43 research outputs found
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ² Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΡΠΈΠΌΠ°Π½ΡΡΠ΅Π½Π°
ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡ
Π·Π°Π΄Π°Ρ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ Π²ΠΈΠ½ΠΈΠ»ΠΎΠ²ΡΡ
ΠΌΠΎΠ½ΠΎΠΌΠ΅ΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΈ ΡΠ²ΠΎΠΉΡΡΠ² ΠΎΠ±ΡΠ°Π·ΡΡΡΠΈΡ
ΡΡ ΠΌΠ°ΠΊΡΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ», Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ. Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ Π΄Π»Ρ ΠΈΠ½ΠΈΡΠΈΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠ΅ΠΉ ΡΠΎΡΡΠ° ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΠΎΠΉ ΡΠ΅ΠΏΠΈ ΡΡΠΏΠ΅ΡΠ½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ ΠΈΠ½ΠΈΡΠΈΠΈΡΡΡΡΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠ»Π°ΡΡΠΎΠ² ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΉ Π΄ΡΡΠ³ Ρ Π΄ΡΡΠ³ΠΎΠΌ.
Π Π°Π½Π΅Π΅ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π°Π·ΠΈΠ½ΠΈΠ»ΡΠ΅ΡΡΠΎΡΠ΅Π½Ρ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΎΠΌ Π±Π΅Π½Π·ΠΎΠΈΠ»Π° ΠΎΠ±ΡΠ°Π·ΡΡΡ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈΠ½ΠΈΡΠΈΠΈΡΡΡΡΠΈΠ΅ ΡΠΌΠ΅ΡΠΈ Π΄Π»Ρ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠΈΠ»ΠΌΠ΅ΡΠ°ΠΊΡΠΈΠ»Π°ΡΠ° Π² ΠΌΠ°ΡΡΠ΅. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π² ΠΈΠ½ΠΈΡΠΈΠΈΡΡΡΡΡΡ ΡΠΌΠ΅ΡΡ Π³Π΅ΡΠ°ΡΠΈΠ»ΡΠ΅ΡΡΠΎΡΠ΅Π½ΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΠΊΠΎΡΠΎΡΡΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΠΈΠ½ΠΈΡΠΈΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΡΠΌΠ΅Π½ΡΡΠΈΡΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ, ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ Π²ΡΡ
ΠΎΠ΄Ρ, ΠΏΠΎΠ»ΡΡΠΈΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΡΠ΅ΡΠ΅ΠΎΡΠ΅Π³ΡΠ»ΡΡΠ½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΡ, ΡΠΌΠ΅Π½ΡΡΠΈΡΡ Π³Π΅Π»Ρ-ΡΡΡΠ΅ΠΊΡ.
Π¦ΠΈΠΌΠ°Π½ΡΡΠ΅Π½ - ΡΡΡΡΠΊΡΡΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΎΠ³ ΡΠ΅ΡΡΠΎΡΠ΅Π½Π°, ΡΡΠΎ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°Π΅Ρ ΠΏΠΎΠ΄ΠΎΠ±ΠΈΠ΅ ΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ². ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π°Π·ΠΈΠ½ΠΈΠ»ΡΠΈΠΌΠ°Π½ΡΡΠ΅Π½ΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π²Π»ΠΈΡΡΡ Π½Π° ΡΡΠ°Π΄ΠΈΡ ΡΠΎΡΡΠ° ΡΠ΅ΠΏΠΈ, ΡΡΠΎ ΠΎΡΡΠ°ΠΆΠ°Π΅ΡΡΡ Π½Π° ΠΌΠΈΠΊΡΠΎΡΡΡΡΠΊΡΡΡΠ΅ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ»ΠΌΠ΅ΡΠ°ΠΊΡΠΈΠ»Π°ΡΠ°. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π΅ΡΠΎΡΡΠ½ΡΠΌ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΠΠ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π°Π·ΠΈΠ½ΠΈΠ»ΠΎΠ²ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
ΡΠΈΠΌΠ°Π½ΡΡΠ΅Π½Π° ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎ-ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΠΉ.
Π ΠΎΡΡΠ΅ΡΡ ΠΏΡΠΈΠ»Π°Π³Π°Π΅ΡΡΡ ΠΎΡΡΠΈΡΠΊ ΡΡΠ°ΡΡΠΈ Π² ΡΠ΅ΡΠ΅ΡΠΈΡΡΠ΅ΠΌΠΎΠΌ Π½Π°ΡΡΠ½ΠΎΠΌ ΠΆΡΡΠ½Π°Π»Π΅ ΠΏΠΎ ΡΠ΅ΠΌΠ΅ Π½Π°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΡΠ°Π±ΠΎΡΡ (ΠΡΠ»Π°ΠΌΠΎΠ² Π .Π., ΠΠ°Π·Π°ΡΠΎΠ²Π° Π‘.Π., Π£ΡΠ΅ΠΏΠΎΠ²Π° Π.Π., ΠΡΡΠΈΡ
ΠΈΠ½Π° Π.Π., Π§ΡΠΏΠ°Ρ
ΠΈΠ½ Π.Π. ΠΠ΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΡΠΈΠΌΠ°Π½ΡΡΠ΅Π½Π° Π² ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠΈΠ»ΠΌΠ΅ΡΠ°ΠΊΡΠΈΠ»Π°ΡΠ° // ΠΠΠ. β 2012. β 446. β Π‘. 637β641).ΠΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π£ΡΠ€Π£ Π½Π° 2013 Π³ΠΎΠ΄ (ΠΏ.1.2.1.5
Synthesis of chiral ferrocenylazines. Negishi cross-coupling or S N H reactions?
Preparation of new hetaryl-containing planar chiral ferrocene by a nucleophilic substitution of hydrogen in azines was performed using a lithium derivative of (S)-ferrocenyl-p-tolylsulfoxide as s nucleophilic reagent Β© 2013 Pleiades Publishing, Ltd
The Content of Teaching English as a Second Foreign Language
ΠΠ°Π½Π½Π°Ρ ΡΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°Π½ΠΈΡ Π°Π½Π³Π»ΠΈΠΉΡΠΊΠΎΠ³ΠΎ ΡΠ·ΡΠΊΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π²ΡΠΎΡΠΎΠ³ΠΎ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΈ ΠΎΠΏΠΎΡΠ΅ Π½Π° ΠΏΠ΅ΡΠ²ΡΠΉ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΠΉ ΡΠ·ΡΠΊ - Π½Π΅ΠΌΠ΅ΡΠΊΠΈΠΉ. Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ Π°Π½Π³Π»ΠΈΠΉΡΠΊΠΎΠΌΡ ΡΠ·ΡΠΊΡ ΠΊΠ°ΠΊ Π²ΡΠΎΡΠΎΠΌΡ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΠΎΠΌΡ Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΎΠΏΠΈΡΠ°ΡΡΡΡ Π½Π° ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Ρ ΡΡΠ°ΡΠΈΡ
ΡΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° ΠΏΠΎΠ»ΠΈΠ»ΠΈΠ½Π³Π²ΠΈΠ·ΠΌΠ° - ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ°ΡΡΡΡ Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ·ΡΠΊΠ° Π½Π° Π΄ΡΡΠ³ΠΎΠΉ. ΠΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ Ρ ΠΠ―1 Π½Π° ΠΠ―2. ΠΠ»Ρ ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ-ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄. Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ Π²ΡΠΎΡΠΎΠΌΡ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΠΎΠΌΡ ΡΠ·ΡΠΊΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΠ΅ΠΌΡ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡΡΠΈΠ΅ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ, ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π»ΠΎΠΆΠ½ΡΡ
Π·Π½Π°ΠΊΠΎΠ²ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ»ΠΎΠ²Π°ΠΌΠΈ.This article is devoted to the problem of teaching English as a second foreign language based on the first foreign language - German. The content of teaching English as a second foreign language is based on the creation of the mechanism of multilingualism in students - the ability to switch from one language to another. The main problem is the occurrence of the interference from FL1 to FL2. To overcome interference, it is necessary to use the comparative approach. This article proposes recommendations for optimizing the teaching of a second foreign language and teaching techniques that prevent interference, the creation of false sign relationships between words
Transition metal-free regioselective cross-coupling of azine N-oxides with cymantrenyl lithium
The facile CβC coupling reaction of activated forms of azaaromatics (azine-N-oxides) with cymantrenyl lithium, as a nucleophile, has first been carried out. It has been established that aromatization of intermediate adducts can be realized through either oxidative or eliminative pathways, depending on the structure of the starting azine N-oxide. In particular, the dihydroazinyl intermediates, bearing the additional N(4)-atom relative to the N-oxide group, proved to undergo aromatization through the eliminative pathway. The X-ray studies of 3,6-diphenyl-1,2,4-triazine-5-yl-cymantrene have revealed that it is crystallized in both orthorhombic and monoclinic forms. Β© 2018 Elsevier B.V
Oxidizing agents in metal-catalyzed and metal-free C-H functionalization of heteroarenes
Oxidative C-H functionalization represents a crucial method to make new C-C, C-X (X = heteroatom) bonds. An optimal selection of the oxidizing agent goes hand in hand with the insight into the reaction mechanism. This review covers recent advances in methods of direct oxidative C-H functionalization of azines and their derivatives with heteroaromatic nucleophiles. Also we review the data on application of inorganic and organic oxidants for implementation of these reactions. C-H functionalizations under electrochemical and photocatalytic oxidation conditions are included as well. Β© AUTHOR(S)Russian Foundation for Basic Research,Β Π Π€Π€Π: 19-29-08037,Β 20-43-660054We are grateful to the support from the Russian Foundation for Basic Research (Grants No. 20-43-660054 and 19-29-08037)
SYNTHESIS OF BIOLOGICAL ACTIVE AZINYLFERROCENE DERIVATIVES
As a rule, the presence of a lipophilic ferrocene unit in the drug structure modulates, and often enhances, their physiological activity. In this work the synthesis of vinyl-containing azinylferrocene derivatives was presented. It was found that previously obtained by direct C-H functionalization in (hetero)azinylferrocenes 1a-d (SN H reactions) undergo regioselective Friedel-Crafts acetylation to form 1, 1'-disubstituted 2a-d products with good yields, which are able to enter the Wittig reaction to the corresponding vinylferrocenes 3a-d.This work was supported by the Russian Foundation for Basic Research, project # 20-43-660054
Transition Metal-Free Regioselective Cross-Coupling of Azine N-Oxides With Cymantrenyl Lithium
We are grateful for financial supports from the Russian Science Foundation (Project β 14-13-01177), the Russian Foundation for Basic Research (Projects β 16-03-00958), and the Ministry of Education and Science of the Russian Federation (Project β 4.6351.2017/8.9)
AZINE-GRAPHENE-DYAD: SYNTHESIS AND PROPERTIES
This work was supported by the Russian Science Foundation, project β 22-13-00298
Synthesis of 1-azinyl-1'-isopropenylferrocenes
In this work we combine olefins and azines fragments on the ferrocene matrix by regioselective acetylation of azines followed by the Wittig reaction.This study was supported by the Russian Science Foundation (grant β 19-73-00243) and the Russian Foundation for Basic Research (Project β 20-43-660054)
Assessment of the psycho-emotional state of patients after COVID-19-associated pneumonia in relationship with laboratory indicators
The aim. To study peculiarities and association of psychological and laboratory indicators in patients with cardiovascular diseases (CVD) who underwent COVID-19 to clarify the factors affecting the possibility of developing delayed psychological and cardiovascular adverse events.Methods. The study enrolled 350 patients with COVID-19. Group 1 consisted of 92 patients without CVD, Group 2 β of 258 patients with CVD. Indicators of laboratory and psychological parameters were assessed according to the data of psychological questionnaire using GAD-7 (General Anxiety Disorder-7), PHQ-9 (Patient Health Questionnaire-9), PSS (Perceived Stress Scale) screening scales and SF-36. Parameters of complete blood count and biochemical blood tests were measured during hospitalization and three months after discharge from the monohospital.Results. After three months, in the general group of patients, signs of anxiety and depression were detected in more than 30 % of the examined patients, signs of stress β in 10.4 %. In the group with CVD, psycho-emotional disorders were identified in 1/4 of the patients, and severe stress β in 8 % of those included in the study. In addition, it was registered that the indicators of erythrocyte sedimentation rate, fibrinogen, high-sensitivity C-reactive protein (CRP), homocysteine and IL-6 remained at a higher level in the second group.Correlation analysis showed that the psychological component of health is interconnected with the level of neutrophils (p = 0.044) and fibrinogen (p = 0.050); the physical component of health is correlated with the level of erythrocytes (p = 0.030), hemoglobin (p = 0.015), CRP (p = 0.002), creatine phosphokinase (p = 0.036) and glucose (p = 0.017). Regression analysis revealed that in patients with CVD three months after hospitalization, an increased glucose index contributes to deterioration, and increased hematocrit and mean hemoglobin concentration improve the quality of life of patients.Conclusion. Laboratory markers that maintain the duration of a prolonged vascular reaction, violation of the rheological and metabolic properties of blood, determine the nature of the development of both psychological and cardiovascular complications