6,796 research outputs found
High-throughput in-situ characterization and modelling of precipitation kinetics in compositionally graded alloys
The development of new engineering alloy chemistries is a time consuming and
iterative process. A necessary step is characterization of the
nano/microstructure to provide a link between the processing and properties of
each alloy chemistry considered. One approach to accelerate the identification
of optimal chemistries is to use samples containing a gradient in composition,
ie. combinatorial samples, and to investigate many different chemistries at the
same time. However, for engineering alloys, the final properties depend not
only on chemistry but also on the path of microstructure development which
necessitates characterization of microstructure evolution for each chemistry.
In this contribution we demonstrate an approach that allows for the in-situ,
nanoscale characterization of the precipitate structures in alloys, as a
function of aging time, in combinatorial samples containing a composition
gradient. The approach uses small angle x-ray scattering (SAXS) at a
synchrotron beamline. The Cu-Co system is used for the proof-of-concept and the
combinatorial samples prepared contain a gradient in Co from 0% to 2%. These
samples are aged at temperatures between 450{\textdegree}C and
550{\textdegree}C and the precipitate structures (precipitate size, volume
fraction and number density) all along the composition gradient are
simultaneously monitored as a function of time. This large dataset is used to
test the applicability and robustness of a conventional class model for
precipitation that considers concurrent nucleation, growth and coarsening and
the ability of the model to describe such a large dataset.Comment: Published in Acta Materiali
The Little Book of Public Space and the Internet of Things
Our public spaces are changing, they are at the forefront of a technological revolution yet this is a revolution that often remains hidden from sight. Sensors are being installed and the ability to interact with objects in our spaces – from projects such as the PETRAS Talking Trees through to conversations with Lamp Posts or data interactions with local wildlife is changing our interactions both in and with these places and spaces.
This Little Book explores safety and security and moves onto maintenance. We then look at some of the issues affecting people and explore health, community building and culture while exploring the use of public space for play. After this, we explore conservation and culture, transport and signage, accessibility and then, finally, we discuss future trends
Density hardening plasticity and mechanical aging of silica glass under pressure: A Raman spectroscopic study
In addition of a flow, plastic deformation of structural glasses (in
particular amorphous silica) is characterized by a permanent densification.
Raman spectroscopic estimators are shown to give a full account of the plastic
behavior of silica under pressure. While the permanent densification of silica
has been widely discussed in terms of amorphous-amorphous transition, from a
plasticity point of view, the evolution of the residual densification with the
maximum pressure of a pressure cycle can be discussed as a density hardening
phenomenon. In the framework of such a mechanical aging effect, we propose that
the glass structure could be labelled by the maximum pressure experienced by
the glass and that the saturation of densification could be associated with the
densest packing of tetrahedra only linked by their vertices
Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension
Benoit Deschamps1, Naomi Musaji2, John A Gillespie21SFBC Anapharm, Montreal, Canada; 2Strativa Pharmaceuticals, a division of Par Pharmaceutical, Inc., Woodcliff Lake, NJ, USAObjective: Megestrol acetate oral suspension (MAOS) is an appetite stimulant indicated for cachexia in patients with AIDS. It is available in its original formulation, Megace® (MAOS), and as a nanocrystal dispersion, Megace® ES (MA-ES). Three studies were conducted to evaluate the pharmacokinetic properties of these formulations under fed and fasting conditions.Methods: An open-label, crossover trial was conducted in 24 healthy males randomized to MA-ES 625 mg/5 mL given with a high-calorie, high-fat meal, or after an overnight fast. Blood samples were drawn at multiple time points and pharmacokinetic parameters were determined. Two separate, open-label reference studies evaluated MAOS 800 mg/20 mL in 40 fed or 40 fasting healthy male volunteers.Results: In fasting MA-ES subjects, the average maximum concentration (Cmax) was 30% less than the fed Cmax value. For MAOS, fasting Cmax was 86% less than fed Cmax. In fasting subjects, the area under the curve was 12,095 ng⋅h/mL for MA-ES, and 8,942 ng⋅h/mL for MAOS. In fed subjects, the absorption of the two formulations was comparable.Conclusion: Bioavailability and absorption are greater for MA-ES than MAOS in fasting subjects. MA-ES may be a preferred formulation of megestrol acetate when managing cachectic patients whose caloric intake is reduced.Keywords: megestrol acetate, bioavailability, cachexia, nanocrystal technology, appetite stimulan
Implications of CP violating 2HDM in B physics
The charged fermion mass matrices are invariant under symmetry
linked to the fermion number transformation. Under the condition that the
definition of this symmetry in arbitrary weak basis does not depend upon Higgs
parameters such as ratio of vacuum expectation values, a class of two Higgs
doublet models (2HDM) can be identified in which tree level flavor changing
neutral currents normally present in 2HDM are absent. However unlike the type I
or type II Higgs doublet models, the charged Higgs couplings in these models
contain additional flavor dependent CP violating phases. These phases can
account for the recent hints of the beyond standard model CP violation in the
and mixing. In particular, there is a range of parameters in which
new phases do not contribute to the meson CP violation but give identical
new physics phases in the and meson mixing.Comment: 7 pages, 1 figure, Talk given by Bhavik P. Kodrani at 16th
International Symposium on Particles, Strings and Cosmology, July 19th -
23rd, 2010, Valencia, Spai
Estrutura da Pastagem e Produtividade de Forragem.
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