Sociocultural Risk Factors for Elevated Perceived Stress among African American Smokers

Introduction: African Americans experience unique stressors that may inhibit smoking cessation and enhance relapse rates. Few studies, however, have focused on risk factors for perceived stress among treatment seekers. Because African Americans are less likely to quit compared to the larger community, understanding factors associated with perceived stress among smokers has the potential to improve intervention outcomes. This study examined psychosocial and cultural correlates of stress in a sample of African American participants in a randomized controlled trial. Methods: At baseline, participants reported demographic factors and completed assessments of smoking history, alcohol use, friend and household smoking, weight concerns, acculturation, depressive symptoms, and perceived stress (N = 325). Bivariate associations were examined, followed by multiple regression analyses to test independent relationships. The sample was comprised of mostly middle-aged males, with at least a high school education, who were single, and reported low household income. Participants were moderately nicotine dependent and smoked 18 cigarettes per day for 26 years. Results: Perceived stress was inversely associated with age (r = -.16, p = .004), education (r = -.11, p = .04), household income (r = -.11, p = .047), and positively associated with being male (r = .13, p = .02). Stress perceptions were positively related to cigarettes per day (r = .11, p = .049), nicotine dependence (r = .20, p = .001), drinking frequency (r = .15, p = .008), drinking intensity (r = .14, p=.02), and inversely related to smoking duration (r = -.12, p = .03). We found positive associations between perceived stress and household smokers (r = .18, p = .004), and friends who smoke (r = .15, p = .01). Perceived stress was also positively associated with post-cessation weight concern (r = .14, p = .01), a traditional African American cultural orientation; r = .12, p = .04), and depressive symptoms (r = .65, p Conclusion: These findings have important intervention implications. Many of the risk factors for distress among African American smokers are modifiable. Interventions should prioritize addressing depression, household smoking environment, and stress among younger smokers, in addition to managing other stress-enhancing concerns like alcohol use

Probing Exotic Physics With Cosmic Neutrinos

Traditionally, collider experiments have been the primary tool used in searching for particle physics beyond the Standard Model. In this talk, I will discuss alternative approaches for exploring exotic physics scenarios using high energy and ultra-high energy cosmic neutrinos. Such neutrinos can be used to study interactions at energies higher, and over baselines longer, than those accessible to colliders. In this way, neutrino astronomy can provide a window into fundamental physics which is highly complementary to collider techniques. I will discuss the role of neutrino astronomy in fundamental physics, considering the use of such techniques in studying several specific scenarios including low scale gravity models, Standard Model electroweak instanton induced interactions, decaying neutrinos and quantum decoherence.Comment: 11 pages, 6 figures; For the proceedings of From Colliders To Cosmic Rays, Prague, Czech Republic, September 7-13, 200

A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness.

Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n = 22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n = 14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n = 52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P < 0.001) from 68 ± 14 (60-102) at 1300 m to 183 ± 107 (65-519); 143 ± 66 (60-315) and 150 ± 71 (60-357) at 3400 m, 4270 m and 5150 m respectively. At 5150 m there was a significant difference in NGAL between those with severe AMS (n = 7), mild AMS (n = 16) or no AMS (n = 23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P = 0.009 for severe versus no AMS; P = 0.026 for mild versus no AMS). In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS

Determination of the Alignment between Information Systems and Marketing

This paper addresses the challenge of measuring alignment. Two different approaches are developed: one based on seven dimensions of strategic orientation; and one based on eight dimensions of market orientation. A formula is developed for the calculation of alignment. The formula is applied to a survey of 175 large New Zealand companies. Analyses of the results suggest overall similarity between the strategic orientation and market orientation approaches, yet with distinct differences which might impact on business performance

Public perceptions of tidal energy: Can you predict social acceptability across coastal communities in England?

Early consideration of potential societal issues faced by the nascent tidal industry is important to facilitate public engagement and potentially avoid levels of conflict that have arisen within other renewable energy sectors; general expressions of public support (as reported in national-scale attitude surveys) do not always translate into approval for local developments. It is a very appealing idea that the likely response of different types of communities to marine energy developments can be mapped and used to support planning. This study examined the attitudes of 963 people in South West England to hypothetical local tidal energy projects, analysing the results both by geographic location and according to the coastal community typology developed for England by the Marine Management Organisation. With the exception of age, demographic variables had little influence on the level of opposition to tidal energy, which instead was affected more by factors such as attitudes towards tidal energy in general (in particular its likely environmental impact), activities undertaken at the coast, and place attachment. These significant factors are typically not captured by the national census data used to determine community types. Any predictions about the acceptability of energy projects made as a result of community mapping based on demographic variables will not be a substitute for thorough public engagement and consultation, which should centre on the implications of tidal developments for the environment

Evaluating Banking Websites Privacy Statements – A New Zealand Perspective on Ensuring Business Confidence

Because banks deal with highly personal detailed and sensitive information, they need to establish and maintain the confidence of their customers more assiduously than most other businesses. The rise of internet banking and the advantages to be gained from the garnering of personal data from websites places banks in a position to exploit customer data in a way that might infringe ethical considerations. This investigation analyses the website privacy statements of New Zealand banks in terms of the provisions of the New Zealand Privacy Act. The intention was to find an objective basis for the assessment of business integrity, to explore how confidence in electronic commerce can be assured. The investigation finds that the use of privacy legislation principles as a means of evaluating website privacy statements is revealing and convincing. It is considered that customer confidence will increasingly impact on Internet businesses, and business integrity as demonstrated by comprehensive and relevant privacy statements will go a long way to provide those assurances

Wind-profiler observations of gravity waves produced by convection at mid-latitudes

This work presents a case study which includes regions of large rapidly varying vertical velocities observed by a VHF wind-profiler at Aberystwyth (52.4&deg; N, 4.1&deg; W). Analysis indicates that this region is associated with gravity waves above the tropopause level and simultaneous regions of convective activity below the tropopause level. This case study also suggests that convective activity can be identified effectively by finding periods of large uncertainties on the derived velocities. These regions are hypothesized to be related to regions of small-scale inhomogeneity in the wind field. Examination suggests that the large vertical velocity fluctuations above these convective regions are short period gravity wave packets as expected from theory. In addition the vertical flux of the horizontal momentum associated with the gravity waves also displays the pattern of reversal observed in previous studies