Spectral characterizations and antibacterial effect of 2-(5-R-1H-benzimidazol-2-YL)-4-methyl/bromo-phenols and some metal complexes

2-(5-H/Cl/Me/NO2-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL1–HL5) were synthesized. HL1 complexes with Cu(NO3)2, AgNO3, Zn(ClO4)2 and; HL4, HL5 complexes with Zn(ClO4)2 were prepared. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, 1H- and 13C-NMR. Antibacterial activity of the ligands and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria, and the results were compared with penicillin–G and oxytetracycline. While HL1 ligand has considerable antibacterial activity on B. cereus only; it’s Ag(I) complex show antibacterial effect toward almost all the bacteria. It is highly interesting that HL5 and [Zn(HL5)(L5)]ClO4 exhibit considerable high antibacterial activity toward K. pneumoniae, B. cereus, S. epidermidis and B. subtilis. KEY WORDS: Benzimidazole, Phenol, Metal complexes, Antibacterial activity  Bull. Chem. Soc. Ethiop. 2010, 24(3), 391-400

Recovery of dermatophytes in pet grooming tools from veterinary clinics and pet grooming salons

OBJECTIVES: Fomites such as brushes and clippers are known to be potential risk factors for the transmission of dermatophytes between pet animals. The aim of this study was to investigate this risk by examining those grooming implements for the presence of any viable dermatophytes

Preparation, characterization and antibacterial effect of 2-methoxy-6-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)phenols and some transition metal complexes

2-Methoxy-6-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)phenols (HLx; x = 1-4, respectively) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3 and Zn(NO3)(2) were synthesized and characterized. The structures of the compounds were confirmed based on elemental analysis, molar conductivity, magnetic moment, FT-IR, H-1- and C-13-NMR. The antibacterial activity and minimum inhibitory concentration (MIC) of the free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) and the dilution method, respectively, against 9 bacteria. HL1 and HL3, as well as the Cu(II) and Zn(II) complexes, showed antibacterial activity against Gram-positive bacteria

Spectral Characterization and Antibacterial Effect of 2-Methyl-6-(5-H/Me/Cl/NO2-1H-Benzimidazol-2-yl)-Phenols and Some Transition Metal Complexes

2-Methyl-6-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenols (HLx : x = 1-4) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3, Zn(NO3)(2) have been synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, H-1- and C-13-NMR. Antibacterial activity of the free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimum inhibitory concentration dilution method, against nine bacteria. While HL1 ligand has not any activity, it's Ag(I) complex show antibacterial effect toward almost to all the bacteria. Zn(II) complex has antibacterial effect on especially K. pneumoniae, S. epidermidis and S. aureus bacteria

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)-phenols and some transition metal complexes

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol (HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3, and Zn(NO3)(2) were synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and H-1- and C-13-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum inhibitory concentration (MIC) dilution method, against 9 bacteria, and the results were compared with penicillin-G and oxytetracycline. It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L-1)(2)](H2O)(2) are effective on S. epidermidis, S. aureus, and B. subtilis (gram+) organisms compared with the other compounds. All compounds except HL4 and [Zn(L-1)(H2O)(2)]NO3 showed antibacterial activity on S. aureus

Occurrence, species distribution, antimicrobial resistance and clonality of methicillin- and erythromycin-resistant staphylococci in the nasal cavity of domestic animals

beta-Lactams and macrolides are important antibiotics for treatment of staphylococcal infections in both humans and animals. The aim of the study was to investigate the occurrence, species distribution and clonality of methicillin and erythromycin-resistant staphylococci in the nasal cavity of dogs, horses, pigs, and cattle in Denmark. Nasal swabs were collected from a total of 400 animals, including 100 individuals of each species. Methicillin and erythromycin-resistant staphylococci were isolated on selective media, identified by 16S rDNA sequencing, and typed by pulsed field gel electrophoresis (PFGE). Methicillin-resistant coagulase-negative staphylococci (MRCoNS) harbouring mecA were isolated from horses (50%) and dogs (13%), but not from food animals. The species identified were S. haemolyticus (n = 21), S. vitulinus (n = 19), S. sciuri (n = 13), S. epidermidis (n = 8), and S. warneri (n = 2). mecA-mediated methicillin resistance in S. vitulinus was described for the first time. Methicillin-resistant S. aureus was not detected. PFGE analysis revealed the presence of specific MRCoNS clones in samples originating from the same veterinary hospital or equine farm. Erythromycin-resistant S. aureus (ERSA) was detected in 38% of pigs and all isolates harboured a constitutively expressed erm(C) gene. The vast majority (37/38) of pigs carrying ERSA originated from a farm characterized by frequent use of macrolides. Most ERSA isolates (28/38) displayed indistinguishable or closely related PFGE patterns, indicating clonal distribution within the farm. Based on the analysis of data on antimicrobial consumption, the occurrence of MRCoNS in companion animals and that of ERSA in pigs reflected national and local patterns of antimicrobial usage. (c) 2006 Elsevier B.V. All rights reserved