Inflammation and endothelial activation in benign prostatic hyperplasia and prostate cancer

PURPOSE: Emerging insights underline a link among chronic inflammation and endothelial activation with benign prostatic hyperplasia (BPH) and prostate cancer (PCa). We aim to investigate whether specific plasma markers of inflammation and endothelial activation allow to discriminate BPH and PCa. MATERIALS AND METHODS: Fifteen patients affected by BPH, 15 by PCa and 15 controls, were enrolled. Interleukin-6 (IL-6), CD40 ligand (CD40L), endothelial-selectin (E-selectin), platelet-selectin (P-selectin), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were measured. RESULTS: In systemic blood samples, IL-6 has been found increased in patients affected by BPH (4.25 ± 0. pg/mL) and PCa (5.08 ± 0.24) respect to controls (2.62 ± 0.34; p < 0.05). CD40L was higher in BPH (4.25 ± 0.65 ng/mL; p < 0.05) than in control (2.31 ± 0.20) and PCa group (2.60 ± 0.56). E-selectin, P-selectin and VCAM-1 did not show any significant difference. Higher levels of ICAM-1 were detected in patients with PCa (573.04 ± 52.23) and BPH (564.40 ± 74.67) than in the controls (215.30 ± 11.53 ng/mL; p < 0.05). In local blood samples, IL-6 has been found significantly increased in PCa in comparison with patients with BPH; there was no difference in CD40L, E-selectin, P-selectin, VCAM-1 ed ICAM-1. CONCLUSIONS: Changes in inflammation and endothelial activation markers may be not considered to be of value in discriminating BPH and PCa

INJECTION D'IONS LOURDS DANS LE CYCLOTRON A ÉNERGIE VARIABLE D'ORSAY

Préaccélérés à 1 MeV par nucléon, les ions lourds traversent une feuille mince dans la région centrale du cyclotron. Ils sont ensuite accélérés avec une charge beaucoup plus grande que celle fournie par une source d'ions multichargés. Les nouvelles possibilités de cette machine, son rendement et la variation de l'énergie, sont analysés.Heavy ions, preaccelerated at 1 MeV/a. m. u., pass through a thin foil, in the central region of the cyclotron. At this stage, they are accelerated with a much higher electronic charge than the charge produced by a multicharged ion source. We analyse the new capabilities, the efficiency and the ability of varying the energy of the machine

Méthodes permettant d'améliorer la structure en temps du faisceau externe du synchrocyclotron

The object was to modify the time distribution of the synchrocyclotron external beam in order to increase the yield of particle measurement devices. The pulse repetition frequence was raised from 450 per second to 40 000 per second, and there are pratically no more « dead times ».Le but recherché était de modifier la distribution dans le temps du faisceau externe du synchrocyclotron afin d'augmenter le rendement des appareils de mesure des particules. La fréquence de répétition des impulsions a pu être portée de 450 par seconde à 40 000 et il n'y a pratiquement plus de « temps mort »