Big Bang in AdS5AdS_{5} with external field and flat 4d Universe

We describe spontaneous creation of the Brane World in $AdS_{5}$ with external field. The resulting Brane World consists of a flat 4d spatially finite expanding Universe and curved expanding "regulator" branes. No negative tension branes are involved.Comment: Latex, 11 pages, 5 eps figures, references adde

Robust and adaptive passification based consensus control of dynamical networks

An output synchronization problem for networks of dynamical agents is examined based on passification method and recent results in graph theory. Static delayed output feedback controllers of two types are investigated and an adaptive control is proposed. Sufficient conditions for synchronization under incomplete measurements and incomplete control are established. Example of the adaptive synchronization in a network of seven double integrators is presented

ПРОТИВОДЕЙСТВИЕ ЛЕГАЛИЗАЦИИ ПРЕСТУПНЫХ ДОХОДОВ И КОРРУПЦИИ: ФИНАНСОВО-ЭКОНОМИЧЕСКИЕ АСПЕКТЫ

The Russian Federation has a consistent policy to combat money laundering and corruption. The fight against these negative phenomena requires further improvement of the regulatory, supervisory and monitoring and law enforcement efforts as well as focused activities of the government bodies in the financial and economic sphere through the formulation and joint implementation of special measures in this area.The article uses an integrated approach, system analysis, analysis of research results of a wide range of domestic and foreign works, synthesis of managerial decisions.The paper outlines causes and conditions underlying money laundering and corruption and proposes targeted economic and financial measures to prevent and combat these phenomena. The author points out that specific management and organizational measures based on the proposed approach should be worked out and applied. В Российской Федерации проводится последовательная политика по борьбе с легализацией преступных доходов и коррупции. Цель статьи —показать, что эффективное противодействие этим негативным явлениям может быть обеспечено лишь при условии дополнительных мероприятий, осуществляемых в  сферах совершенствования нормативно-правовой, контрольно-надзорной, правоохранительной, правоприменительной деятельности, направленной активностью органов государственного управления в финансово-экономической сфере, через формирование специального комплекса мероприятий в этой сфере. В статье используются комплексный подход, методы системного анализа, анализ результатов научных исследований в виде широкого спектра отечественных и зарубежных работ, метод синтеза управленческих решений. В результате исследования сформирован уточненный комплекс причин и условий феноменов легализации и коррупции, предложен комплекс финансово-экономических мер противодействия данным явлениям. В дальнейшем необходимо отрабатывать конкретные управленческие и организационные мероприятия на основе предложенного подхода.

Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model.

Glutamate plays diverse roles in neuronal cells, affecting cell energetics and reactive oxygen species (ROS) generation. These roles are especially vital for neuronal cells, which deal with high amounts of glutamate as a neurotransmitter. Our analysis explored neuronal glutamate implication in cellular energy metabolism and ROS generation, using a kinetic model that simulates electron transport details in respiratory complexes, linked ROS generation and metabolic reactions. The analysis focused on the fact that glutamate attenuates complex II inhibition by oxaloacetate, stimulating the latter's transformation into aspartate. Such a mechanism of complex II activation by glutamate could cause almost complete reduction of ubiquinone and deficiency of oxidized form (Q), which closes the main stream of electron transport and opens a way to massive ROS generating transfer in complex III from semiquinone radicals to molecular oxygen. In this way, under low workload, glutamate triggers the respiratory chain (RC) into a different steady state characterized by high ROS generation rate. The observed stepwise dependence of ROS generation on glutamate concentration experimentally validated this prediction. However, glutamate's attenuation of oxaloacetate's inhibition accelerates electron transport under high workload. Glutamate-oxaloacetate interaction in complex II regulation underlies the observed effects of uncouplers and inhibitors and acceleration of Ca2+ uptake. Thus, this theoretical analysis uncovered the previously unknown roles of oxaloacetate as a regulator of ROS generation and glutamate as a modifier of this regulation. The model predicted that this mechanism of complex II activation by glutamate might be operative in situ and responsible for excitotoxicity. Spatial-time gradients of synthesized hydrogen peroxide concentration, calculated in the reaction-diffusion model with convection under a non-uniform local approximation of nervous tissue, have shown that overproduction of H2O2 in a cell causes excess of its level in neighbor cells

Decay of metastable current states in one-dimensional resonant tunneling devices

Current switching in a double-barrier resonant tunneling structure is studied in the regime where the current-voltage characteristic exhibits intrinsic bistability, so that in a certain range of bias two different steady states of current are possible. Near the upper boundary V_{th} of the bistable region the upper current state is metastable, and because of the shot noise it eventually decays to the stable lower current state. We find the time of this switching process in strip-shaped devices, with the width small compared to the length. As the bias V is tuned away from the boundary value V_{th} of the bistable region, the mean switching time \tau increases exponentially. We show that in long strips \ln\tau \propto (V_{th} -V)^{5/4}, whereas in short strips \ln\tau \propto (V_{th} -V)^{3/2}. The one-dimensional geometry of the problem enables us to obtain analytically exact expressions for both the exponential and the prefactor of \tau. Furthermore, we show that, depending on the parameters of the system, the switching can be initiated either inside the strip, or at its ends.Comment: 12 pages, 5 figures, update to published versio