Front Form Spinors in Weinberg-Soper Formalism and Melosh Transformations for any Spin

Using the Weinberg-Soper formalism we construct the front form $(j,0)\oplus(0,j)$ spinors. Explicit expressions for the generalised Melosh transformations up to spin two are obtained. The formalism, without explicitly invoking any wave equations, reproduces spin one half front-form results of Melosh, Lepage and Brodsky, and Dziembowski.Comment: 16 Pages, RevTex. We continue to receive reprint requests for this paper. So we now archive it her

Topical glucocorticoids and the skin--mechanisms of action: an update.

The topical glucocorticoids (GCs) represent the treatment of choice for many types of inflammatory dermatoses. Despite the extensive use of this class of drugs as first line therapy the mechanism of their action is uncertain. It is clear that the multiplicity of actions of the topical GCs is an important facet of their scope in the treatment of dermal disorders. The aim of this update is to review past and current theories regarding how these agents might work. Current understanding of the molecular mechanisms of GC action has advanced significantly over the past decade with the realisation that multiple systems are responsible for transduction of GC effects at a molecular level. The two primary modes of action are via interaction directly with DNA or indirectly through modulation of specific transcription factors: the endpoint in both cases being modulation of specific protein synthesis. Both of these mechanisms will be discussed. In particular this review will concentrate on the possibility that a GC-inducible protein, termed lipocortin 1, may have a significant role to play in the anti-inflammatory actions of these drugs. Additionally it has become apparent that several inflammatory enzymes induced in inflammation are sites of inhibitory action of the GCs, and the possibility that this occurs in the skin will be discussed paying particular attention to the inducible phospholipase A2, nitric oxide synthase and cyclooxygenase systems

Phase field simulations of coupled phase transformations in ferroelastic-ferroelastic nanocomposites

We use phase field simulations to study composites made of two different ferroelastics (e.g., two types of martensite). The deformation of one material due to a phase transformation can elastically affect the other constituent and induce it to transform as well. We show that the phase transformation can then occur above its normal critical temperature and even higher above this temperature in nanocomposites than in bulk composites. Microstructures depend on temperature, on the thickness of the layers, and on the crystal structure of the two constituents -- certain nanocomposites exhibit a great diversity of microstructures not found in bulk composites. Also, the periodicity of the martensite twins may vary over 1 order of magnitude based on geometry. keywords: Ginzburg-Landau, martensitic transformation, multi-ferroics, nanostructure, shape-memory alloyComment: 8 pages, 15 figure

On the spin of gravitational bosons

We unearth spacetime structure of massive vector bosons, gravitinos, and gravitons. While the curvatures associated with these particles carry a definite spin, the underlying potentials cannot be, and should not be, interpreted as single spin objects. For instance, we predict that a spin measurement in the rest frame of a massive gravitino will yield the result 3/2 with probability one half, and 1/2 with probability one half. The simplest scenario leaves the Riemannian curvature unaltered; thus avoiding conflicts with classical tests of the theory of general relativity. However, the quantum structure acquires additional contributions to the propagators, and it gives rise to additional phases.Comment: Honorable mention, 2002 Gravity Research Foundation Essay

Domain Size Dependence of Piezoelectric Properties of Ferroelectrics

The domain size dependence of piezoelectric properties of ferroelectrics is investigated using a continuum Ginzburg-Landau model that incorporates the long-range elastic and electrostatic interactions. Microstructures with desired domain sizes are created by quenching from the paraelectric phase by biasing the initial conditions. Three different two-dimensional microstructures with different sizes of the $90^{o}$ domains are simulated. An electric field is applied along the polar as well as non-polar directions and the piezoelectric response is simulated as a function of domain size for both cases. The simulations show that the piezoelectric coefficients are enhanced by reducing the domain size, consistent with recent experimental results of Wada and Tsurumi (Brit. Ceram. Trans. {\bf 103}, 93, 2004) on domain engineered $BaTiO_{3}$Comment: submitted to Physical Review

The NITRATE-CIN Study: A randomised, double-blind placebo-controlled trial testing the effect of inorganic nitrate on contrast-induced nephropathy in patients undergoing coronary angiography for acute coronary syndromes

Background and Aims Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-risk patients and remains a significant unmet need. In pre-clinical studies inorganic nitrate, which is chemically reduced in vivo to nitric oxide, is renoprotective but this observation is yet to be translated clinically. In this study, the efficacy of inorganic nitrate in the prevention of CIN in high-risk patients presenting with acute coronary syndromes (ACS) is reported. Methods NITRATE-CIN is a double-blind, randomized, single-centre, placebo-controlled trial assessing efficacy of inorganic nitrate in CIN prevention in at-risk patients presenting with ACS. Patients were randomized 1:1 to once daily potassium nitrate (12 mmol) or placebo (potassium chloride) capsules for 5 days. The primary endpoint was CIN (KDIGO criteria). Secondary outcomes included kidney function [estimated glomerular filtration rate (eGFR)] at 3 months, rates of procedural myocardial infarction, and major adverse cardiac events (MACE) at 12 months. This study is registered with ClinicalTrials.gov: NCT03627130. Results Over 3 years, 640 patients were randomized with a median follow-up of 1.0 years, 319 received inorganic nitrate with 321 received placebo. The mean age of trial participants was 71.0 years, with 73.3% male and 75.2% Caucasian; 45.9% had diabetes, 56.0% had chronic kidney disease (eGFR <60 mL/min) and the mean Mehran score of the population was 10. Inorganic nitrate treatment significantly reduced CIN rates (9.1%) vs. placebo (30.5%, P < .001). This difference persisted after adjustment for baseline creatinine and diabetes status (odds ratio 0.21, 95% confidence interval 0.13–0.34). Secondary outcomes were improved with inorganic nitrate, with lower rates of procedural myocardial infarction (2.7% vs. 12.5%, P = .003), improved 3-month renal function (between-group change in eGFR 5.17, 95% CI 2.94–7.39) and reduced 1-year MACE (9.1% vs. 18.1%, P = .001) vs. placebo. Conclusions In patients at risk of renal injury undergoing coronary angiography for ACS, a short (5 day) course of once-daily inorganic nitrate reduced CIN, improved kidney outcomes at 3 months, and MACE events at 1 year compared to placebo

Discrete quantum gravity: a mechanism for selecting the value of fundamental constants

Smolin has put forward the proposal that the universe fine tunes the values of its physical constants through a Darwinian selection process. Every time a black hole forms, a new universe is developed inside it that has different values for its physical constants from the ones in its progenitor. The most likely universe is the one which maximizes the number of black holes. Here we present a concrete quantum gravity calculation based on a recently proposed consistent discretization of the Einstein equations that shows that fundamental physical constants change in a random fashion when tunneling through a singularity.Comment: 5 pages, RevTex, 4 figures, honorable mention in the 2003 Gravity Research Foundation Essays, to appear in Int. J. Mod. Phys.

Neutrino oscillations with disentanglement of a neutrino from its partners

We bring attention to the fact that in order to understand existing data on neutrino oscillations, and to design future experiments, it is imperative to appreciate the role of quantum entanglement. Once this is accounted for, the resulting energy-momentum conserving phenomenology requires a single new parameter related to disentanglement of a neutrino from its partners. This parameter may not be CP symmetric. We illustrate the new ideas, with potentially measurable effects, in the context of a novel experiment recently proposed by Gavrin, Gorbachev, Veretenkin, and Cleveland. The strongest impact of our ideas is on the resolution of various anomalies in neutrino oscillations and on neutrino propagation in astrophysical environments.Comment: 6 page

On helicity and spin on the light cone

Starting from a one-body front-form equation with Lepage-Brodsky spinors we show, with a fair amount of new technology, how an integral equation in standard momentum space with Bjorken-Drell spinors can be obtained. The integral equation decouples for singlets and triplets.Comment: LaTeX2e, 5 pages, 11 references. to be published in Nucl. Phys. B (Proc. Suppl.) Talk presented at the Workshop "Light-cone Physics: Particles and Strings" at ECT* in Trento, Sep 3-11, 200