6,735 research outputs found

    Quantum Holography

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    We propose to make use of quantum entanglement for extracting holographic information about a remote 3-D object in a confined space which light enters, but from which it cannot escape. Light scattered from the object is detected in this confined space entirely without the benefit of spatial resolution. Quantum holography offers this possibility by virtue of the fourth-order quantum coherence inherent in entangled beams.Comment: 7 pages, submitted to Optics Expres

    ΠžΠΏΡ‚ΠΈΠΌΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΉ процСсс ΠΎΠ±ΠΌΠ΅Π½Π° Π΄Π°Π½Π½Ρ‹ΠΌΠΈ Π² ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈ производством

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    Growing vehicle variant diversity, legal requirements to reduce fleetΒ CO2 emissions and innovations in the area of drive train technologies, coupled with the increasing pressure to cut costs, pose new challenges for parties in the automotive sector. An implementation of optimized development and production processes supports the effective handling of these challenges. One important aspect includes engineering efficiency improvement by optimizing the entire automotive bodywork development process and the involved data management. Research activities focus on the data exchange processes between design, simulation and production engineering within various CAxΒ environments. This concerns constantly changing boundary conditions and requirements in the area of automotive body development, including but not limited to the introduction of new materials and material combinations and new types of joining technologies. From the viewpoint of an automotive engineering supplier, additional challenges caused by different customer-related development environments have to be considered. To overcome these challenges, various data exchange strategies between OEMs (Original Equipment Manufacturer), automotive suppliers and the use of different data management tools need to be investigated. In this context, the paper presents an approach of an optimized data exchange process of CAD-based data between different CAD (Computer-Aided Design) and CAM (Computer-Aided Manufacturing) environments that supports the entire body development, including data provision for manufacturing engineering. In addition, an optimization of data exchange processes saves development costs and improves the product quality.РастущСС Ρ€Π°Π·Π½ΠΎΠΎΠ±Ρ€Π°Π·ΠΈΠ΅ Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² транспортных срСдств, Π·Π°ΠΊΠΎΠ½ΠΎΠ΄Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ трСбования ΠΏΠΎ ΡΠΎΠΊΡ€Π°Ρ‰Π΅Π½ΠΈΡŽ выбросов CO2 ΠΈΠΌΠΈ, ΠΈΠ½Π½ΠΎΠ²Π°Ρ†ΠΈΠΈ Π² области Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ трансмиссии Π² сочСтании с ΡƒΡΠΈΠ»ΠΈΠ²Π°ΡŽΡ‰ΠΈΠΌΡΡ Π΄Π°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹ΠΌ Π½Π° сокращСниС расходов, ставят Π½ΠΎΠ²Ρ‹Π΅ Π·Π°Π΄Π°Ρ‡ΠΈ ΠΏΠ΅Ρ€Π΅Π΄ участниками Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ сСктора. Π’Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… процСссов Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΈ производства ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΈΠ²Π°Π΅Ρ‚ эффСктивноС Ρ€Π΅ΡˆΠ΅Π½ΠΈΠ΅ этих ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ. Одним ΠΈΠ· Π²Π°ΠΆΠ½Ρ‹Ρ… аспСктов являСтся ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ эффСктивности ΠΈΠ½ΠΆΠ΅Π½Π΅Ρ€Π½Ρ‹Ρ… Ρ€Π΅ΡˆΠ΅Π½ΠΈΠΉ Π·Π° счСт ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΠΈ всСго процСсса Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΊΡƒΠ·ΠΎΠ²Π° ΠΈ управлСния Π΄Π°Π½Π½Ρ‹ΠΌΠΈ. Π˜ΡΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΡΠΊΠ°Ρ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ сосрСдоточСна Π½Π° процСссах ΠΎΠ±ΠΌΠ΅Π½Π° Π΄Π°Π½Π½Ρ‹ΠΌΠΈ Π½Π° этапах проСктирования, модСлирования ΠΈ производства Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… срСдах БАх. Π­Ρ‚ΠΎ касаСтся постоянно ΠΌΠ΅Π½ΡΡŽΡ‰ΠΈΡ…ΡΡ Π³Ρ€Π°Π½ΠΈΡ‡Π½Ρ‹Ρ… условий ΠΈ Ρ‚Ρ€Π΅Π±ΠΎΠ²Π°Π½ΠΈΠΉ ΠΊ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ΅ ΠΊΡƒΠ·ΠΎΠ²ΠΎΠ² Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»Π΅ΠΉ, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ, ΠΏΠΎΠΌΠΈΠΌΠΎ ΠΏΡ€ΠΎΡ‡Π΅Π³ΠΎ, Π²Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ Π½ΠΎΠ²Ρ‹Ρ… ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ² ΠΈ ΠΈΡ… ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Ρ†ΠΈΠΉ, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π½ΠΎΠ²Ρ‹Ρ… Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ сборки. Π‘ Ρ‚ΠΎΡ‡ΠΊΠΈ зрСния поставщика Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»ΡŒΠ½ΠΎΠΉ Ρ‚Π΅Ρ…Π½ΠΈΠΊΠΈ, Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎ ΡƒΡ‡ΠΈΡ‚Ρ‹Π²Π°Ρ‚ΡŒ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹, Π²Ρ‹Π·Π²Π°Π½Π½Ρ‹Π΅ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ срСдами провСдСния Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ обусловлСны потрСбностями ΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚Π΅Π»Ρ. Π§Ρ‚ΠΎΠ±Ρ‹ Ρ€Π΅ΡˆΠΈΡ‚ΡŒ эти ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹, Π½ΡƒΠΆΠ½ΠΎ ΠΈΠ·ΡƒΡ‡ΠΈΡ‚ΡŒ стратСгии ΠΎΠ±ΠΌΠ΅Π½Π° Π΄Π°Π½Π½Ρ‹ΠΌΠΈ ΠΌΠ΅ΠΆΠ΄Ρƒ ΠžΠ•Πœ-производитСлями (ΠžΠ•Πœ – ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡ‚Π΅Π»ΡŒ ΠΎΡ€ΠΈΠ³ΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ оборудования) ΠΈ поставщиками Π°Π²Ρ‚ΠΎΠΌΠΎΠ±ΠΈΠ»Π΅ΠΉ с использованиСм Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… инструмСнтов. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСн ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΉ процСсс ΠΎΠ±ΠΌΠ΅Π½Π° Π΄Π°Π½Π½Ρ‹ΠΌΠΈ Π½Π° основС БАD (ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠ΅ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅) ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ срСдами CAD ΠΈ CAM (ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠ΅ производство), ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΈΠ²Π°Π΅Ρ‚ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΡƒ всСго ΠΊΡƒΠ·ΠΎΠ²Π°, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ прСдоставлСниС Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΡ‹Ρ… ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ для производствСнного Ρ†ΠΈΠΊΠ»Π°. ΠšΡ€ΠΎΠΌΠ΅ Ρ‚ΠΎΠ³ΠΎ, оптимизация процСссов ΠΎΠ±ΠΌΠ΅Π½Π° Π΄Π°Π½Π½Ρ‹ΠΌΠΈ позволяСт ΡƒΠΌΠ΅Π½ΡŒΡˆΠΈΡ‚ΡŒ Π·Π°Ρ‚Ρ€Π°Ρ‚Ρ‹ Π½Π° Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΡƒ ΠΈ ΡƒΠ»ΡƒΡ‡ΡˆΠΈΡ‚ΡŒ качСство ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ

    Actively Contracting Bundles of Polar Filaments

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    We introduce a phenomenological model to study the properties of bundles of polar filaments which interact via active elements. The stability of the homogeneous state, the attractors of the dynamics in the unstable regime and the tensile stress generated in the bundle are discussed. We find that the interaction of parallel filaments can induce unstable behavior and is responsible for active contraction and tension in the bundle. Interaction between antiparallel filaments leads to filament sorting. Our model could apply to simple contractile structures in cells such as stress fibers.Comment: 4 pages, 4 figures, RevTex, to appear in Phys. Rev. Let

    A projection proximal-point algorithm for l^1-minimization

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    The problem of the minimization of least squares functionals with β„“1\ell^1 penalties is considered in an infinite dimensional Hilbert space setting. While there are several algorithms available in the finite dimensional setting there are only a few of them which come with a proper convergence analysis in the infinite dimensional setting. In this work we provide an algorithm from a class which have not been considered for β„“1\ell^1 minimization before, namely a proximal-point method in combination with a projection step. We show that this idea gives a simple and easy to implement algorithm. We present experiments which indicate that the algorithm may perform better than other algorithms if we employ them without any special tricks. Hence, we may conclude that the projection proximal-point idea is a promising idea in the context of β„“1\ell^1-minimization

    Postoperative Breath-Holding Spells Requiring Cardiopulmonary Resuscitation After Cardiopulmonary Bypass

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    Breath-holding spells are common in childhood and can be associated with bradycardia and pulselessness. This report details severe breath-holding spells complicating postoperative management after atrial septal defect closure. The patient required cardiopulmonary resuscitation despite the use of a temporary pacemaker to prevent bradycardia. After multiple episodes of chest compressions, the decision was made to not intervene immediately to pulselessness and the patient was able to recover without further intervention

    Π£Π΄Π°Π»ΠΈΡ‚Π΅Π»ΠΈ для Π°ΡΡ„Π°Π»ΡŒΡ‚ΠΎΡΠΌΠΎΠ»ΠΎΠΏΠ°Ρ€Π°Ρ„ΠΈΠ½ΠΎΠ²Ρ‹Ρ… ΠΎΡ‚Π»ΠΎΠΆΠ΅Π½ΠΈΠΉ мСстороТдСний Π—Π°ΠΏΠ°Π΄Π½ΠΎΠ³ΠΎ ΠšΠ°Π·Π°Ρ…ΡΡ‚Π°Π½Π°

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    Signal transducers and activators of transcriptions (STAT) are key mediators of cytokine signaling. Moreover, these transcription factors play a crucial role in oncogenic signaling where inappropriate and sustained activation of STATs, especially STAT3, is a trait of many different cancers and their derived cell lines. Constitutively active STAT3 has been reported to prevent programmed cell death and enhance cell proliferation, whereas the disruption of STAT3 signaling can inhibit tumor growth. The physiologic activation of STAT3 by cytokines has been well established; however, little is known about altered, stimulation-independent STAT3 activation. Here, we show that, in most but not all melanoma cell lines, STAT3 phosphorylation increased substantially with cell density and that this STAT3 was able to bind to DNA and to activate transcription. Inhibitor studies showed that the cell density-dependent STAT3 activation relies on Janus kinases (JAK) rather than Src kinases. Using a specific JAK inhibitor, sustained STAT3 activation was completely abrogated in all tested melanoma lines, whereas inhibition of Src or mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 had no effect on constitutively tyrosine-phosphorylated STAT3 levels. Although STAT3 activation was completely blocked with JAK inhibitor I and to a lesser extent with the common JAK inhibitor AG490, only the latter compound markedly decreased proliferation and induced apoptosis. Taken together, variations in cell density can profoundly modify the extent of JAK-mediated persistent STAT3 phosphorylation; however, STAT3 activation was not sufficient to provide critical growth and survival signals in melanoma cell lines

    Small‐scale nutrient patchiness: Some consequences and a new encounter mechanism

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109816/1/lno19842940785.pd

    Walks of molecular motors in two and three dimensions

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    Molecular motors interacting with cytoskeletal filaments undergo peculiar random walks consisting of alternating sequences of directed movements along the filaments and diffusive motion in the surrounding solution. An ensemble of motors is studied which interacts with a single filament in two and three dimensions. The time evolution of the probability distribution for the bound and unbound motors is determined analytically. The diffusion of the motors is strongly enhanced parallel to the filament. The analytical expressions are in excellent agreement with the results of Monte Carlo simulations.Comment: 7 pages, 2 figures, to be published in Europhys. Let
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