13 research outputs found
Improving Health Industries by the Supply-Chain Policy
Abstractβ the article deals with issues of the policy in the sphere of protection of a Supply-Chain managementβs rights and legitimate interests in the health centres. The issues of protection of the rights of Supply-Chain management in the field of health care revealed. In today's global and national economy, businesses are increasingly relying on outsourcing some of their activities and processes. Therefore, more and more companies at the Supply-Chain level, in specific networks, operate and compete with their suppliers and service providers. This process of outsourcing and the growing importance of supply chains has its consequences in the working conditions and health and safety of workers of supply companies and contractors. There are two main networks of Supply-Chain or relationships between companies and members of their supply chain: the main network (a company and suppliers of its specific goods and materials) and the secondary network (a company and its contractors and subcontractors special services such as activities Maintenance, construction, cleaning or catering This report provides an overview, analysis, conclusions and recommendations on how to upgrade health centers through the above Supply-Chain networks
ΠΠΈΡΡΡ ΠΠΏΡΡΠ΅ΠΉΠ½Π°βΠΠ°ΡΡ Ρ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°ΡΠ°Ρ: ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΡ ΠΈ ΡΠΈΠΊΠ²Π΅Π½ΡΠ½ΡΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΡ ΠΎΠ½ΠΊΠΎΠ³Π΅Π½Π° LMP1
Objective of the investigation was to study the infection of ethnic Tatars with the EpsteinβBarr virus (EBV) and to analyze the genetic structure of the oncogene of the virus, the latent membrane protein 1 (LMP1), in the virus strains of Tatar origin. Materials and methods. The materials for the study were samples of boucle flushes of 60 students from the Kazan State Medical University who are ethnic Tatars (Tatars no less than in the 3rd generation). Amplified from DNA of boucle flushes the nucleotide sequences of the LMP1 samples translated into DNA amino acid sequences, have undergone classification based on the well-known and widely used in literature the R.H. Edwards et al. classification. Results. The analysis of nucleotide and deductive amino acid sequences of the 41 LMP1 amplicons revealed their homology with only three gene variants from the R.H. Edwards et al. classification (1999): 95.8/A (29.3 %; 12/41), Medβ (14.6 %; 6/41) and China1 (7.3 %, 3/41).Β Such variants of LMP1 as Alaskan, Med+, ChinΠ°2, China3 and NC, were not found. Among the LMP1 samples of Tatar origin in 20 cases (48.8 %), the composition of the mutations found did not allow them to be assigned to any of the oncogene variants listed above. Out of this number, in 7 (17.1 %) cases a mono group of LMP1 samples was found, differing not only from representatives of the Slavs, inhabitants of the European part of Russia, but also from other Kazan samples, and was designated as LMP1-TatK. The remaining 13 samples of LMP1 (31.7 %), not belonging to any of the known classifications, formed the group designated by us as an LMP1 group beside the classification (LMP1BC). Conclusion. Continuation of the study of the molecular-biological and functional properties of LMP1 in TatK and BC groups, which constitute 48.8 % of the number of gene samples studied, and an analysis of the peculiarities of the ethnic Tatar genotype, will probably help to clarify whether certain EBV strains influence morbidity and mortality in Tatar population with malignant neoplasms, which include EBVassociated cases.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ Π²ΠΈΡΡΡΠΎΠΌ ΠΠΏΡΡΠ΅ΠΉΠ½Π°βΠΠ°ΡΡ (ΠΠΠ) ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΡΠ°Ρ ΠΈ Π°Π½Π°Π»ΠΈΠ· Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΎΠ½ΠΊΠΎΠ³Π΅Π½Π° Π²ΠΈΡΡΡΠ°, Π»Π°ΡΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° 1 (LMP1), Π² ΡΡΠ°ΠΌΠΌΠ°Ρ
Π²ΠΈΡΡΡΠ° ΡΠ°ΡΠ°ΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ»ΡΠΆΠΈΠ»ΠΈ Π±ΡΠΊΠΊΠ°Π»ΡΠ½ΡΠ΅ ΡΠΌΡΠ²Ρ 60 ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΠ°Π·Π°Π½ΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ°, ΡΠ²Π»ΡΡΡΠΈΡ
ΡΡ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ°ΡΠ°ΡΠ°ΠΌΠΈ (Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΡΠ΅ΠΌ Π² III ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΠΈ). ΠΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ ΠΈΠ· ΡΠΌΡΠ²ΠΎΠ² ΠΠΠ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π΄Π»Ρ Π°ΠΌΠΏΠ»ΠΈΡΠΈΠΊΠ°ΡΠΈ LMP1. ΠΠΌΠΏΠ»ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΈΠ· ΠΠΠ Π±ΡΠΊΠΊΠ°Π»ΡΠ½ΡΡ
ΡΠΌΡΠ²ΠΎΠ² Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΠ΅ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² LMP1, ΡΡΠ°Π½ΡΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π² Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡΠ½ΡΠ΅ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π»ΠΈΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎΠΉ ΠΈ ΡΠΈΡΠΎΠΊΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΠΎΠΉ Π² Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ R.H. Edwards ΠΈ ΡΠΎΠ°Π²Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ½Π°Π»ΠΈΠ· Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΡ
ΠΈ ΡΡΠ°Π½ΡΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡΠ½ΡΡ
ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠ΅ΠΉ 41-Π³ΠΎ Π°ΠΌΠΏΠ»ΠΈΠΊΠΎΠ½Π° LMP1 Π²ΡΡΠ²ΠΈΠ» ΠΈΡ
Π³ΠΎΠΌΠΎΠ»ΠΎΠ³ΠΈΡ ΡΠΎΠ»ΡΠΊΠΎ Ρ 3 Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ Π³Π΅Π½Π° ΠΈΠ· ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ R.H. Edwards ΠΈ ΡΠΎΠ°Π²Ρ.: 95.8/Π (29,3 %; 12/41), Medβ (14,6 %; 6/41) ΠΈ China1 (7,3 %; 3/41). Π’Π°ΠΊΠΈΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΡ LMP1, ΠΊΠ°ΠΊ Alaskan, Med+, ChinΠ°2, China3 ΠΈ NC, Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ. Π ΠΎΡΡΠ°Π»ΡΠ½ΡΡ
20 ΡΠ»ΡΡΠ°ΡΡ
(48,8 %) ΡΠΏΠ΅ΠΊΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΡ
ΠΌΡΡΠ°ΡΠΈΠΉ Π² ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
LMP1 ΡΠ°ΡΠ°ΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π½Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» ΠΈΡ
ΠΎΡΠ½Π΅ΡΡΠΈ Π½ΠΈ ΠΊ ΠΎΠ΄Π½ΠΎΠΌΡ ΠΈΠ· ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΡ
Π²ΡΡΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΎΠ½ΠΊΠΎΠ³Π΅Π½Π°. ΠΠ· Π½ΠΈΡ
Π² 7 ΡΠ»ΡΡΠ°ΡΡ
(17,1 % Π²ΡΠ΅Ρ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ²) ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΠΌΠΎΠ½ΠΎΠ³ΡΡΠΏΠΏΠ° Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² LMP1, ΠΎΡΠ»ΠΈΡΠ°ΡΡΠ°ΡΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΎΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ ΡΠ»Π°Π²ΡΠ½, ΠΆΠΈΡΠ΅Π»Π΅ΠΉ Π΅Π²ΡΠΎΠΏΠ΅ΠΉΡΠΊΠΎΠΉ ΡΠ°ΡΡΠΈ Π ΠΎΡΡΠΈΠΈ, Π½ΠΎ ΠΈ ΠΎΡ Π΄ΡΡΠ³ΠΈΡ
ΠΊΠ°Π·Π°Π½ΡΠΊΠΈΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ², ΠΈ ΠΎΠ±ΠΎΠ·Π½Π°ΡΠ΅Π½Π½Π°Ρ Π½Π°ΠΌΠΈ, ΠΊΠ°ΠΊ LMP1-TatK. ΠΡΡΠ°Π»ΡΠ½ΡΠ΅ 13 ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² LMP1 (31,7 %), Π½Π΅ ΠΎΡΠ½ΠΎΡΡΡΠΈΡ
ΡΡ Π½ΠΈ ΠΊ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π»ΠΈ Π³ΡΡΠΏΠΏΡ, ΠΎΠ±ΠΎΠ·Π½Π°ΡΠ΅Π½Π½ΡΡ Π½Π°ΠΌΠΈ, ΠΊΠ°ΠΊ Π³ΡΡΠΏΠΏΠ° LMP1 Π²Π½Π΅ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ (LMP1ΠΠ). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² LMP1 Π² Π³ΡΡΠΏΠΏΠ°Ρ
ΠΠ ΠΈ TatK, ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΡ
48,8 % ΠΎΡ ΡΠΈΡΠ»Π° ΠΈΠ·ΡΡΠ΅Π½Π½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΎΠ½ΠΊΠΎΠ±Π΅Π»ΠΊΠ°, ΠΈ Π°Π½Π°Π»ΠΈΠ· ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΡΠ°Ρ, Π²Π΅ΡΠΎΡΡΠ½ΠΎ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡ Π²ΡΡΡΠ½ΠΈΡΡ, ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ ΠΠΠ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΈ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ, Π² ΡΠΎΡΡΠ°Π² ΠΊΠΎΡΠΎΡΡΡ
Π²Ρ
ΠΎΠ΄ΡΡ ΠΠΠ-Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠ»ΡΡΠ°ΠΈ, Ρ ΡΠ°ΡΠ°ΡΡΠΊΠΎΠ³ΠΎ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ
Analysis of the Models of Motion of Aqueous Solutions of Polymers on the Basis of Their Exact Solutions
The qualitative properties of solutions of a hereditary model of motion of aqueous solutions of polymers, its modification in the limiting case of short relaxation times, and a similar second grade fluid model are studied. Unsteady shear flows are considered. In the first case, their properties are similar to those of motion of a usual viscous fluid. Other models can include weak discontinuities, which are retained in the course of fluid motion. Exact solutions are found by using the group analysis of the examined systems of equations. These solutions describe the fluid motion in a gap between coaxial rotating cylinders, the stagnation point flow, and the motion in a half-space induced by plane rotation (analog of the Karman vortex). The problem of motion of an aqueous solution of a polymer in a cylindrical tube under the action of a streamwise pressure gradient is considered. In this case, a flow with straight-line trajectories is possible (analog of the Hagen-Poiseuille flow). In contrast to the latter, however, the pressure in the flow considered here depends on all three spatial variables
The Problem of Filling a Spherical Cavity in an Aqueous Solution of Polymers
The problem of filling a spherical cavity in a liquid has attracted the attention of many authors. The study of bubble behavior in liquid allows to estimate the consequences of cavitation processes, which can lead to the intensive destruction of the material surface. Regarding this connection, it becomes necessary to study the influence of impurities, including polymeric additives on the strengthening or suppression of cavitation. In this paper, this problem is considered in three models of a relaxing fluid. It is shown that for all models, the cavity filling time is finite if the surface tension is not equal to zero. This result was previously established for the cases of ideal and viscous fluids. However, the relaxation factor can significantly change the flow pattern by slowing down the filling process and lowering the level of energy accumulation during the bubble collapse
MODERN EPIDEMIOLOGICAL CHARACTERISTICS OF NOROVIRUS INFECTION IN MOSCOW
Aim. Norovirus infection (NVI) epidemiological characteristics evaluation in Moscow at municipal and district levels. Materials and methods. A retrospective analysis of NVI incidence rate was conducted according to the 2009 - 2016 state statistical reporting forms data. Results. In 2009 - 2016 NVI incidence rate has a trend to increase in Moscow, either at municipal and district levels. NVI cases were registered among children mostly (78% in the SEAD of Moscow, 80% in Moscow and 81% in Russia), at the same time adults proportion of NVI incidence rate increased significantly (up to 42,7% in Moscow and 13,9% in the Russian Federation) by 2016. The morbidity dynamics in different child population age groups was effected by the outbreaks cases. Totally in 2011 - 2016 33 outbreaks were registered in Moscow (24,3% from all acute diarrheal infection outbreaks in Moscow for the same period), where 64,3% with nonpercutaneous channel of infection and 35,7% alimentary. Outbreaks were more often recorded in childrenβs organized collectivity (69,7%). Conclusion. Nowadays in Moscow there is an NVI incidence increase trend is evidenced, with an increase of the adult population proportion in morbidity structure. At this stage, main contribution to group morbidity was made by children 7 - 14 and 15 - 17 years old. One of the reasons for the NVI incidence rate growth in Moscow (2016) could possibly be the lack of effective prevention measures. Actually, specific NVI diagnostics provided only in outbreaks, due to the lack of routine diagnostic tools. The main reason for the NVI group morbidity effective disease area formation is still sanitary and anti-epidemic regime violation at sites and facilities
EpsteinβBarr virus in the ethnic Tatars population: the infection and sequence variants of LMP1 oncogene
Objective of the investigation was to study the infection of ethnic Tatars with the EpsteinβBarr virus (EBV) and to analyze the genetic structure of the oncogene of the virus, the latent membrane protein 1 (LMP1), in the virus strains of Tatar origin. Materials and methods. The materials for the study were samples of boucle flushes of 60 students from the Kazan State Medical University who are ethnic Tatars (Tatars no less than in the 3rd generation). Amplified from DNA of boucle flushes the nucleotide sequences of the LMP1 samples translated into DNA amino acid sequences, have undergone classification based on the well-known and widely used in literature the R.H. Edwards et al. classification. Results. The analysis of nucleotide and deductive amino acid sequences of the 41 LMP1 amplicons revealed their homology with only three gene variants from the R.H. Edwards et al. classification (1999): 95.8/A (29.3 %; 12/41), Medβ (14.6 %; 6/41) and China1 (7.3 %, 3/41).Β Such variants of LMP1 as Alaskan, Med+, ChinΠ°2, China3 and NC, were not found. Among the LMP1 samples of Tatar origin in 20 cases (48.8 %), the composition of the mutations found did not allow them to be assigned to any of the oncogene variants listed above. Out of this number, in 7 (17.1 %) cases a mono group of LMP1 samples was found, differing not only from representatives of the Slavs, inhabitants of the European part of Russia, but also from other Kazan samples, and was designated as LMP1-TatK. The remaining 13 samples of LMP1 (31.7 %), not belonging to any of the known classifications, formed the group designated by us as an LMP1 group beside the classification (LMP1BC). Conclusion. Continuation of the study of the molecular-biological and functional properties of LMP1 in TatK and BC groups, which constitute 48.8 % of the number of gene samples studied, and an analysis of the peculiarities of the ethnic Tatar genotype, will probably help to clarify whether certain EBV strains influence morbidity and mortality in Tatar population with malignant neoplasms, which include EBVassociated cases