11 research outputs found

    Developing Creative Potential of Future Teachers: Research and Results

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    AbstractThe total globalization and integration of national education into global educational space requires a higher quality of vocational training of future teachers whose competence and creative activeness significantly affects the level of intellectual potential of society. The relevance of this issue becomes more important given the tendency of decrease in students’ motivation to learn, to acquire basic academic school knowledge. This makes it necessary to find innovational approaches in educating of future teachers during the process of vocational training.One of these approaches employs a purposeful development of creative potential among future teachers through introduction of innovational interactive educative methods into the training process which would encourage maximal development of their self-actualization, self-realization and self-improvement. This article gives consideration to the main results in experimental work on purposeful maturation of preparedness of future teachers to creative pedagogical work in university

    Genetic, social, and behavioral risk factors for tuberculosis: preliminary results from a matched case-control study in Kazakhstan

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    We designed a case-control study to examine demographic, clinical, social and cultural factors associated with tuberculosis in four regions of Kazakhstan. Cases included persons identified by the national tuberculosis program as having primary pulmonary tuberculosis, and controls were healthy household members and randomly selected community residents

    Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage

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    Correction of phenotypic plasticity of macrophages for reprogramming inflammatory response is of great interest to modern medicine. To date, there are lots of factors, which can alter macrophages' phenotype to M1 or M2. The introduction of drug containing autologous erythrocyte ghosts is one of such factors. We have developed a method for the targeted delivery of autologous erythrocyte ghosts loaded with antibiotic (pharmacocytes) directly into the wound tissues. Introduction of pharmacocytes to the purulent wound ensures high therapeutic concentrations of the antibiotic, which leads to rapid arresting of the phase of the inflammatory process and thus results in early healing. In order to explain this phenomenon, we investigated the effect of the pharmacocytes on the phenotypic polarization of macrophages

    Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage

    No full text
    Correction of phenotypic plasticity of macrophages for reprogramming inflammatory response is of great interest to modern medicine. To date, there are lots of factors, which can alter macrophages' phenotype to M1 or M2. The introduction of drug containing autologous erythrocyte ghosts is one of such factors. We have developed a method for the targeted delivery of autologous erythrocyte ghosts loaded with antibiotic (pharmacocytes) directly into the wound tissues. Introduction of pharmacocytes to the purulent wound ensures high therapeutic concentrations of the antibiotic, which leads to rapid arresting of the phase of the inflammatory process and thus results in early healing. In order to explain this phenomenon, we investigated the effect of the pharmacocytes on the phenotypic polarization of macrophages

    Tuberculosis report among injection drug users and their partners in Kazakhstan

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    Abstract ObjectivesTuberculosis (TB) is a major threat to global public health. Kazakhstan has the second highest percentage of multidrug-resistant tuberculosis (MDR-TB) cases among incident tuberculosis cases in the world (WHO 2013). A high burden of MDR-TB suggests TB prevention, control, and treatment programs are failing. This study provides an epidemiologic profile of TB among injection drug users (IDUs), a high-risk and chronically underserved population, in Kazakhstan. Study designCross-sectional study. MethodsThe authors studied the characteristics and risk environment of IDUs with self-reported previous active TB and their primary sexual partners in Almaty, Kazakhstan. 728 individuals (364 couples) participated in a couple-based study in 2009. Results16.75% of participants reported at least one positive TB test (x-ray) in their lifetime. In a multivariable logistic regression adjusting for couple-based sampling, persons with positive TB test were significantly more likely to be older (odds ratio (OR) 7.26, 95% confidence interval (CI): 1.73, 30.43), male (OR 5.53, 95% CI: 2.74, 11.16), have a shorter duration of injection drug use (OR 0.17, 95% CI: 0.04, 0.65), have received high social support from their significant other (OR 2.13, 95% CI: 1.03, 4.40) and more likely (non-significantly) to have been incarcerated (OR 7.03, 95% CI: 0.64, 77.30). ConclusionsOlder men with a history of incarceration and recent injection drug use were more likely to have positive TB test in Kazakhstan. Social network support, while potentially positive for many aspects of population health, may increase risk of TB among IDUs in this context. Public health policies that target high-risk populations and their at-risk networks may be necessary to stem the rise of MDR-TB in Central Asia
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