1,022 research outputs found
Renal revascularization in Takayasu arteritis–induced renal artery stenosis
AbstractPurposeThis study was undertaken to define the long-term effects of renal revascularization on blood pressure, and renal and cardiac function in patients with Takayasu arteritis–induced renal artery stenosis (TARAS).MethodsTwenty-seven patients (25 women; mean age, 27 years) with TARAS underwent intervention. Primary, primary assisted, and secondary patency rates were determined, and the late effects on blood pressure, renal and cardiac function, and survival were analyzed.ResultsAll patients had hypertension (mean blood pressure, 167/99 mm Hg; 2.5 antihypertensive medications per patient). Mean estimated glomerular filtration rate in patients not receiving hemodialysis was 76 mL/min, and in five patients serum creatinine concentration was greater than 1.5 mg/dL. Three patients were hemodialysis-dependent, and two had intractable congestive heart failure. Forty interventions were performed, including 32 aortorenal bypass procedures, two repeat implantations, four nephrectomies, and two transluminal angioplasty procedures. Postoperative morbidity was 19%. There were no deaths. During follow-up (mean, 68 months), three graft stenoses, all due to intimal hyperplasia, and three graft occlusions occurred. Two of three graft stenoses were successfully revised. At 1, 3, and 5 years of follow-up, primary patency was 87%, 79%, and 79%, respectively; primary assisted patency was 93%, 89%, 89%, respectively; and secondary patency was 93%, 89%, and 89%, respectively. Intervention resulted in a decrease in blood pressure to a mean of 132/79 mm Hg (P < .0001), and the need for antihypertensive medications was reduced to one per patient (P < .01). Mean glomerular filtration rate increased to 88 mL/min (P < .005), and two patients no longer required hemodialysis. Congestive heart failure resolved in both patients, and did not recur. There were three deaths during follow-up, with 5-year and 10-year actuarial survival of 96% and 80%, respectively.ConclusionsRenal revascularization to treat TARAS is durable, has a salutary effect on blood pressure, and enhances long-term renal and cardiac function. This response establishes renal revascularization as a successful and durable intervention for TARAS, and a benchmark to which other therapies should be compared
Tests of Lorentz violation in muon antineutrino to electron antineutrino oscillations
A recently developed Standard-Model Extension (SME) formalism for neutrino
oscillations that includes Lorentz and CPT violation is used to analyze the
sidereal time variation of the neutrino event excess measured by the Liquid
Scintillator Neutrino Detector (LSND) experiment. The LSND experiment,
performed at Los Alamos National Laboratory, observed an excess, consistent
with neutrino oscillations, of in a beam of . It
is determined that the LSND oscillation signal is consistent with no sidereal
variation. However, there are several combinations of SME coefficients that
describe the LSND data; both with and without sidereal variations. The scale of
Lorentz and CPT violation extracted from the LSND data is of order
GeV for the SME coefficients and . This solution for
Lorentz and CPT violating neutrino oscillations may be tested by other short
baseline neutrino oscillation experiments, such as the MiniBooNE experiment.Comment: 10 pages, 10 figures, 2 tables, uses revtex4 replaced with version to
be published in Physical Review D, 11 pages, 11 figures, 2 tables, uses
revtex
Exclusion limits on the WIMP-nucleon cross-section from the Cryogenic Dark Matter Search
The Cryogenic Dark Matter Search (CDMS) employs low-temperature Ge and Si
detectors to search for Weakly Interacting Massive Particles (WIMPs) via their
elastic-scattering interactions with nuclei while discriminating against
interactions of background particles. For recoil energies above 10 keV, events
due to background photons are rejected with >99.9% efficiency, and surface
events are rejected with >95% efficiency. The estimate of the background due to
neutrons is based primarily on the observation of multiple-scatter events that
should all be neutrons. Data selection is determined primarily by examining
calibration data and vetoed events. Resulting efficiencies should be accurate
to about 10%. Results of CDMS data from 1998 and 1999 with a relaxed
fiducial-volume cut (resulting in 15.8 kg-days exposure on Ge) are consistent
with an earlier analysis with a more restrictive fiducial-volume cut.
Twenty-three WIMP candidate events are observed, but these events are
consistent with a background from neutrons in all ways tested. Resulting limits
on the spin-independent WIMP-nucleon elastic-scattering cross-section exclude
unexplored parameter space for WIMPs with masses between 10-70 GeV c^{-2}.
These limits border, but do not exclude, parameter space allowed by
supersymmetry models and accelerator constraints. Results are compatible with
some regions reported as allowed at 3-sigma by the annual-modulation
measurement of the DAMA collaboration. However, under the assumptions of
standard WIMP interactions and a standard halo, the results are incompatible
with the DAMA most likely value at >99.9% CL, and are incompatible with the
model-independent annual-modulation signal of DAMA at 99.99% CL in the
asymptotic limit.Comment: 40 pages, 49 figures (4 in color), submitted to Phys. Rev. D;
v.2:clarified conclusions, added content and references based on referee's
and readers' comments; v.3: clarified introductory sections, added figure
based on referee's comment
Search for Decay in LSND
We observe a net beam-excess of (stat) (syst) events,
above 160 MeV, resulting from the charged-current reaction of
and/or on C and H in the LSND detector. No beam related muon
background is expected in this energy regime. Within an analysis framework of
, we set a direct upper limit for this
branching ratio of at 90% confidence level.Comment: 4 pages, 4 figure
New Results from the Cryogenic Dark Matter Search Experiment
Using improved Ge and Si detectors, better neutron shielding, and increased
counting time, the Cryogenic Dark Matter Search (CDMS) experiment has obtained
stricter limits on the cross section of weakly interacting massive particles
(WIMPs) elastically scattering from nuclei. Increased discrimination against
electromagnetic backgrounds and reduction of neutron flux confirm
WIMP-candidate events previously detected by CDMS were consistent with neutrons
and give limits on spin-independent WIMP interactions which are >2X lower than
previous CDMS results for high WIMP mass, and which exclude new parameter space
for WIMPs with mass between 8-20 GeV/c^2.Comment: 4 pages, 4 figure
Neutrino Oscillations via the Bulk
We investigate the possibility that the large mixing of neutrinos is induced
by their large coupling to a five-dimensional bulk neutrino. In the strong
coupling limit the model is exactly soluble. It gives rise to an oscillation
amplitude whose squared-mass difference is independent of the channel, thus
making it impossible to explain both the solar and the atmospheric neutrino
oscillations simultaneously.Comment: References added and rearranged, typos corrected, a graph added, and
more detailed explanations provided. To appear in Physical Review
Multilevel Contracts for Trusted Components
This article contributes to the design and the verification of trusted
components and services. The contracts are declined at several levels to cover
then different facets, such as component consistency, compatibility or
correctness. The article introduces multilevel contracts and a
design+verification process for handling and analysing these contracts in
component models. The approach is implemented with the COSTO platform that
supports the Kmelia component model. A case study illustrates the overall
approach.Comment: In Proceedings WCSI 2010, arXiv:1010.233
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