Correlated adatom trimer on metal surface: A continuous time quantum Monte Carlo study

The problem of three interacting Kondo impurities is solved within a numerically exact continuous time quantum Monte Carlo scheme. A suppression of the Kondo resonance by interatomic exchange interactions for different cluster geometries is investigated. It is shown that a drastic difference between the Heisenberg and Ising cases appears for antiferromagnetically coupled adatoms. The effects of magnetic frustrations in the adatom trimer are investigated, and possible connections with available experimental data are discussed.Comment: 4 pages, 4 figure

Continuous Time Quantum Monte Carlo method for fermions

We present numerically exact continuous-time Quantum Monte Carlo algorithm for fermions with a general non-local in space-time interaction. The new determinantal grand-canonical scheme is based on a stochastic series expansion for the partition function in the interaction representation. The method is particularly applicable for multi-band time-dependent correlations since it does not invoke the Hubbard-Stratonovich transformation. The test calculations for exactly solvable models as well results for the Green function and for the time-dependent susceptibility of the multi-band super-symmetric model with a spin-flip interaction are discussed.Comment: 10 pages, 7 Figure

SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS

Immunization with xenogeneous tissue antigens is able to interrupt innate immune tolerance interfering immune response to autological analogues. The main part of the differentiation antigens is known to be normally expressed on the surface of numerous organs cells including testis. Thus, anticancer vaccine based on sheep testis spermatogenic epithelium lysed cells reveals notable protective effect in experiment. In this work we decided to investigate immunological aspects of the vaccination resulting in tumor mice lifetime increase. Following, testicular antigen vaccination of the tumor mice is established in addition to the lifetime increase to cause substantial helper and regulatory cells subpopulation increase to stimulate neutrophil release and to intensify tumor neutrophil infiltrate

PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION

Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly increased in MS patients as compared with levels in healthy individuals. T-cells vaccination had no effect on the T-cells memory subpopulation composition. However, vaccine-treated RS patients had significant (by 2 fold) reduction of relative quantity of CD4+IFNγ+IL-4— and CD8+IFNγ+IL-4— memory T-cells, as well as suppression by 6 fold of CD4+ memory cells number, which produce both kinds of cytokines

New materials based on polylactide modified with silver and carbon ions

An integrated study of poly-L-lactide (PL) synthesis and the physicochemical properties of film surfaces, both modified by silver and carbon ion implantation and also unmodified PL surfaces, has been carried out. Surface modification was done using aMevva-5.Ru metal ion source with ion implantation doses of 1·1014, 1·1015 and 1·1016 ion/cm2. Material characterization was done using NMR, IRS, XPS and AFM. The molecular weight (MW), micro-hardness, surface resistivity, and limiting wetting angle of both un-implanted and implanted samples were measured. The results reveal that degradation of PL macromolecules occurs during ion implantation, followed by CO or CO2 removal and MW decrease. With increasing implantation dose, the glycerol wettability of the PL surface increases but the water affinity decreases (hydrophobic behavior). After silver and carbon ion implantation into the PL samples, the surface resistivity is reduced by several orders of magnitude and a tendency to micro-hardness reductionis induced

Influence of soluble factors from the M2 phenotype macrophages on hematopoiesis in depression-like state

Chronic psychosocial stress provokes anxious behavior and depressive disorders. The longitudinal stress-induced neuroendocrine signals may alter functioning of immune (central and peripheral) organs. Increased myelopoiesis is observed in bone marrow, being detrimental to lympho- and erythropoiesis, with increased emigration of monocytic bone marrow cells to the periphery and their acquisition of “inflammatory” phenotype. The subsequent migration of such monocytes to the brain with differentiation into the M1 type macrophages which form inflammatory signals, and their effect upon endothelial cells and microglia leads to increased production of cytokines, chemokines, and adhesion molecules, thus accelerating accumulation of bone marrow-derived monocytes migrating to the brain. The signals from bone marrow monocytes and activated microglia promote neuroinflammatory condition which leads to behavioral changes. Current data on the presence of non-resident bone marrow macrophages in the brain of depressed patients require studies of hematopoiesis in depression-like states. Pronounced plasticity is a characteristic feature of macrophages, i.e., their ability to acquire M1 or M2 phenotype depending on the microenvironment signals. M1 exhibit high pro-inflammatory activity and have neurodestructive properties, whereas M2 cells are characterized by low pro-inflammatory activity and pronounced regenerative potential, due to the production of multiple soluble mediators and cytokines, including neurotrophic and immunoregulatory factors, anti-inflammatory substances that provide neuroprotection, stimulate neurogenesis, synaptogenesis, growth and myelinization of axons, thus theoretically substantiating an opportunity of using the potential of M2 macrophages in the treatment of depression. In this work, we studied the effect of soluble factors of human macrophages, polarized into cells with M2 phenotype under the conditions of serum deprivation, upon bone marrow hematopoiesis and peripheral blood cells in a model of stress-induced depression. We have shown enhanced differentiation of hematopoietic stem cells into the granulocyte-macrophage (CFU-GM) lineage, along with increased monocyte population in peripheral blood in the depressive-like murine model. Development of a depressive-like state in the animals was associated with reduced amounts of both erythroid precursors in bone marrow and erythrocytes/hemoglobin in peripheral blood. Intranasal administration of soluble M2 macrophage factors (M2-SFs) for 7 days was accompanied by a corrective effect on the above parameters, being significant for peripheral blood monocytes. The data obtained suggest effectiveness of the M2-SFS anti-inflammatory effects in correcting changes in hematopoiesis caused by social stress in depressive-like animals

Народосбережение как фактор устойчивого социально-экономического развития регионов России (на примере Центрального федерального округа)

Purpose of the study. To establish the specifics of the situation in the field of saving people in the regions of the Central Federal District, to identify the compliance of the state socio-economic policy with the real state of saving people in the regions of the Russian Federation.Materials and methods. In the process of preparing the article, the authors used the materials of the Federal State Statistics Service, the Territorial State Statistics Service for the Orel region, the works of individual scientists and public organizations on the problems of saving people. In the course of the work, statistical research methods were used: tabular and graphical methods, analysis of dynamics’ series indexes, the grouping method.Results. The dynamics of the population in 1990-2021 was studied in the context of the federal districts of the country, including the regions of the Central Federal District, depending on individual factors (natural, mechanical movement). The study of the population in the regions of the Central Federal District showed that for the period 1990-2021, a decrease in the population was found in all regions of the Central Federal District (except Belgorodskaya, Moscow regions and Moscow). The rural population is decreasing at the fastest pace: mortality rates significantly exceed fertility rates in rural areas, the share of the working-age population is decreasing, and the share of the population older than working age is increasing.Conclusion. The problem of saving people is urgent and requires the development of an effective system for managing the quality of life of the population and regulating demographic processes in the regions of the Central Federal District: Vladimirskaya, Tverskaya, Orlovskaya, Smolenskaya, Tulskaya, Ivanovskaya; in which the decrease in population is associated with natural factors: the mortality rate significantly exceeds the birth rate. It is advisable to form regional programs to improve the organization of healthcare in the following areas: Vladimirskaya, Kalugskaya, Ivanovskaya, Orlovskaya, Tverskaya, Yaroslavskaya. To manage migration processes, reduce the labor shortage in accordance with the needs of the region’s economy, create jobs and conditions for the development of small and medium-sized businesses, improve the quality of life of the population, develop appropriate programs in the following areas: Vladimirskaya, Orovskayal, Smolenskaya, Tambovskaya, Tverskaya.Цель исследования. Установление специфики ситуации в сфере народосбережения в регионах Центрального федерального округа, идентифицировать соответствие государственной социально экономической политики реальному состоянию народосбережения в регионах Российской Федерации.Материалы и методы. В процессе подготовки статьи авторами использованы материалы Федеральной службы государственной статистики, Территориальной службы государственной статистики по Орловской области, труды отдельных ученых и общественных организаций по проблемам народосбережения. В ходе работы были использованы статистические методы исследования: табличный и графический методы, анализ показателей рядов динамики, метод группировок.Результаты. Была исследована динамика численности населения в 1990–2021 гг. в разрез федеральных округов страны, в том числе по регионам Центрального федерального округа, в зависимости от отдельных факторов (естественного, механического движения).Исследование численности населения в областях Центрального федерального округа показало, что за период 1990–2021 гг. сокращение численности населения установлено во всех субъектах ЦФО (кроме Белгородской, Московской областях и г. Москва). Наиболее быстрыми темпами уменьшается сельское население: коэффициенты смертности значительно превышают коэффициенты рождаемости в сельской местности, сокращается доля трудоспособного населения, увеличивается доля населения старше трудоспособного возраста.Заключение. Проблема народосбережения является актуальной и требует разработки эффективной системы управления качеством жизни населения и регулирования демографических процессов в областях Центрального федерального округа: Владимирской, Тверской, Орловской, Смоленской, Тульской, Ивановской; в которых уменьшение численности населения связано с естественными факторами: уровень смертности значительно превышает уровень рождаемости. Целесообразно сформировать региональные программы по совершенствованию организации здравоохранения в областях: Владимирской, Калужской, Ивановской, Орловской, Тверской, Ярославской. Для управления миграционными процессами, снижения дефицита рабочей силы в соответствии с потребностями экономики региона, создание рабочих мест и условий развития малого и среднего бизнеса, повышение качества жизни населения разработать соответствующие программы в областях: Владимирской, Орловской, Смоленской, Тамбовской, Тверской

Self-Control of Traffic Lights and Vehicle Flows in Urban Road Networks

Based on fluid-dynamic and many-particle (car-following) simulations of traffic flows in (urban) networks, we study the problem of coordinating incompatible traffic flows at intersections. Inspired by the observation of self-organized oscillations of pedestrian flows at bottlenecks [D. Helbing and P. Moln\'ar, Phys. Eev. E 51 (1995) 4282--4286], we propose a self-organization approach to traffic light control. The problem can be treated as multi-agent problem with interactions between vehicles and traffic lights. Specifically, our approach assumes a priority-based control of traffic lights by the vehicle flows themselves, taking into account short-sighted anticipation of vehicle flows and platoons. The considered local interactions lead to emergent coordination patterns such as ``green waves'' and achieve an efficient, decentralized traffic light control. While the proposed self-control adapts flexibly to local flow conditions and often leads to non-cyclical switching patterns with changing service sequences of different traffic flows, an almost periodic service may evolve under certain conditions and suggests the existence of a spontaneous synchronization of traffic lights despite the varying delays due to variable vehicle queues and travel times. The self-organized traffic light control is based on an optimization and a stabilization rule, each of which performs poorly at high utilizations of the road network, while their proper combination reaches a superior performance. The result is a considerable reduction not only in the average travel times, but also of their variation. Similar control approaches could be applied to the coordination of logistic and production processes

Дозы облучения персонала и населения при нормальной эксплуатации пунктов захоронения радиоактивных отходов

This paper focuses on occupational and public exposure during operation of disposal facilities receiving liquid and solid radioactive waste of various classes and provides a comparative analysis of the relevant doses: actual and calculated at the design stage. Occupational and public exposure study presented in this paper covers normal operations of a radioactive waste disposal facility receiving waste. Results: Analysis of individual and collective occupational doses was performed based on data collected during operation of near-surface disposal facilities for short-lived intermediate-, lowand very low-level waste in France, as well as nearsurface disposal facilities for long-lived waste in Russia. Further analysis of occupational and public doses calculated at the design stage was completed covering a near-surface disposal facility in Belgium and deep disposal facilities in the United Kingdom and the Nizhne-Kansk rock massive (Russia). The results show that engineering and technical solutions enable almost complete elimination of internal occupational exposure, whereas external exposure doses would fall within the range of values typical for a basic nuclear facility. Conclusion: radioactive waste disposal facilities being developed, constructed and operated meet the safety requirements effective in the Russian Federation and consistent with relevant international recommendations. It has been found that individual occupational exposure doses commensurate with those received by personnel of similar facilities abroad. Furthermore, according to the forecasts, mean individual doses for personnel during radioactive waste disposal would be an order of magnitude lower than the dose limit of 20 mSv/year. As for the public exposure, during normal operation, potential impact is virtually impossible by delaminating boundaries of a nuclear facility sanitary protection zone inside which the disposal facility is located and can be solely attributed to the use of public roads during radioactive waste transportation to the disposal facility site. Цель работы – сравнительный анализ фактических и оцениваемых на этапе проектирования доз облучения персонала и населения при захоронении жидких радиоактивных отходов и твердых радиоактивных отходов различных классов. В рамках настоящей статьи рассматривается вариант облучения персонала и населения при нормальной эксплуатации пункта захоронения радиоактивных отходов в режиме размещения отходов. Результаты: выполнен анализ индивидуальных и коллективных доз облучения персонала при приповерхностном захоронении короткоживущих среднеактивных, низкоактивных и очень низкоактивных радиоактивных отходов во Франции, а также при приповерхностном захоронении долгоживущих радиоактивных отходов в России. Проведен анализ проектных оценок доз облучения персонала и населения для объекта приповерхностной изоляции радиоактивных отходов, планируемого к сооружению в Бельгии, а также проектируемых объектов глубинного захоронения в Великобритании и Нижнеканском массиве (Российская Федерация). Техническими и технологическими решениями удается практически полностью исключить внутреннее облучение персонала, а дозы внешнего облучения ограничить диапазоном, характерным и для базовых ядерных технологий. Заключение: планируемые к сооружению, сооружаемые и эксплуатируемые пункты захоронения удаляемых радиоактивных отходов соответствуют действующим в России требованиям безопасности, согласующимся с международными рекомендациями. Оценено, что индивидуальные дозы облучения персонала сопоставимы с данными контроля персонала аналогичных объектов в других странах. Средние индивидуальные дозы облучения персонала при захоронении радиоактивных отходов прогнозируются на порядок ниже установленного предела дозы – 20 мЗв/год. Воздействие на население при нормальной эксплуатации практически исключено установлением санитарно-защитной зоны объекта использования атомной энергии, на которой размещена установка по захоронению отходов, и возможно только при транспортировке радиоактивных отходов по дорогам общего пользования к месту расположения пункта захоронения радиоактивных отходов.