Met/Met genotype in fear memory in rats. Further studies are required to investigate gene–environment interactions in this novel animal model
Patient survival after D 1 and D 2 resections for gastric cancer: long-term results of the MRC randomized surgical trial
Controversy still exists on the optimal surgical resection for potentially curable gastric cancer. Much better long-term survival has been reported in retrospective/non-randomized studies with D 2 resections that involve a radical extended regional lymphadenectomy than with the standard D 1 resections. In this paper we report the long-term survival of patients entered into a randomized study, with follow-up to death or 3 years in 96% of patients and a median follow-up of 6.5 years. In this prospective trial D 1 resection (removal of regional perigastric nodes) was compared with D 2 resection (extended lymphadenectomy to include level 1 and 2 regional nodes). Central randomization followed a staging laparotomy
Synthesis of phosphonate-functionalized polystyrene and poly(methyl methacrylate) particles and their kinetic behavior in miniemulsion polymerization
Phosphonate-functionalized polymer nanoparticles were synthesized by free-radical copolymerization of vinylphosphonic acid (VPA) with styrene or methyl methacrylate (MMA) using the miniemulsion technique. The influence of different parameters such as monomer and surfactant type, amount of vinylphosphonic acid on the average particle size, and size distribution was studied using dynamic light scattering and transmission electron microscopy. Depending on the amount and type of the surfactant used (ionic or non-ionic), phosphonate-functionalized particles in a size range from 102 to 312 nm can be obtained. The density of the phosphonate groups on the particle surface was higher in the case of using MMA as a basis monomer than polystyrene. The kinetic behavior of VPA copolymerization with styrene or MMA using a hydrophobic initiator was investigated by reaction calorimetry. Different kinetic curves were observed for miniemulsion (co)polymerization of styrene- and MMA-based nanoparticles indicating different nucleation mechanisms
Electrical Conductivity of Electrospun Polyaniline and Polyaniline-Blend Fibers and Mats
Submicrometer fibers of polyaniline (PAni) doped with (+)-camphor-10-sulfonic acid (HCSA) and blended with poly(methyl methacrylate) (PMMA) or poly(ethylene oxide) were electrospun over a range of compositions. Continuous, pure PAni fibers doped with HCSA were also produced by coaxial electrospinning and subsequent removal of the PMMA shell polymer. The electrical conductivities of both the fibers and the mats were characterized. The electrical conductivities of the fibers were found to increase exponentially with the weight percent of doped PAni in the fibers, with values as high as 50 ± 30 S/cm for as-electrospun fibers of 100% doped PAni and as high as 130 ± 40 S/cm upon further solid state drawing. These high electrical conductivities are attributed to the enhanced molecular orientation arising from extensional deformation in the electrospinning process and afterward during solid state drawing. A model is proposed that permits the calculation of mat conductivity as a function of fiber conductivity, mat porosity, and fiber orientation distribution; the results agree quantitatively with the independently measured mat conductivities.United States. Army Research Office (Institute for Soldier Nanotechnologies, Contract ARO W911NF-07-D- 0004
- …