Organizational-Economic Directions of the Effective Use of Supply Chain Strategy in Rural Territories of Kazakhstan

The article discusses the issues of creating a solid fodder basis for keeping livestock in the personal subsidiary farm of the rural population based on supply chain strategy. The analysis of the use of pastures on fixed lands of settlements has been conducted based on the example of five regions of Kazakhstan and a number of rural districts. A huge shortage of pastures in the territories of rural settlements and a discrepancy between the livestock population of the households and the level of their feed supply have been revealed. The assessment of the current regulatory and legislative framework and prospects for the organizational and economic use of these territories is presented. The necessity of regulating the use of pastures through the application of standards for limiting the livestock management per one household, the system of pasture rotation and radical improvement of pastures, allocation of additional areas at the expense of reserve lands, development of cooperation have been justified

Study on physical and chemical properties of steel 60С2ХА on a retractable roller conveyor

These days, ensuring the high quality of thin products (0,6 – 2,0 mm) is the most promising direction for the development of hot-rolled strip production. Hot-rolled strips can be used in place of a more expensive cold-rolled strip. The effect of cooling modes on quality of hot-rolled metal was observed heating at different temperature, the degree of deformation was observed after cooling by water-air mixture. It was observed that the micro hardness of the samples decreases and the amount of structurally free ferrite increases by decreasing the cooling time and increasing the temperature

Study of stress-strain state billets when rolling in a continuous mill of hot-rolled thin stripes using MSC super forge

The article proposes a new design of a continuous mill. To study the stress-strain state during rolling of thin slabs on the proposed mill, a three-dimensional geometric and simulation model of the rolling process was developed using MSC SUPER FORGE. Based on the obtained results of numerical modeling, the distributions of equivalent strains in a thin slab when rolling in 1 mill stand, the distribution of equivalent stresses in a thin slab when rolling in 1 mill stand, the distribution of the temperature field in a thin slab when rolling in 1 mill stand

Study on stress-strain state and deformations occurring in existing roller tables

The design of a new diverting roller table is presented, containing continuous series of sections with diverting rollers. Using the program product of finite element analysis of Autodesk Inventor, the stress-strain state rollers of the new outrigger roller table is calculated. It is proved that the maximum concentrations of stresses and deformations are observed in barrels and necks of rollers a new outrigger roller table. At the same time, the value of these indices is much smaller in comparison with the values of stresses and deformations occurring in existing roller tables

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM

Внутрикостная химиотерапия в лечении инвазивного рака мочевого пузыря

Neoadjuvant chemotherapy (CT) with cisplatin administered intraosseously into the pubic bone in patients with invasive bladder carcinoma (Т2—4N0M0) was most effective in patients with circular involvement of the bladder neck, even in large tumors of 5—7 cm. Out of 4 patients with this site of a tumor, full regression without further treatment was achieved in one patient, transurethral resection was performed in 3 patients with 75% tumor regression. In multiple bladder tumor lesions involving the bladder neck, the degree of regression was not greater than 40%. The therapeutic efficiency of intraosseous CT with cisplatin was 54% with acceptable toxicity.