Role of Cerebellar Interpositus Nucleus in the Genesis and Control of Reflex and Conditioned Eyelid Responses

The role of cerebellar circuits in the acquisition of new motor abilities is still a matter of intensive debate. To establish the contribution of posterior interpositus nucleus (PIN) to the performance and/or acquisition of reflex and classically conditioned responses (CRs) of the eyelid, the effects of microstimulation and/or pharmacological inhibition by muscimol of the nucleus were investigated in conscious cats. Microstimulation of the PIN in naive animals evoked ramp-like eyelid responses with a wavy appearance, without producing any noticeable plastic functional change in the cerebellar and brainstem circuits involved. Muscimol microinjections decreased the amplitude of reflex eyeblinks evoked by air puffs, both when presented alone or when paired with a tone as conditioned stimulus (CS). In half-conditioned animals, muscimol injections also decreased the amplitude and damped the typical wavy profile of CRs, whereas microstimulation of the same sites increased both parameters. However, neither muscimol injections nor microstimulation modified the expected percentage of CRs, suggesting a major role of the PIN in the performance of eyelid responses rather than in the learning process. Moreover, the simultaneous presentation of CS and microstimulation in well trained animals evoked CRs similar in amplitude to the added value of those evoked by the two stimuli presented separately. In contrast, muscimol-injected animals developed CRs to paired CS and microstimulation presentations, larger than those evoked by the two stimuli when presented alone. It is concluded that the PIN contributes to the enhancement of both reflex and conditioned eyelid responses and to the damping of resonant properties of neuromuscular elements controlling eyelid kinematics

Mechanisms of nonlinear spin-wave emission from a microwave driven nanocontact

We present a micromagnetic study of linear and nonlinear spin-wave modes excited in an extended permalloy thin film by a microwave driven nanocontact. We show that the linear mode having the frequency equal to the excitation frequency (f) is driven by the ac Oersted field component perpendicular to the static external field (applied in-plane of the sample). The nonlinear mode with the frequency f /2 is excited as an independent eigenmode within a parametric longitudinal pumping process (due ac Oersted field component parallel to the bias field). Spectral positions of those modes are determined both in the space and phase domain. The results are important for the transfer of information coded into spin-waves between nanocontacts, and for synchronization of spin transfer torque nano-oscillators.Comment: 5 pages, 4 figure

Severe Heat Cramps in a High School Football Player: A Case Report

We present a case study of an adolescent football player who suffered from severe full body muscle cramping after supplementing with creatine for two months. A paucity of data exists regarding the safety of creatine supplementation and its side effects on dehydration, body fluid/electrolyte balance, and other heat illnesses

Empowering Citizen-Centric Innovation for Effective Smart City Initiatives: A Location Intelligence Perspective

The world population continues to inhabit and move toward urban areas. This global population shift has dramatically changed the notion of a modern city even from a few decades ago. Many cities have turned to digital technologies in response to rapid growth and demographic changes. Such technologies rely on sophisticated sensor networks (van Zoonen, 2016; El-Haddadeh et al., 2019), infrastructure modernization (Khatoun & Zeadally, 2016), and advances in efficiency and sustainability (Sakurai & Kokuryo, 2018) to ensure outcomes related to a higher quality of life (Gascó-Hernandez, 2018). Researchers have examined participatory government and location intelligence in the context of smart cities. We expand on this work by exploring a) how citizen sensing methods can provide dynamic location-based data collection, b) how interactive location analytics can foster citizen engagement and participation, and c) how geo-visualization can improve citizen awareness. Citizen sensing is a method of deploying citizens and mobile devices to collect essential data for smart cities. Citizen engagement and participation determine how to include citizens in smart city decision-making. Citizen awareness addresses how smart cities can impart essential information to their citizens. Smart governance, such as public participation in decision making, policies and regulation, and urban digitization, can empower citizen-centric innovation. Similarly, citizen-driven initiatives, including participation in public life and an affinity to contribute to their social fabric, also lead to innovation. Therefore, our work will utilize a case approach by capturing the perspectives of official representatives and citizen groups. Moreover, our study will rely on semi-structured interviews with individuals representing municipalities in various countries (e.g., Brazil, Columbia, Germany, and the United States)

High Gain Amplifier with Enhanced Cascoded Compensation

A two-stage CMOS operational amplifier with both, gain-boosting and indirect current feedback frequency compensation performed by means of regulated cascode amplifiers, is presented. By using quasi-floating-gate transistors (QFGT) the supply requirements, the number of capacitors and the size of the compensation capacitors respect to other Miller schemes are reduced. A prototype was fabricated using a 0.5 μm technology, resulting, for a load of 45 pF and supply voltage of 1.65 V, in open-loop-gain of 129 dB, 23 MHz of gain-bandwidth product, 60o phase margin, 675 μW power consumption and 1% settling time of 28 ns

Aetiology and Treatment Outcome of Non-traumatic Small Bowel Perforations at Mbarara Hospital in South-Western Uganda

Background: Non-traumatic small bowel perforation (SBP) is the most common form of gastrointestinal perforation in sub-Saharan Africa. Although SBP is a surgical emergency associated with complications, information regarding its aetiology is scanty in Uganda. This study was aimed at determining the aetiology and document treatment outcomes of non-traumatic small bowel perforations in South-western Uganda. Methods: This was a descriptive case series of 87 consenting patients with non-traumatic SBP confirmed at laparotomy, on the emergency ward of Mbarara University Teaching Hospital. They were enrolled from September 2011 to May 2012. Specimens for blood culture, stool microscopy, HIV testing and tissue biopsies at the site of perforation were collected and analyzed. Patient follow-up was done till discharge. Results: Of the 78 biopsies performed, 66(84.6%) had histological features suggestive of typhoid perforations while 12(15.4%) had features of non-specific inflammation. Salmonella typhi was isolated in 13(15.0%) out of the 87 patients. Isolates were susceptible to Ceftriaxone and Ciprofloxacin. All patients tested HIV negative. Ascaris lumbricoides were seen in two patients. Re-laparotomy was done in four patients with new perforations, two with anastomotic breakdown and two with intra-abdominal abscesses. Wound sepsis was observed in 25(28.7%). Average length of hospital stay was 13 days. Some 10(11.5%) patients died. Conclusions: Most cases of non-traumatic SBP in south western Uganda are associated with Salmonella infection. There is need to enhance laboratory capacity to detect typhoid and preventive measures should be instituted in the general population