The character of fracture of iron based thermal coating during fretting

The character of destruction of thermal coatings during fretting has been investigated. An iron based plasma coating has been tested with oscillation amplitude from 30 to 200 microns. The tests were conducted in air. It has been determined that the main factor influencing the rate of the wear of the coating during fretting corrosion is the size of the coating area involved into the wear process. The coating exhibits high wear resistance when the amplitude of the oscillation is commensurate with the size of the sprayed particles. During destruction of the coating the leading role belongs to fatigue-oxidation processes. The wear of the coating acquires a catastrophic character when coating macro defects - pores and interlayer boundaries - are involved into the wear process

The character of fracture of iron based thermal coating during fretting

The character of destruction of thermal coatings during fretting has been investigated. An iron based plasma coating has been tested with oscillation amplitude from 30 to 200 microns. The tests were conducted in air. It has been determined that the main factor influencing the rate of the wear of the coating during fretting corrosion is the size of the coating area involved into the wear process. The coating exhibits high wear resistance when the amplitude of the oscillation is commensurate with the size of the sprayed particles. During destruction of the coating the leading role belongs to fatigue-oxidation processes. The wear of the coating acquires a catastrophic character when coating macro defects - pores and interlayer boundaries - are involved into the wear process

Nonel approaches in the field of gastric cancer surgical treatment

The aim of the study: to estimate the impact of different cellular phenotype of gastric tumors on the survival of patients treated according to standard protocols. Object and methods of research.The work presents the results of a study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology and surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (GC) in the period 2007-2013. The average age of patients was 60.88 ± 10.5 years, men - 180, women - 41. Of the total number of operated, 143 patients underwent surgery in the amount of gastrectomy, 78 - subtotal distal resection. Results. All patients included in the study underwent radical surgery. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained results are monitored for the presence/absence of clinical parallels and mathematical correlations. It was concluded that some combinations of immunohistochemical (IHC) markers were effective in separating groups of patients with different biology of gastric cancer. Conclusions. Performing more advanced operations (including the use of D2 lymph dissections) is the most effective option for surgical treatment of microsatellite-unstable and Epstein-Barr virus-associated gastric cancer

Choroidal neovascularization activity and structure by optical coherence tomography angiography in age related macular degeneration

Background. In economically developed countries, age-related macular degeneration (AMD) is the leading cause of visual disability among the population of the older age group. The main criterion for the anti-VEGF treatment of neovascular AMD is the activity of choroidal neovascularization (CNV), which is determined by its confi guration. The search for optimal criteria for quantifying the state of the macular region in order to decide on the appointment of anti-VEGF therapy continues.Aim: improving the effi ciency of diagnosis and treatment of AMD based on the assessment of the configuration of vascular system on the “Key to Diagnosis II” platform.Material and methods. The study included 341 patients: 64 % (218 patients, 267 eyes) with non-neovascular AMD, 36 % (123 patients, 174 eyes) – with neovascular AMD. 56 patients (58 eyes) had active type I CNV. Group 1A – active CNV before treatment (9 patients, 9 eyes), group 1B – non-active CNV after treatment with antiVEGF (9 patients, 9 eyes); control group – 10 patients (10 eyes) without AMD. Analysis of OCT-angio images of choriocapillaries included the isolation of CNV, its area, fractal dimension (Df) and the complexity of the vascular system (CVS) counting.Results. Group 1A: Df – 1.5871 ± 0.05, CVS – 2.29 ± 0.29, area – 11734 ± 4866; group 1B: Df – 1.6462 ± 0.08, CVS – 1.65 ± 0.18, area – 6797 ± 3818; control: Df – 1.9167 ± 0.06, CVS – 1, area – 0. Significant differences were found for CVS (p = 0.0003). Df correlates with the CNV area (p = 0.7) and is probably an unreliable parameter due to incomplete visualization of active CNV.Conclusions. CVS is a quantitative biomarker for determining the activity of type 1 CNV in patients with AMD and can serve as a parameter for convolutional neural networks training for automated analysis of OCT angiography images based on the “Key to Diagnosis II” platfor

Investigation of high-energy external influences on structural heredity of the Ti-Nb alloy

The effects of high-energy external influences on structural heredity of Ti-Nb alloy is investigated in this paper. By the methods of XRD, SEM, EDX and optical microscopy it was founded that thermal treatment and severe plastic deformation lead to the phase transformations in the alloy, the dendritic segregation occurs and retains in the alloy under external influences

Available drugs during of military state: social-economic strategies of functioning reimbursumen’t system

The Russian aggresion against Ukraine became a new reality in the XXI century and definitely shook the whole World. New realities are forcing all spheres of science and practice to work harder and develop, that is why philosophers of law are tended to call war “the driving force of progress”. Our modern life in the condition of war proves, that the technical and scientific progress as it is, is created and developed on thousands and millions of destroyed human lives. But, in order to make a warring society to move successfully forward, save as many innocent lives as possible and meet basic needs of a particularly vulnerable polutation, it is not only army, which is supposed to work for 100%, but also “home front workers” has to try harder. The current war has dimished an understanding of difference between quintiles of population, especially, if we are taking into account differences between beneficiaries of the Affordable Medicines Program (AM). At the beginning of the War, all beneficiaries of the AM, despite of level of their well-being had to suffer equally because of the short-term period of medicines’ shortage due to destroyed infrastructure of cities and regions. They were afraid that those highly necessary medicines would not return to the pharmacies neither in the sphere of the AM, nor even for normal sale. Because of the aforementioned force-majeure, most of people were not even assured that their basic needs will be met, especially were worried those ones, who have been active users of the AM for a long period of time. However, despite of the aforementioned destruction of the insfrastrucutre, the commons fears and dangers of war, the AM has not stopped working. On the contrary, it has become even more successful and progressive. The need to react quickly to the circumstances that took place, forced to achieve long-term plans of the AM creators in a very short time. Thus, the pilot program has finally fit into the general outline of the life support and health care system of Ukraine and became perhaps the most progressive in the whole Europe. But, nevertheless, the progress is definitely not standing still, the situation remains critical, the humanitarian catastrophe is becoming more and more real today, and, thus, the AM opens new promising ways of development for the coming month and years. In fact, our study was devoted to the analysis of the changes that took place since February 24, 2022, as well as promising directions for the development of AM, which are mostly dictated by the newly created humaniatrian crises in the current article.Новою реалією ХХІ століття стала загарбницька війна Росії проти України, яка без сумніву сколихнула цілий світ. Нові реалії життя змушують всі сфери науки і практики працювати у посиленому режимі та розвиватись, саме тому філософи права називають війну “рушійною силою прогресу”. Сучасне життя доводить, що технічний і науковий прогрес, як виявилось, створюється і розвивається на тисячах і мільйонах зруйнованих людських життів. Але, задля того, щоб суспільство країни, що воює, змогло рухатись далі, змогло врятувати якумога більше безвинних життів та забезпечувати базові потреби особливо вразливого контингенту населення, не тільки армія, але й “герої тилу”, тобто медики і вся система охорони здоров’я мають працювати на 100%, як це власне і відбувається зараз. Війна знизила важливість понять “квінтилі населення”, особливо якщо йдеться про прямих бенефіціарів програми “Доступні ліки”, адже серед них всі, незалежно від особистого та фінансового благополуччя, були піддані необхідності страждати від першострокової нестачі ліків, які забезпечувались програмою; були підвергнуті страху, що ці ліки не повернуться не тільки в рамках програми Доступні ліки (ДЛ), але і в принципі будуть недоступні через знищену інфраструктуру багатьох міст, а отже здійснився такий force majeure, при якому жодна людина не могла бути впевнена у власному забезпеченні навіть базових потреб, і особливо ті, хто протягом тривалого часу вже був активним користувачем ДЛ. Тим не менш, не дивлячись на вищезгадану зруйновану інфраструктуру, загальні страх і небезпеку, які приносить із собою війна, програма ДЛ не припинила свою роботу, навпаки, стала навіть більш прогресивною і успішною. Необхідність стрімко реагувати на обставини, які мали місце з погляду на війну, змусили досягнути довготривалі плани творців ДЛ за дуже короткий термін. Таким чином, пілотна програма остаточно вписалась в загальну канву системи життєзабезпечення та охорони здоров’я України і стали чи не найбільш прогресивною в цілій Європі. Але, тим не менш, прогрес безумовно не стоїть на місці, ситуація залишається критичною, гуманітарна катастрофа стає все більш реальною на сьогоднішній день, а отже ДЛ відкриває нові перспективні шляхи розвитку на найближчі місяці і роки. Власне аналізові змін, які мали місце, починаючи від 24-го лютого 2022 року, а також перспективним напрямкам розвитку ДЛ, які здебільшого продиктовані новоствореними гуманітраними кризами населення нашої країни, які мали місце через війну, і було присвячено наше дослідження, результати якого будуть освітлені у нинішній статті

Phase Composition and Microstructure of Ti-Nb Alloy Produced by Selective Laser Melting

The phase composition and microstructure of Ti-Nb alloy produced from composite titanium and niobium powder by selective laser melting (SLM) was studied. Produced monolayered Ti-Nb alloy enhanced the formation of fine-grained and medium-grained zones with homogeneous element composition of 36-38% Nb mass interval. Alloy phase composition responded to [beta]-alloy substrate phase (grain size was 5-7 pm) and non-equilibrium martensite [alpha]"- phase (grain size was 0.1-0.7 [mu]m). [alpha]"-phase grains were found along [beta]-phase grain boundaries and inside grains, including decreased niobium content. Alloy microhardness varied within 4200-5500 MPa

Peculiarities of electronic heat capacity of thulium cuprates in pseudogap state

Precise calorimetric measurements have been carried out in the 7 - 300 K temperature range on two ceramic samples of thulium 123 cuprates TmBa2Cu3O6.92 and TmBa2Cu3O6.70. The temperature dependence of the heat capacity was analyzed in the region where the pseudogap state (PGS) takes place. The lattice contribution was subtracted from the experimental data. The PGS component has been obtained by comparing electronic heat capacities of two investigated samples because the PGS contribution for the 6.92 sample is negligible. The anomalous behavior of the electronic heat capacity near the temperature boundary of PGS was found. It is supposed that this anomaly is due to peculiarities in N(E) function where N is the density of electronic states and E is the energy of carriers of charge.Comment: 12 pages, 3 Postscript figure

РАЗРАБОТКА ПРИКЛАДНОГО ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ НА ПЛАТФОРМЕ.NET С ПРИМЕНЕНИЕМ АСПЕКТНО-ОРИЕНТИРОВАННОГО ПРОГРАММИРОВАНИЯ

The authors’ aim is to develop application software for building stable distributed applications. The objectives are to identify main issues in building distributed applications and to suggest effective methods to solve these problems. The proposed solution can be used in building distributed applications and it will allow to significantly reduce the time spent on supporting infrastructure code in such applications.Целью данной статьи является разработка модели для построения устойчивых распределенных приложений. Задачами данной статьи являются выявление основных проблем при разработке распределенных приложений и предложение методов по их решению. Предлагаемое решение может быть применено в распределенных системах и позволит существенно снизить время на поддержку инфраструктурного кода