On ‘Age-old Russian Backwardness’

The article was submitted on 25.09.2017.This article considers the applicability of the concept of backwardness which was one of the basic concepts of both Russian and Western historiography of prerevolutionary Russia until the late 20th century and resulted from the constant comparison of Russia with the conventional ‘West’. On the one hand, modern historiography is characterised by a ‘normalisation’ of Russian history, i.e. attempts to prove that, considered generally, Russian historical development was identical to that of Western Europe, and, on the other hand, complete refusal to compare Russia and the West due to Russia having an altogether different and unique model of historical development. However, both of these trends contradict the worldview Russians had between the 18th and early 20th centuries. The author characterises both trends as dead ends as the concept of Russia’s ‘normality’ makes it impossible to explain the events of the imperial era, while the other approach deprives a historian of one of the major research tools in studying the past. It results in an intellectual trap, and the author suggests that to solve this problem, scholars should create a new language of historical research and accumulate empirical data that would create a more complex and multidimensional image of the past.Статья посвящена обсуждению применимости концепта отсталости, вплоть до конца XX в. являвшегося одним из базовых концептов отечественной и зарубежной историографии дореволюционной России и сформировавшегося на основе постоянного сравнения России и условного «Запада». В современной историографии наблюдаются как попытки «нормализации» русской истории, стремление доказать, что в основных своих чертах историческое развитие России было идентично развитию стран Западной Европы, так и полный отказ от сравнений России с Западом в силу признания инаковости русской модели исторического развития. Однако это входит в противоречие с той картиной мира, которая существовала в сознании русских людей XVIII – начала XX в. и которые были собственно творцами истории страны. Обе эти позиции представляются тупиковыми, поскольку концепт нормальности исключает возможность объяснить многие события имперского периода, а отказ от сравнения лишает историка одного из важнейших инструментов познания прошлого. Таким образом, возникает своего рода интеллектуальная ловушка, выход из которой автор видит в выработке нового научного языка, а также в накоплении эмпирического материала, создающего более сложный и многомерный образ прошлого.Статья подготовлена в рамках проекта «Законодательный процесс, социальная мобильность и социальные практики в российском и западноевропейском обществе раннего Нового времени» программы фундаментальных исследований Национального исследовательского университета – Высшей школы экономики 2017 г

Evaluation of Measurement Performance in Averaging Quantization System with Noise

Statistical description of quantization process is common in the theory of quantization. For the case of nonsubtractive dither theoretical analyses of the dithered quantizer have been confronted with experimental results. As a quantization system one-chip microcomputer with the analog-to-digital converter on a chip has been used. Generally valid criteria for dithered system performance have been practically applied for Gaussian dither. Interaction of natural noise present in the signal with an added Gaussian noise of several different disperses and influence of differential nonlinearity of the converter has been observed

Fate of Sessile Droplet Chemical Agents in Environmental Substrates in the Presence of Physiochemical Processes

A general-purpose multi-phase and multi-component computer model capable of solving the complex problems encountered in the agent substrate interaction is developed. The model solves the transient and time-accurate mass and momentum governing equations in a three dimensional space. The provisions for considering all the inter-phase activities (solidification, evaporation, condensation, etc.) are included in the model. The chemical reactions among all phases are allowed and the products of the existing chemical reactions in all three phases are possible. The impact of chemical reaction products on the transport properties in porous media such as porosity, capillary pressure, and permeability is considered. Numerous validations for simulants, agents, and pesticides with laboratory and open air data are presented. Results for chemical reactions in the presence of pre-existing water in porous materials such as moisture, or separated agent and water droplets on porous substrates are presented. The model will greatly enhance the capabilities in predicting the level of threat after any chemical such as Toxic Industrial Chemicals (TICs) and Toxic Industrial Materials (TIMs) release on environmental substrates. The model’s generality makes it suitable for both defense and pharmaceutical applications

The Analog of Arginine-Vasopressin (6-9) Fragment, Ac-D-SPRG, Exhibits Antidepressant Action in Rats in Case of Intranasal Injection

The antidepressant properties of newly synthesized analog of arginine-vasopressin fragment analog, Ac-D-SPRG, were tested using Porsolt’s swimming test on white rats. It was demonstrated that this substance when injected intranasally decreases the depression in comparison with the control group

On the dispersionless Kadomtsev-Petviashvili equation in n+1 dimensions: exact solutions, the Cauchy problem for small initial data and wave breaking

We study the (n+1)-dimensional generalization of the dispersionless Kadomtsev-Petviashvili (dKP) equation, a universal equation describing the propagation of weakly nonlinear, quasi one dimensional waves in n+1 dimensions, and arising in several physical contexts, like acoustics, plasma physics and hydrodynamics. For n=2, this equation is integrable, and it has been recently shown to be a prototype model equation in the description of the two dimensional wave breaking of localized initial data. We construct an exact solution of the n+1 dimensional model containing an arbitrary function of one variable, corresponding to its parabolic invariance, describing waves, constant on their paraboloidal wave front, breaking simultaneously in all points of it. Then we use such solution to build a uniform approximation of the solution of the Cauchy problem, for small and localized initial data, showing that such a small and localized initial data evolving according to the (n+1)-dimensional dKP equation break, in the long time regime, if and only if n=1,2,3; i.e., in physical space. Such a wave breaking takes place, generically, in a point of the paraboloidal wave front, and the analytic aspects of it are given explicitly in terms of the small initial data.Comment: 20 pages, 10 figures, few formulas adde

Non-invasive optical method for evaluating the oxygen status in breast neoplasms

The paper presents the results from a study of the breast oxygen status by diffuse optical tomography (DOT). Detection of breast tissue at wavelengths of 684, 794, and 850 nm could provide information on the distribution of basic tissue chromophores: oxygenized and deoxygenized hemoglobin. Normal breast tissue was characterized by the even distribution of these compounds and stabilization of their level. In breast cancer, the distribution of oxy- and deoxyhemoglobin was noted for uneven distribution and blood oxygen saturation was lower in the projection of a tumor nodule. The blood oxygen saturation data obtained by DOT demonstrate physiological differ- ences between normal and tumor tissues in different tumor areas

Predictors, type, and impact of bleeding on the net clinical benefit of long-term ticagrelor in stable patients with prior myocardial infarction

BACKGROUND: Ticagrelor reduces ischemic risk but increases bleeding in patients with prior myocardial infarction. Identification of patients at lower bleeding risk is important in selecting patients who are likely to derive more favorable outcomes versus risk from this strategy. METHODS AND RESULTS: PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin—Thrombolysis in Myocardial Infarction 54) randomized 21 162 patients with prior myocardial infarction in a 1:1:1 fashion to ticagrelor 60 mg or 90 mg twice daily or placebo, with ticagrelor 60 mg approved for long-term use. TIMI major or minor bleeding was the primary end point for this analysis. Causes of bleeding were categorized by site and etiology, and independent predictors were identified. At 3 years, ticagrelor 60 mg increased the rate of TIMI major or minor bleeding by 2.0% versus placebo (1.4% placebo versus 3.4% ticagrelor). The bleeding excess was driven primarily by spontaneous gastrointestinal bleeds. A history of spontaneous bleeding requiring hospitalization and the presence of anemia were independent predictors of bleeding but not of ischemic risk. Patients with at least 1 risk predictor had 3-fold higher rates of bleeding with ticagre-lor 60 mg versus those who had neither (absolute risk increase, 4.4% versus 1.5%; P=0.01). Patients with neither predictor had a more favorable benefit profile with ticagrelor 60 mg versus placebo including lower mortality (hazard ratio, 0.79; 95% CI, 0.65–0.96; P interaction = 0.03). CONCLUSIONS: In patients with prior myocardial infarction, bleeding with ticagrelor 60 mg twice daily is predominantly spontaneous gastrointestinal. A history of spontaneous bleeding requiring hospitalization or the presence of anemia identifies patients at higher risk of bleeding, and the absence of either identifies patients likely to have a more favorable net benefit with ticagrelor

Lipoprotein(a) plasma levels, bone mineral density and risk of hip fracture: a post hoc analysis of the Women\u27s Health Initiative, USA

OBJECTIVES: Elevated Lipoprotein(a) (Lp[a]) is a well-known risk factor for cardiovascular disease. However, its roles in bone metabolism and fracture risk are unclear. We therefore investigated whether plasma Lp(a) levels were associated with bone mineral density (BMD) and incident hip fractures in a large cohort of postmenopausal women. DESIGN: Post hoc analysis of data from the Women\u27s Health Initiative (WHI), USA. SETTING: 40 clinical centres in the USA. PARTICIPANTS: The current analytical cohort consisted of 9698 white, postmenopausal women enrolled in the WHI, a national prospective study investigating determinants of chronic diseases including heart disease, breast and colorectal cancers and osteoporotic fractures among postmenopausal women. Recruitment for WHI took place from 1 October 1993 to 31 December 1998. EXPOSURES: Plasma Lp(a) levels were measured at baseline. OUTCOME MEASURES: Incident hip fractures were ascertained annually and confirmed by medical records with follow-up through 29 August 2014. BMD at the femoral neck was measured by dual X-ray absorptiometry in a subset of participants at baseline. STATISTICAL ANALYSES: Cox proportional hazards and logistic regression models were used to evaluate associations of quartiles of plasma Lp(a) levels with hip fracture events and hip BMD T-score, respectively. RESULTS: During a mean follow-up of 13.8 years, 454 incident cases of hip fracture were observed. In analyses adjusting for confounding variables including age, body mass index, history of hysterectomy, smoking, physical activity, diabetes mellitus, general health status, cardiovascular disease, use of menopausal hormone therapy, use of bisphosphonates, calcitonin or selective-oestrogen receptor modulators, baseline dietary and supplemental calcium and vitamin D intake and history of fracture, no significant association of plasma Lp(a) levels with low hip BMD T-score or hip fracture risk was detected. CONCLUSIONS: These findings suggest that plasma Lp(a) levels are not related to hip BMD T-score or hip fracture events in postmenopausal women. TRIAL REGISTRATION NUMBER: NCT00000611; Post-results