51 research outputs found
A Multicellular Model of Intestinal Crypt Buckling and Fission
Crypt fission is an in vivo tissue deformation process that is involved in both intestinal homeostasis and colorectal tumourigenesis. Despite its importance, the mechanics underlying crypt fission are currently poorly understood. Recent experimental development of organoids, organ-like buds cultured from crypt stem cells in vitro, has shown promise in shedding light on crypt fission. Drawing inspiration from observations of organoid growth and fission in vivo, we develop a computational model of a deformable epithelial tissue layer. Results from in silico experiments show the stiffness of cells and the proportions of cell subpopulations affect the nature of deformation in the epithelial layer. In particular, we find that increasing the proportion of stiffer cells in the layer increases the likelihood of crypt fission occurring. This is in agreement with and helps explain recent experimental work
Quantitative studies of cytological damage in mouse testis produced by exposure to heat.
An investigation into the efficient use of time in the calorimetric measurement of heat output
Cytological organization of gastric glands, crypts of the small intestine, and adrenal cortex in rats
The effect of air movement on the activity, lying position and huddling behaviour of weaned piglets
Autoradiographic investigation of proliferation and migration of the intestinal epithelium after gastrectomy
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