Stochastic Schr\"odinger equations with coloured noise

A natural non-Markovian extension of the theory of white noise quantum trajectories is presented. In order to introduce memory effects in the formalism an Ornstein-Uhlenbeck coloured noise is considered as the output driving process. Under certain conditions a random Hamiltonian evolution is recovered. Moreover, non-Markovian stochastic Schr\"odinger equations which unravel non-Markovian master equations are derived.Comment: 4pages, revte

Strangeness Production in pp,pA,AA Interactions at SPS Energies.HIJING Approach

In this report we have made a systematic study of strangeness production in proton-proton(pp),proton-nucleus(pA) and nucleus- nucleus(AA) collisions at CERN Super Proton Synchroton energies, using$\,\,\, HIJING\,\,\, MONTE \,\,\,CARLO \,\,\,MODEL$ \\ (version $HIJ.01$). Numerical results for mean multiplicities of neutral strange particles ,as well as their ratios to negatives hadrons($$) for p-p,nucleon-nucleon(N-N),\,\,p-S,\,\,p-Ag,\,\,p-Au('min. bias')collisions and p-Au,\,\,S-S,\,\,S-Ag,\,\,S-Au ('central')collisions are compared to experimental data available from CERN experiments and also with recent theoretical estimations given by others models. Neutral strange particle abundances are quite well described for p-p,N-N and p-A interactions ,but are underpredicted by a factor of two in A-A interactions for $\Lambda,\bar{\Lambda}, K^{0}_{S}$ in symmetric collisions(S-S,\,\,Pb-Pb)and for $\Lambda,\bar{\Lambda}\,\,$in asymmetric ones(S-Ag,\,\,S-Au,\,\,S-W). A qualitative prediction for rapidity, transverse kinetic energy and transverse momenta normalized distributions are performed at 200 GeV/Nucleon in p-S,S-S,S-Ag and S-Au collisions in comparison with recent experimental data. HIJING model predictions for coming experiments at CERN for S-Au, S-W and Pb-Pb interactions are given. The theoretical calculations are estimated in a full phase space.Comment: 33 pages(LATEX),18 figures not included,available in hard copy upon request , Dipartamento di Fisica Padova,report DFPD-94-NP-4

Impressive long-term response with pertuzumab and trastuzumab in HER2-positive breast cancer with brain metastasis

This is a case report of a 40-year-old woman who, after conservative breast cancer treatment, developed a HER2 positive solitary brain metastasis in the left temporal lobe, without extracranial disease. She underwent surgery resection followed by stereotactic radiotherapy and, because of early brain progression, she was submitted to the first line therapy with pertuzumab, trastuzumab and weekly paclitaxel. After six months of treatment, a brain magnetic resonance imaging revealed a complete disappearance of brain recurrence, which persisted for more than 24 months

Hybridization of multi-objective deterministic particle swarm with derivative-free local searches

The paper presents a multi-objective derivative-free and deterministic global/local hybrid algorithm for the efficient and effective solution of simulation-based design optimization (SBDO) problems. The objective is to show how the hybridization of two multi-objective derivative-free global and local algorithms achieves better performance than the separate use of the two algorithms in solving specific SBDO problems for hull-form design. The proposed method belongs to the class of memetic algorithms, where the global exploration capability of multi-objective deterministic particle swarm optimization is enriched by exploiting the local search accuracy of a derivative-free multi-objective line-search method. To the authors best knowledge, studies are still limited on memetic, multi-objective, deterministic, derivative-free, and evolutionary algorithms for an effective and efficient solution of SBDO for hull-form design. The proposed formulation manages global and local searches based on the hypervolume metric. The hybridization scheme uses two parameters to control the local search activation and the number of function calls used by the local algorithm. The most promising values of these parameters were identified using forty analytical tests representative of the SBDO problem of interest. The resulting hybrid algorithm was finally applied to two SBDO problems for hull-form design. For both analytical tests and SBDO problems, the hybrid method achieves better performance than its global and local counterparts

Electrostatic tailoring of magnetic interference in quantum point contact ballistic Josephson junctions

The magneto-electrostatic tailoring of the supercurrent in quantum point contact ballistic Josephson junctions is demonstrated. An etched InAs-based heterostructure is laterally contacted to superconducting niobium leads and the existence of two etched side gates permits, in combination with the application of a perpendicular magnetic field, to modify continuously the magnetic interference pattern by depleting the weak link. For wider junctions the supercurrent presents a Fraunhofer-like interference pattern with periodicity h/2e whereas by shrinking electrostatically the weak link, the periodicity evolves continuously to a monotonic decay. These devices represent novel tunable structures that might lead to the study of the elusive Majorana fermions.Comment: 4.5 pages, 4 color figure

Non Markovian Quantum Repeated Interactions and Measurements

A non-Markovian model of quantum repeated interactions between a small quantum system and an infinite chain of quantum systems is presented. By adapting and applying usual pro jection operator techniques in this context, discrete versions of the integro-differential and time-convolutioness Master equations for the reduced system are derived. Next, an intuitive and rigorous description of the indirect quantum measurement principle is developed and a discrete non Markovian stochastic Master equation for the open system is obtained. Finally, the question of unravelling in a particular model of non-Markovian quantum interactions is discussed.Comment: 22 page

Hidden AGNs in Early-Type Galaxies

We present a stacking analysis of the complete sample of Early Type Galaxies (ETGs) in the \textit{Chandra} COSMOS (C-COSMOS) survey, to explore the nature of the X-ray luminosity in the redshift and stellar luminosity ranges $0<z<1.5$ and {10}^{9}. Using established scaling relations, we subtract the contribution of X-ray binary populations, to estimate the combined emission of hot ISM and AGN. To discriminate between the relative importance of these two components, we (1) compare our results with the relation observed in the local universe $L_{X,gas}\propto L_K^{4.5}$ for hot gaseous halos emission in ETGs, and (2) evaluate the spectral signature of each stacked bin. We find two regimes where the non-stellar X-ray emission is hard, consisten t with AGN emission. First, there is evidence of hard, absorbed X-ray emission in stacked bins including relatively high z ($\sim 1.2$) ETGs with average high X-ray luminosity (L_{X-LMXB}\gtrsim 6\times{10}^{42}\mbox{ erg}/\mbox{s}). These luminosities are consistent with the presence ofhighly absorbed "hidden" AGNs in these ETGs, which are not visible in their optical-IR spectra and spectral energy distributions. Second, confirming the early indication from our C-COSMOS study of X-ray detected ETGs, we find significantly enhanced X-ray luminoaity in lower stellar mass ETGs (L_K\lesssim{10}^{11}L_{\astrosun}), relative to the local $L_{X,gas}\propto L_K^{4.5}$ relation. The stacked spectra of these ETGs also suggest X-ray emission harder than expected from gaseous hot halos. This emission is consistent with inefficient accretion ${10}^{-5}-{10}^{-4}\dot{M}_{Edd}$ onto M_{BH}\sim {10}^{6}-{10}^{8}\,M_{\astrosun}.Comment: 22 pages, 7 figures, 2 tables. Accepted for publications on Ap

A novel ultrafast-low-dose computed tomography protocol allows concomitant coronary artery evaluation and lung cancer screening

BACKGROUND:Cardiac computed tomography (CT) is often performed in patients who are at high risk for lung cancer in whom screening is currently recommended. We tested diagnostic ability and radiation exposure of a novel ultra-low-dose CT protocol that allows concomitant coronary artery evaluation and lung screening. METHODS: We studied 30 current or former heavy smoker subjects with suspected or known coronary artery disease who underwent CT assessment of both coronary arteries and thoracic area (Revolution CT, General Electric). A new ultrafast-low-dose single protocol was used for ECG-gated helical acquisition of the heart and the whole chest. A single IV iodine bolus (70-90 ml) was used. All patients with CT evidence of coronary stenosis underwent also invasive coronary angiography. RESULTS: All the coronary segments were assessable in 28/30 (93%) patients. Only 8 coronary segments were not assessable in 2 patients due to motion artefacts (assessability: 98%; 477/485 segments). In the assessable segments, 20/21 significant stenoses (> 70% reduction of vessel diameter) were correctly diagnosed. Pulmonary nodules were detected in 5 patients, thus requiring to schedule follow-up surveillance CT thorax. Effective dose was 1.3 ± 0.9 mSv (range: 0.8-3.2 mSv). Noteworthy, no contrast or radiation dose increment was required with the new protocol as compared to conventional coronary CT protocol. CONCLUSIONS:The novel ultrafast-low-dose CT protocol allows lung cancer screening at time of coronary artery evaluation. The new approach might enhance the cost-effectiveness of coronary CT in heavy smokers with suspected or known coronary artery disease