Rational Design of Polymers for Selective CO2 Reduction Catalysis.

A series of copolymers comprising a terpyridine ligand and various functional groups were synthesized toward integrating a Co-based molecular CO2 reduction catalyst. Using porous metal oxide electrodes designed to host macromolecules, the Co-coordinated polymers were readily immobilized via phosphonate anchoring groups. Within the polymeric matrix, the outer coordination sphere of the Co terpyridine catalyst was engineered using hydrophobic functional moieties to improve CO2 reduction selectivity in the presence of water. Electrochemical and photoelectrochemical CO2 reduction were demonstrated with the polymer-immobilized hybrid cathodes, with a CO:H2 product ratio of up to 6:1 compared to 2:1 for a corresponding "monomeric" Co terpyridine catalyst. This versatile platform of polymer design demonstrates promise in controlling the outer-sphere environment of synthetic molecular catalysts, analogous to CO2 reductases.the Woolf Fisher Trust in New Zealand, the Winston Churchill Foundation of the United States, the Christian Doppler Research Association (Austrian Federal Ministry for Digital and Economic Affairs and the National Foundation for Research, Technology and Development), the OMV Grou

Geographic information retrieval in a mobile environment: evaluating the needs of mobile individuals

This paper describes research that aims to define the information needs of mobile individuals, to implement a mobile information system that can satisfy those needs, and finally to evaluate the performance of that system with end-users. First a review of the emerging discipline of geographic information retrieval (GIR) is presented as background to the more specific issue of mobile information retrieval. Following this, a user needs study is described evaluating the requirements of potential users of a mobile information system; the study finds that there is a strong geographic component to users' information needs. Next, four geographic post-query filters are described which attempt to represent the region of space associated with an individual's query made at some specific spatial location. These filters are spatial proximity (distance in space), temporal proximity (travel time), speed-heading prediction surfaces (likelihood of visiting locations) and visibility (locations that can be seen). Two of these filters — spatial proximity and speed-heading prediction surfaces — are implemented in a mobile information system and subsequently evaluated with users in an outdoor setting. The results of evaluation suggest that retrieved information to which post-query geographic filters have been applied is considered more relevant than unfiltered information, and that users find information sorted by spatial proximity to be more relevant than that sorted by a prediction surface of likely future locations. The paper closes with a discussion of the wider implications of these results for developers of mobile information systems and location-based services

Duloxetine compared with fluoxetine and venlafaxine: use of meta-regression analysis for indirect comparisons

BACKGROUND: Data comparing duloxetine with existing antidepressant treatments is limited. A comparison of duloxetine with fluoxetine has been performed but no comparison with venlafaxine, the other antidepressant in the same therapeutic class with a significant market share, has been undertaken. In the absence of relevant data to assess the place that duloxetine should occupy in the therapeutic arsenal, indirect comparisons are the most rigorous way to go. We conducted a systematic review of the efficacy of duloxetine, fluoxetine and venlafaxine versus placebo in the treatment of Major Depressive Disorder (MDD), and performed indirect comparisons through meta-regressions. METHODS: The bibliography of the Agency for Health Care Policy and Research and the CENTRAL, Medline, and Embase databases were interrogated using advanced search strategies based on a combination of text and index terms. The search focused on randomized placebo-controlled clinical trials involving adult patients treated for acute phase Major Depressive Disorder. All outcomes were derived to take account for varying placebo responses throughout studies. Primary outcome was treatment efficacy as measured by Hedge's g effect size. Secondary outcomes were response and dropout rates as measured by log odds ratios. Meta-regressions were run to indirectly compare the drugs. Sensitivity analysis, assessing the influence of individual studies over the results, and the influence of patients' characteristics were run. RESULTS: 22 studies involving fluoxetine, 9 involving duloxetine and 8 involving venlafaxine were selected. Using indirect comparison methodology, estimated effect sizes for efficacy compared with duloxetine were 0.11 [-0.14;0.36] for fluoxetine and 0.22 [0.06;0.38] for venlafaxine. Response log odds ratios were -0.21 [-0.44;0.03], 0.70 [0.26;1.14]. Dropout log odds ratios were -0.02 [-0.33;0.29], 0.21 [-0.13;0.55]. Sensitivity analyses showed that results were consistent. CONCLUSION: Fluoxetine was not statistically different in either tolerability or efficacy when compared with duloxetine. Venlafaxine was significantly superior to duloxetine in all analyses except dropout rate. In the absence of relevant data from head-to-head comparison trials, results suggest that venlafaxine is superior compared with duloxetine and that duloxetine does not differentiate from fluoxetine

Geographical perspectives on location for location based services

In this position paper the question of how location is employed in location based services (LBS) is considered. The importance of the notion of location is highlighted as a means of blurring the boundary between forms of experiences that are direct, and sensed in the environment, and those that are indirect, and learned from information. It is suggested that current methods for modeling location are limited by their lack of strong theoretical underpinning. To help bridge this gap the notions of Space, Place, and Region, from geographical theory, are proposed and implications of these for considering location in LBS outlined

hierarchical

Techniques for on the-fly generalisation of thematic point data usin

Analysing and aggregating visitor tracks in a protected area

The advent of location-based technologies deployed in protected areas provides both visitors and managers of such areas with new opportunities. In this paper we investigate the potential for mining individual tracks of visitors’ geospatial lifelines to both extract information describing aggregated patterns of group behaviour and characterise individual actions. Methods to spatio-temporally cluster individual behaviour and identify potential locations for specific actions (e.g. do visitors stop here to look at wildlife), whilst handling uncertainty in location, are described and applied to test the hypotheses that firstly, visitor behaviour is altered by the provision of information, and secondly whether the mode of information provision (e.g. in the form of a paper map or though an location-based service) influences visitor behaviour. The results of experiments with 140 visitors to a nature trail on the island of Texel in the Netherlands show statistically significant differences in time spent at locations where information was “pushed” to the visitors

Road network selection using an extended stroke-mesh combination algorithm

The road network is an essential feature class in topographic maps and databases. Road network selection for smaller scales forms a prerequisite for all other generalization operators and is thus a fundamental operation in the overall process of topographic map and database production. The objective of this paper was to develop an algorithm for automated road network selection from a large-scale (1:10,000) to a medium-scale database (1:50,000). The project was pursued in collaboration with swisstopo, the national mapping agency of Switzerland. Three algorithms (a stroke-based, a mesh-based, and a combined stroke-mesh algorithm) were implemented from the literature and analyzed using swisstopo’s large-scale TLM3D spatial database, with requirements set forth by expert cartographers. Initial experiments showed that the combination algorithm performed best, yet still it could not meet all requirements. Therefore, extensions to the basic stroke-mesh algorithm were developed, significantly improving the selection result with real-world, large test databases. Three extensions introduce modifications to the stroke-mesh combination algorithm. Furthermore, two extensions include external feature classes, ensuring accessibility of points of interest and appropriate network density representation in settlement areas, respectively. The results were evaluated by expert cartographers, who concluded that the proposed approach is ready to be deployed in production at swisstopo

Web service approaches for providing enriched data structures to generalisation operators

Web service technologies can be used to establish an interoperable framework between different generalisation systems. In a previous article three categories of generalisation web services were identified, including support services, operator services and processing services. This paper focuses on the category of support services. In a service-based generalisation system, the purpose of support services is to assist the generalisation process by providing auxiliary measures, procedures and data structures that allow the representation of structural cartographic knowledge. The structural knowledge of the spatial and semantic context and the modelling of structural and spatial relationships is critical for the understanding of the role of cartographic features and thus for automated generalisation. Support services should extract and model this knowledge from the raw data and make it available to other generalisation operators. On the one hand the structural knowledge can be expressed by enriching map features with additional geometries or attributes. On the other hand, there exist various hierarchical and nonhierarchical relationships between map features, many of which can be represented by graph data structures. After a brief introduction to the interoperable web service framework, this paper proposes a taxonomy of generalisation support services and discusses its elements. It is then shown how the complex output of such services can be represented for use with web services and stored in a reusable fashion. Finally, the utilisation of support services is illustrated on four implementation examples of support services that also highlight the interactions with the generalisation operators that use these auxiliary services