Force on a sphere via the generalized reciprocal theorem

An approach based on the generalized reciprocal theorem is presented to derive the well-known result for the drag force exerted on a rigid sphere translating in a viscous fluid in an arbitrary manner. The use of generalized reciprocal theorem allows one to bypass the calculation of stress distribution over the particle surface in order to compute the force

Hydrodynamic stress on fractal aggregates of spheres

We calculate the average hydrodynamic stress on fractal aggregates of spheres using Stokesian dynamics. We find that for fractal aggregates of force-free particles, the stress does not grow as the cube of the radius of gyration, but rather as the number of particles in the aggregate. This behavior is only found for random aggregates of force-free particles held together by hydrodynamic lubrication forces. The stress on aggregates of particles rigidly connected by interparticle forces grows as the radius of gyration cubed. We explain this behavior by examining the transmission of the tension along connecting lines in an aggregate and use the concept of a persistance length in order to characterize this stress transmission within an aggregate

Searching Gravitational Waves from Pulsars, Using Laser Beam Interferometers

We use recent population synthesis results to investigate the distribution of pulsars in the frequency space, having a gravitational strain high enough to be detected by the future generations of laser beam interferometers. We find that until detectors become able to recover the entire population, the frequency distribution of the 'detectable' population will be very dependent on the detector noise curve. Assuming a mean equatorial deformation $\epsilon =10^{-6}$, the optimal frequency is around 450 Hz for interferometers of the first generation (LIGO or VIRGO) and shifts toward 85 Hz for advanced detectors. An interesting result for future detection stategies is the significant narrowing of the distribution when improving the sensitivity: with an advanced detector, it is possible to have 90% of detection probability while exploring less than 20% of the parameter space (7.5% in the case of $\epsilon =10^{-5}$). In addition, we show that in most cases the spindown of 'detectable' pulsars represents a period shift of less than a tens of nanoseconds after one year of observation, making them easier to follow in the frequency space.Comment: 5 pages, 3 figures accepted for publication in Astronomy & Astrophysic

Stability of degenerate Cauchy horizons in black hole spacetimes

In the multihorizon black hole spacetimes, it is possible that there are degenerate Cauchy horizons with vanishing surface gravities. We investigate the stability of the degenerate Cauchy horizon in black hole spacetimes. Despite the asymptotic behavior of spacetimes (flat, anti-de Sitter, or de Sitter), we find that the Cauchy horizon is stable against the classical perturbations, but unstable quantum mechanically.Comment: Revtex, 4 pages, no figures, references adde

Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission

Efficient HTLV-1 viral transmission occurs through cell-to-cell contacts. The Tax viral transcriptional activator protein facilitates this process. Using a comparative transcriptomic analysis, we recently identified a series of genes up-regulated in HTLV-1 Tax expressing T-lymphocytes. We focused our attention towards genes that are important for cytoskeleton dynamic and thus may possibly modulate cell-to-cell contacts. We first demonstrate that Gem, a member of the small GTP-binding proteins within the Ras superfamily, is expressed both at the RNA and protein levels in Tax-expressing cells and in HTLV-1-infected cell lines. Using a series of ChIP assays, we show that Tax recruits CREB and CREB Binding Protein (CBP) onto a c-AMP Responsive Element (CRE) present in the gem promoter. This CRE sequence is required to drive Tax-activated gem transcription. Since Gem is involved in cytoskeleton remodeling, we investigated its role in infected cells motility. We show that Gem co-localizes with F-actin and is involved both in T-cell spontaneous cell migration as well as chemotaxis in the presence of SDF-1/CXCL12. Importantly, gem knock-down in HTLV-1-infected cells decreases cell migration and conjugate formation. Finally, we demonstrate that Gem plays an important role in cell-to-cell viral transmission