New technologies in morphological diagnostics

Currently, lifetime morphological studies have an important place in the diagnostic process. The results of morphological studies determine the algorithm of medical tactics. Modern morphological diagnostics is characterized by a higher degree of reliability as a result of the creation and introduction into practice of modern high-tech equipment and new research methods. Morphological diagnostics in 1–2 days sets new standards in diagnostic and therapeutic work.В настоящее время прижизненные морфологические исследования занимают важное место в диагностическом процессе. Результаты морфологического исследования определяют алгоритм врачебной тактики. Современная морфологическая диагностика характеризуется более высокой степенью достоверности в результате создания и внедрения в практику современного высокотехнологичного оборудования и новых методик исследования. Морфологическая диагностика за 1—2 дня устанавливает новые стандарты в диагностической и лечебной работе

3D RECORDING OF A 19-CENTURY OB RIVER SHIP

A 3D recording of a 19-century wooden ship discovered on the bank of the river Ob (Western Siberia) was performed in autumn 2015. The archaeologized ship was partly under water, partly lying ashore, buried under fluvial deposits. The 3D recording was performed in October, when the water level was at its lowest after clearing the area around the ship. A 3D recording at the place of discovery was required as part of the ship museumification and reconstruction project. The works performed were primarily aimed at preserving as much information about the object as possible. Given the location and peculiar features of the object, a combination of close-range photogrammetry and aerial photography was considered to be the best possible solution for creating a high-quality 3D model. The dismantled ship was delivered to Nizhnevartovsk Museum of Local History in October 2015. The ship is going to be reassembled using the created 3D model to be exhibited in the museum. The resulting models are also going to be used to make a virtual 3D reconstruction of the ship in the future. We shot a stereoscopic video for Nizhnevartovsk Museum of Local History to let visitors see the place of discovery and explore the ship in greater details. Besides, 3D printing allowed for creating a miniature of the ship, which is also going to be included in the exposition devoted to this unique discovery

Comprehensive analysis of clinical and social factors influencing the emergence autoaggressive behavior in of military age

Clinical method were used to examine 200 young men of draft age having autoagresstive actions in the anamnesis. It was revealed a complex clinical-psychopathological and social factors that influence the likelihood of autoagressive behavior

Patriotic Education as an Important Element in the Formation of the Value-Semantic Competence of Young People

The article is the author’s take on patriotic education as a factor in the formation of value-semantic competence of young people. Patriotic events based on the formation of a respectful attitude to the different opinion, history and culture of other peoples, makes possible the perception of ethnic and national identity, forms the values of a multinational Russian society. The article views a pedagogical experiment in a secondary school as a background for patriotic events that contribute to the education of students.В статье рассматривается патриотическое воспитание как фактор формирования ценностно-смысловой компетенции молодежи. Патриотические мероприятия, основанные на формировании уважительного отношения к иному мнению, истории и культуре других народов, способствуют осознанию своей этнической и национальной идентичности, формируют ценности многонационального российского общества. В статье показан педагогический эксперимент в средней школе как отправная точка для проведения патриотических мероприятий, способствующих воспитанию обучающихся

Optimization of indications for parasternal radiotherapy in patients with breast cancer

Detection of regional lymph nodes involvement is an extremely important step in the diagnosis and treatment of breast cancer. As with axillary lymph node metastases, parasternal lymph nodes metastases are an important prognostic factor. 1125 patients with breast cancer were under- went to thoracoscopicinternal mammary lymphadenectomy. Metastases were found in 204 of 1125 cases (18,3 %), representing 33,9 % of all cases of regional metastases (n = 601). Median overall survival in patients with internal mammary lymph nodes metastases who received radiation therapy and appropriate systemic treatment was 7,8 years, which is contrary to the earlier experience and is consistent with the results of the last years publications. We believe this excellent result is due to irradiation of the internal mammary nodes, and we believe that the thoracoscopic internal mammary lymphadenectomy should be a part of the diagnostic process in patients with breast cancer

Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia–Reperfusion

Ischemic brain stroke is one of the most serious and socially significant diseases. In addition to messenger RNAs (mRNAs), encoding protein, the study of regulatory RNAs in ischemic has exceptional importance for the development of new strategies for neuroprotection. Circular RNAs (circRNAs) have a closed structure, predominantly brain-specific expression, and remain highly promising targets of research. They can interact with microRNAs (miRNAs), diminish their activity and thereby inhibit miRNA-mediated repression of mRNA. Genome-wide RNA-Seq analysis of the subcortical structures of the rat brain containing an ischemic damage focus and penumbra area revealed 395 circRNAs changed their expression significantly at 24 h after transient middle cerebral artery occlusion model (tMCAO) conditions. Furthermore, functional annotation revealed their association with neuroactive signaling pathways. It was found that about a third of the differentially expressed circRNAs (DECs) originate from genes whose mRNA levels also changed at 24 h after tMCAO. The other DECs originate from genes encoding non-regulated mRNAs under tMCAO conditions. In addition, bioinformatic analysis predicted a circRNA–miRNA–mRNA network which was associated with the neurotransmission signaling regulation. Our results show that such circRNAs can persist as potential miRNA sponges for the protection of mRNAs of neurotransmitter genes. The results expanded our views about the neurotransmission regulation in the rat brain after ischemia–reperfusion with circRNA action