Graduate Occupational Therapy Students: Communication and Research Preferences from Three University Libraries

Library liaisons from three universities distributed an anonymous survey to graduate occupational therapy students to gauge preferred methods of communication when conducting research. This article discusses three findings: whom the students prefer to turn to when seeking research assistance, which methods of communication students prefer, and how long students spend searching before asking for assistance. From 193 responses, the liaisons reasoned that students prefer consulting with their peers before seeking help from librarians or faculty or instructors and they 2 prefer assistance face-to-face. Additionally, the majority are willing to research from 30 minutes to 1 hour before seeking research help

Optical study of the polar BM CrB in low accretion state

This paper presents a spectral and photometric study of the poorly studied polar BM CrB. Three states of the polar brightness and signs of transition from one-pole to two-pole accretion mode were found by an analysis of ZTF data. It is shown that the transition from the low state to the high state changes the longitude of the main accretion spot (by $\approx 17^{\circ}$) and increases its elongation (by $\approx 10^{\circ}$). The spectra contain Zeeman absorptions of the H$\alpha$ line which are formed at a magnetic field strength of $15.5\pm1$ MG. These absorptions are likely produced by a cold halo extending from the accretion spot at $\approx {^1/_4}$ of the white dwarf radius. Modeling of the behavior of the H$\alpha$ emission line shows that the main source of emission is the part of the accretion stream near the Lagrangian point L$_1$, which is periodically eclipsed by the donor star. The spectra exhibit a cyclotron component formed in the accretion spot. Its modeling by a simple accretion spot model gives constraints on the magnetic field strength $B=15-40$ MG and the temperature $T_e\gtrsim15$ keV

Determination of the parameters of polar V379 Vir components, magnetic field and accretion

В данной работе выполнено фотометрическое и спектральное исследование поляра V379 Vir. При определении параметров системы использовались метод моделирования ИК кривых блеска на основе модели точечного источника циклотронного излучения, метод синтетической фотометрии для описания наблюдаемого спектрального распределения энергии, а также метод моделирования магнитной кривой, полученной из величины зеемановского расщепления линии Hβ. Нам удалось оценить температуру белого карлика Teff = 11 450 К, массы и радиусы главной и вторичной компоненты: M1 = 0.696 M , R1 = 0.011 R , M2 = 0.105 M , R2 = 0.14 R . Разделение компонент составило порядка 0.6 а. е., а наклонение орбитальной плоскости i лежит в диапазоне 47—60◦.In this work we performed a photometric and spectral study of the polar V379 Vir. We used the modeling of the IR light curves based on a simple model of cyclotrone radiation source, the method of synthetic photometry to fit the observed spectral distribution of the energy, as well as the modeling of the magnetic curve obtained from Zeeman splitting of the Hβ line to determine the parameters of the system. We managed to estimate the temperature of the white dwarf Teff = 11 450 K, the masses and radii of the primary and secondary components: M1 = 0.696 M , R1 = 0.011 R , M2 = 0.105 M , R2 = 0.14 R . The separation of the components was about 0.6 AU, and the inclination i lies in the range 47—60◦

ВЛИЯНИЕ ПОГОДНЫХ УСЛОВИЙ ВЕГЕТАЦИОННОГО ПЕРИОДА НА УРОЖАЙНОСТЬ ЯРОВОЙ ПШЕНИЦЫ И ЭФФЕКТИВНОСТЬ АЗОТНОГО УДОБРЕНИЯ В ЛЕСОСТЕПИ ПРИОБЬЯ

The purpose of the study is to identify the dependence of spring wheat productivity on agrometeorological indicators of the vegetation period at various levels of nitrogen nutrition in the central forest-steppe of the Ob Region. Wheat of medium early varieties was grown in a wheat-barley crop rotation at doses N0, N30, N60 and N90 against the background of a full range of plant protection products. The correlation between wheat productivity and agrometeorological indicators was evaluated based on the results of 13 years of research. To characterize the hydrothermal conditions, we used the reserve of productive moisture in the soil, the amount of precipitation and air temperature, the Selyaninov hydrothermal coefficient , and the Ponko wetting coefficient. Over the years, grain yield varied from 7.2 to 43.6 kg / ha, Selyaninov coefficient - from 0.18 to 1.67. The highest correlation coefficients (0.7–0.8) were obtained between wheat productivity and indicators of hydrothermal conditions in June - July. Moreover, with the amount of precipitation of this period, the dependence was positive, with air temperature - negative. No reliable relationship was found between grain yield and spring stock of productive moisture in the soil. The tightness of the relationship between wheat productivity and the Selyaninov hydrothermal coefficient and Ponko hydration coefficient was the same, with the highest correlation coefficients also obtained for June – July. The increase in wheat grain from nitrogen fertilizer increased significantly as the hydrothermal conditions of the growing season improved. Based on the obtained values   of the fertilizer nitrogen payback by increasing the crop, it was concluded that the current price ratio - the sale of grain by the farms and their purchase of nitrogen fertilizers (approximately 1:7) is unfavorable for the development of intensive crop cultivation technologies.Цель исследования – выявить зависимость урожайности яровой пшеницы от агрометеорологических показателей вегетационного периода при различных уровнях азотного питания в центральной лесостепи Приобья. Пшеницу среднеранних сортов выращивали в севообороте «пшеница – ячмень» при дозах N0, N30, N60 и N90 на фоне полного комплекса средств защиты растений. Корреляционную связь урожайности пшеницы с агрометеорологическими показателями оценивали по результатам 13 лет исследования. Для характеристики гидротермических условий использовали запас продуктивной влаги в почве, количество осадков и температуру воздуха, гидротермический коэффициент Селянинова, коэффициент увлажнения Понько. За годы исследования урожайность зерна изменялась от 7,2 до 43,6 ц/га, коэффициент Селянинова – от 0,18 до 1,67. Наибольшие коэффициенты корреляции (0,7–0,8) получены между урожайностью пшеницы и показателями гидротермических условий июня – июля. Причем с количеством осадков этого периода зависимость была положительной, с температурой воздуха – отрицательной. Не выявлено достоверной связи между урожайностью зерна и весенним запасом продуктивной влаги в почве. Теснота связи урожайности пшеницы с гидротермическим коэффициентом Селянинова и коэффициентом увлажнения Понько была одинаковой, причем наибольшие коэффициенты корреляции также получены для июня – июля. Прибавки урожайности зерна пшеницы от азотного удобрения значительно возрастали по мере улучшения гидротермических условий вегетационного периода. На основании полученных величин окупаемости азота удобрения прибавкой урожая сделан вывод, что текущее соотношение цен реализации хозяйствами зерна и покупки ими азотных удобрений (примерно 1:7) неблагоприятно для освоения интенсивных технологий возделывания культур

Approaches to Assessing the Safety of Medicines during the COVID-19 Pandemic Using the Example of Azithromycin

Most of the medicines used to treat the novel coronavirus infection (COVID-19) are either approved under an accelerated procedure or not approved for the indication. Consequently, their safety requires special attention.The aim of the study was to review methodological approaches to collecting data on the safety of medicines, using COVID-19 treatment regimens involving azithromycin as a case study.Materials and methods: PubMed® (MEDLINE), Scopus, eLIBRARY, and Cyberleninka databases were searched for publications on azithromycin as part of combination therapy for COVID-19 in 2020–2021. Search queries included names of the medicinal product or its pharmacotherapeutic group and words describing adverse drug reactions (ADRs) during treatment.Results: the analysis included 7 publications presenting the results of studies covering the use of azithromycin as part of COVID-19 combination therapy in more than 4000 patients. Most commonly, the patients receiving COVID-19 therapy including azithromycin developed cardiovascular ADRs (up to 30% of azithromycin prescription cases). In 3 of the analysed publications, safety information was collected through spontaneous reporting and active identification based on the findings of laboratory and instrumental investigations performed during the clinical studies; in other 3, only spontaneous reports were used; and in the last one, ADR database information was studied.Conclusion: currently, information on ADRs associated with the use of medicines is mainly gathered via spontaneous reporting. Direct sourcing of information on personal experiences with a certain product from patients, among other means through social media analysis, opens a promising direction towards the improvement of existing approaches to collecting safety data

Baikal-GVD: status and prospects

Baikal-GVD is a next generation, kilometer-scale neutrino telescope under construction in Lake Baikal. It is designed to detect astrophysical neutrino fluxes at energies from a few TeV up to 100 PeV. GVD is formed by multi-megaton subarrays (clusters). The array construction started in 2015 by deployment of a reduced-size demonstration cluster named "Dubna". The first cluster in its baseline configuration was deployed in 2016, the second in 2017 and the third in 2018. The full scale GVD will be an array of ~10000 light sensors with an instrumented volume of about 2 cubic km. The first phase (GVD-1) is planned to be completed by 2020-2021. It will comprise 8 clusters with 2304 light sensors in total. We describe the design of Baikal-GVD and present selected results obtained in 2015-2017.Comment: 9 pages, 8 figures. Conference proceedings for QUARKS201

Determination of reproductive properties of virulent and vaccine classical swine fever virus strains in primary and continuous cell cultures

Classical swine  fever  (CSF) is a highly dangerous porcine disease. CSF outbreaks are annually notified in several countries. Despite the availability of specific prevention tools, the disease spread risk still persists both at country level and at world level. Hence, the disease surveillance and eradication require highly sensitive methods for early diagnosis of the infection and for tests for the virus circulation in the environment.  Development of up-to-date  diagnostic methods is based on well-established  virus cultivation system; therefore, CSF virus reproduction enhancement,  tests of new cell lines without  endogenous  contamination  for their possible use are still of current importance. The said study was aimed at testing of primary and continuous cell cultures for their susceptibility to classical swine fever virus (vaccine virus strains and some field virus isolates recovered in the Russian Federation) and detection of the virus reproduction dynamics with real-time polymerase chain reaction with fluorescent hybridization probes used for detection. Virus replication intensity in primary and continuous cell cultures was also analyzed. The CSF virus was found incapable of replicating in some cell cultures without  its preliminary adaptation.  Primary porcine and lamb testicle cell cultures grown in minimal essential medium supplemented  with 10% normal CSFV-negative porcine serum instead  of fetal bovine serum were shown to be useful for the virus accumulation, both for vaccine strains and field isolates. Cultivation parameters and optimal minimal essential medium composition contributing to the 4–10-fold  increase in the virus accumulation  both in primary and continuous  cell cultures were determined

АНАЛИЗ ВЛИЯНИЯ НА БЮДЖЕТ ПРИ ПРИМЕНЕНИИ ПРЕПАРАТА РИБОМУСТИН® В ТЕРАПИИ ПЕРВОЙ ЛИНИИ МНОЖЕСТВЕННОЙ МИЕЛОМЫ ДЛЯ ПАЦИЕНТОВ СТАРШЕ 65 ЛЕТ

We have performed the first-ever Budget Impact Analysis (BIA) in a Russian context of bendamustine in the first line of therapy of a multiple myeloma for patients more senior 65 years old with clinical manifestations of a polineuropathy, which autological transplantation of stem cells isn’t shown. Research was conducted from a position of the state health system of the Russian Federation. Within the BIA the analysis of economic efficiency and availability of technology was carried also out to be allowing to estimate expediency of introduction of technology in the presence of the budgetary restrictions. It was as a result shown that use of bendamustine in comparing with strategy of a bortezomib is more preferable strategy from the point of view of BIA: application of a bendamustine allows to keep considerable budget funds – to 159 153 118 rub, thus the saved means allow to treat with this strategy in addition 29 patients during 25 month. It was defined that application of strategy of a bendamustin in comparison with the bortezomib involves smaller load of the budget, thus growth of efficiency is observed for indicator “time to disease progression”.Впервые в российских условиях был проведен анализ влияния на бюджет применения бендамустина в первой линии терапии множественной миеломы у пациентов старше 65 лет, которым не показана аутологичная трансплантация стволовых клеток, с клиническими проявлениями полинейропатии. Исследование было проведено с позиции государственной системы здравоохранения РФ. В рамках анализа влияния на бюджет был также проведен анализ экономической эффективности и доступности технологии, позволяющий оценить целесообразность внедрения той или иной технологии при наличии бюджетных ограничений. В результате было показано, что использование препарата бендамустин при сравнении со стратегией бортезомиба является более предпочтительной стратегией, с точки зрения анализа «влияние на бюджет»: при горизонте моделирования 25 мес. применение бендамустина позволяет сохранить значительные средства бюджета – до 159 153 118 руб., а также пролечить данной стратегией дополнительно до 29 пациентов. В ходе проведения анализа было определено, что применение стратегии бендамустина в сравнении с бортезомибом влечет за собой меньшую нагрузку на бюджет, при этом наблюдается рост эффективности по показателю «время до прогрессирования» (ВДП).

An economic value of the glycated hemoglobin test in diabetes mellitus type 2 diagnosis

BACKGROUND: Diagnostic of diabetes mellitus type 2 (DM2T) in time is very actual for treatment and prevention of potential complications of illness. Fasting blood glucose test (FBG) is a widely used method of primary DM2T diagnose. Glycated hemoglobin (HbA1c) test is an alternative and used more rarely due to expensive. AIM: Modelling of comparative expenditures for DM2T control in cases of primary diagnostic by HbA1c test or FBG test usage in 20-years horizon. METHODS: Retrospective analysis of aggregated epidemiological Russian NATION study data in 810 patients with prediabetes and DM2T with both analysis performed, with sensitivity and specificity of each is detected. The simulation model of DM2T outcomes has been used for Health Technology assessment (direct and indirect costs of Diabetes control during 20 years). Three algorithms of the DM2T treatment were investigated for understanding of expenditures in case on diagnostic on-time and case of late verification with metformin, gliflozines, gliptins, Glucagon-like peptide-1 receptor agonists, basal insulin analogs and their combinations. RESULTS: FBG test has more negative results for DM2T diagnostics in compare with HbA1c analysis (77,4% and 36,5% accordingly). Amount of false negative results in FBG test in 3 times more often occurred in comparison with HbA1c. HbA1c test in 3 times more precisely than FBG test for carbon metabolism abnormalities detection. Diagnostic in time with HbA1c test in compare with late process of illness detection by FBG can cut common expenditures on 26,3-27,7% depending on treatment option due to macrovasular complications decreasing. Disability rate is expected decrease on 21% to 20-th year in case of diagnostic with HbA1c performing instead FBG test. CONCLUSION: HbA1c test has diagnostic advantages in compare with FBG test for primary investigation (dispanserization). Direct and indirect expenditures in average for one patient with DM2T on 20-years horizon including cost of drugs, analysis, complications, disabilities are less in case of diagnostic in time with HbA1c test in comparison with late diagnostics in case of FBG test execution