144 research outputs found
Developing a Supply Chain Subsystem to Manage the Process of Obstacle Elimination for the Innovative Development of Business Entities
Abstract- The negative trend protests in economic development reflect the lack of a systematic approach to innovative development and innovative process management. An important feature of innovative development is to ensure the elimination of obstacles to innovative development, to avoid threats and crisis situations in the activities of business entities. Thus, one of the urgent problems is the prediction of crisis phenomena, events, situations, the search for their elimination or leveling trends, the formation of preventive measures for their prevention and overcoming, the increase of strategic management effectiveness by innovation development in general. The purpose of the article is to develop a supply chain subsystem to manage the process of obstacle elimination for the innovative development of business entities. In order to achieve this goal, the following research methods were used: analysis and synthesis, schematic and graphic representation, modeling and forecasting, formal-logical method. The goal, the properties and the structure of process management supply chain subsystem to eliminate the obstacles to innovative development were substantiated. It was proved that the innovation strategy of economic entities should be subjected to certain adjustments in accordance with the dynamic changes in environmental conditions and the features of business entity functioning in it. They developed the model of innovative development process for an entrepreneurial entity using the removal of obstacles to innovative development, based on creativity, leadership competence, the delegation of managerial powers, the coordination of activities and cooperation. The main characteristics and the obstacles of each stage of the model are substantiated in order to develop appropriate programs and activities for their overcoming. The scientific novelty of the research is the development of the classification set of phenomena, events and situations. These elements create the obstacles to the innovative development of business entities, as well as the ways to overcome the obstacles that threaten innovative development, which contributes to the improvement of the decision-making process in the field of an innovative strategy development for business entities. Keywords: innovative development, supply chain management subsystem, obstacle elimination, business entities, strategic managemen
Prospects of Spin Catalysis on Spin-Polarized Graphene Heterostructures
Extreme points on potential energy surfaces of Ni adatom on free-standing graphene and top:fcc and hcp:fcc graphene/
Ni(111) heterostructures in different spin states were studied using periodic boundary conditions density functional theory
approach. It was found that the spin states of the substrates strongly influence the energy of the Ni adatom extreme points
on potential energy surface by decreasing (top:fcc heterostructure) or increasing (hcp:fcc heterostructure) the total
energies of Z1, Z1 , and Z2 Ni adatom coordinations on graphene. This phenomenon offers unique possibilities to control
the potential energy surfaces of transition metal adatoms and promote surface chemical reactions using induced spin
polarization of graphene substrates
The theoretical DFT study of electronic structure of thin Si/SiO2 quantum nanodots and nanowires
The atomic and electronic structure of a set of proposed thin (1.6 nm in
diameter) silicon/silica quantum nanodots and nanowires with narrow interface,
as well as parent metastable silicon structures (1.2 nm in diameter), was
studied in cluster and PBC approaches using B3LYP/6-31G* and PW PP LDA
approximations. The total density of states (TDOS) of the smallest
quasispherical silicon quantum dot (Si85) corresponds well to the TDOS of the
bulk silicon. The elongated silicon nanodots and 1D nanowires demonstrate the
metallic nature of the electronic structure. The surface oxidized layer opens
the bandgap in the TDOS of the Si/SiO2 species. The top of the valence band and
the bottom of conductivity band of the particles are formed by the silicon core
derived states. The energy width of the bandgap is determined by the length of
the Si/SiO2 clusters and demonstrates inverse dependence upon the size of the
nanostructures. The theoretical data describes the size confinement effect in
photoluminescence spectra of the silica embedded nanocrystalline silicon with
high accuracy.Comment: 22 pages, 5 figures, 1 tabl
Mechanism of dicarbonyl(2,4-pentanedionato)iridium(I) decomposition on iron surface and in gas phase: Complex experimental and theoretical study
The mechanism of thermal destruction of Ir(acac)(CO)2 as one of the most important MOCVD precursors for Ir coatings deposition was proposed on the footing of the in situ mass spectrometry analysis and quantum chemical modeling. Calculated structural parameters and vibrational spectra of Ir(acac)(CO)2 molecule were found to be in a fairly good agreement with the experimental data. Ir(acac)(CO)2 was found to unlikely decompose in the gaseous phase while its adsorption onto the iron surface leads to major structural distortions easing the bond cleavage, molecule decomposition with subsequent formation of iridium films
A PERSONALIDADE CIVIL DOS NASCITUROS E OS SEUS REFLEXOS JURΓDICO-PROCESSUAIS
Sempre foi acirrada a discussão sobre a personalidade e capacidade civil dos nascituros. Reconhecer-lhes a titularidade de direitos fez forçosa a anÑlise sobre a capacidade de ser parte em um processo. O que se concluiu é que, mesmo prevalecendo no Brasil a Teoria Natalista, a Teoria da Personalidade Condicional se apresenta mais acertada, tendo em vista a necessidade de o Código Civil ser interpretado sistemÑtica e teleologicamente com o texto constitucional, de modo que a protetividade das normas de direitos humanos estendam seus efeitos também a quem se encontra no ventre materno
Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination
Immunization against smallpox may be attended by serious complications. The premises for the differences in postvaccinal reaction intensity are underexplored. In this paper presented is the review of peculiarities of postvaccinal manifestations in members of the Russian population primarily immunized against smallpox as compared to the revaccinated ones. Examined has been the cohort of 217 people, of whom 82 are vaccinated initially, and 135 - repeatedly within the period from 2000 to 2013. Average age of the vaccinated is 40.0 years (ranged 20 to 40). Studied has been severity of vaccine-challenged condition and cutaneous inflammatory vaccinal elements. In case of initial vaccination medium severity has been observed 2.1 times oftener than low one. In case of revaccination - low level of severity has been registered 17.7 times more frequently than the medium one. Hyperemia zone is 2.2 times greater as regards primary vaccination compared to revaccination, zone of induration - 1.9 times. The diameter of the sore is 1.3 and its shedding time is 1.4 times greater and longer, respectively. Thus, initial vaccination follows more severe course and is attended by expressed response in comparison to booster one
ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΡΠ΅ΡΡΡΠΈΠ°ΠΊΡΠΎΠ½Π° Ρ Mg(II): ΡΠΈΠ½ΡΠ΅Π·, ΡΡΡΡΠΊΡΡΡΠ°, ΡΠΏΠ΅ΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°
Magnesium complex of ceftriaxone was obtained and characterized by atomic-emission and elemental analysis, TGA, FTIR and Raman spectroscopy, Xβray diffraction and density functional theory calculations. Ceftriaxone was coordinated to the magnesium ion by the oxygen of the triazine cycle in the 6th position, the nitrogen of the amine group of the thiazole ring, and oxygen atoms of the lactam carbonyl and carboxylate groups. The disodium salt of ceftriaxone and magnesium complex were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaΠΠΎΠ»ΡΡΠ΅Π½ ΠΈ ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½ ΠΌΠ°Π³Π½ΠΈΠ΅Π²ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΡΠ΅ΡΡΡΠΈΠ°ΠΊΡΠΎΠ½Π° ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ
Π°ΡΠΎΠΌΠ½ΠΎ-ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ
ΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·ΠΎΠ², Π’ΠΠ, ΠΠ- ΠΈ ΠΠ βΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, Π Π€Π ΠΈ ΡΠ°ΡΡΠ΅ΡΠΎΠ²
ΡΠ΅ΠΎΡΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»Π° ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ. Π¦Π΅ΡΡΡΠΈΠ°ΠΊΡΠΎΠ½ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΡΠ΅ΡΡΡ ΠΊ ΠΈΠΎΠ½Ρ ΠΌΠ°Π³Π½ΠΈΡ ΡΠ΅ΡΠ΅Π· ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄
ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° Π² ΡΠ΅ΡΡΠΎΠΌ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ, Π°Π·ΠΎΡ Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏΡ ΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° ΠΈ Π°ΡΠΎΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°
ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»ΡΠ½ΠΎΠΉ ΠΈ Π»Π°ΠΊΡΠ°ΠΌΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏ. ΠΠΈΠ½Π°ΡΡΠΈΠ΅Π²Π°Ρ ΡΠΎΠ»Ρ ΡΠ΅ΡΡΡΠΈΠ°ΠΊΡΠΎΠ½Π° ΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΌΠ°Π³Π½ΠΈΡ Π±ΡΠ»ΠΈ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π½Π° Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Staphylococcus aureus, Escherichia
coli ΠΈ Pseudomonas aeruginos
The influence of size effect on the electronic and elastic properties of diamond films with nanometer thickness
The atomic structure and physical properties of few-layered oriented
diamond nanocrystals (diamanes), covered by hydrogen atoms from both sides are
studied using electronic band structure calculations. It was shown that energy
stability linear increases upon increasing of the thickness of proposed
structures. All 2D carbon films display direct dielectric band gaps with
nonlinear quantum confinement response upon the thickness. Elastic properties
of diamanes reveal complex dependence upon increasing of the number of
layers. All theoretical results were compared with available experimental data.Comment: 16 pages, 5 figures, 3 table
A single blind, placebo-controlled randomized study of the safety, reactogenicity and immunogenicity of the βEpiVacCoronaβ Vaccine for the prevention of COVID-19, in volunteers aged 18β60 years (phase IβII)
Vaccination of the population is one of the most effective countermeasures in responding to the pandemic caused by novel coronavirus infection. Therefore, scientists all over the world have been working to develop effective and safe vaccines. We have developed a synthetic peptide vaccine, EpiVacCorona, against novel SARS-CoV-2 coronavirus, which is a suspension for intramuscular administration containing a composition of chemically synthesized peptide immunogens of the S protein of SARS-CoV-2 coronavirus conjugated to a carrier protein and adsorbed on aluminum hydroxide. Phase IβII clinical trials of the vaccine have started that consist of two stages: Stage 1 is an open study of the safety, reactogenicity, and immunological activity of the vaccine with the involvement of 14 volunteers aged 18β30 years; Stage 2 is a single blind, comparative, randomized placebo-controlled study with the involvement of 86 volunteers. The study involved volunteers aged 18β60 years; the vaccine was injected intramuscularly twice, spaced 21 days apart between injections. All local reactions in response to vaccine administration were mild, such as a short-term pain at the injection site. There were no signs of development of local or systemic adverse reactions. The two-dose vaccination scheme induced the production of antibodies, specific to the antigens that make up the vaccine, in 100% of the volunteers. Seroconversion with a neutralizing antibody titer β₯ 1:20 was reported in 100% of the volunteers 21 days following the second immunization dose. No seroconversion was reported in the groups of volunteers vaccinated with a placebo. The peptide-based EpiVacCorona Vaccine has low reactogenicity and is a safe, immunogenic product. Clinical Trials Identifier: NCT04527575
Phase I clinical trials of safety and immunogenicity of live cultural influenza vaccine vector-flu
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