Corrosion-protective coatings from electrically conducting polymers

In a joint effort between NASA Kennedy and LANL, electrically conductive polymer coatings were developed as corrosion protective coatings for metal surfaces. At NASA Kennedy, the launch environment consist of marine, severe solar, and intermittent high acid and/or elevated temperature conditions. Electrically conductive polymer coatings were developed which impart corrosion resistance to mild steel when exposed to saline and acidic environments. Such coatings also seem to promote corrosion resistance in areas of mild steel where scratches exist in the protective coating. Such coatings appear promising for many commercial applications

Deglaciation of Penobscot Bay, Maine, USA

The Pond Ridge and Pineo Ridge moraines in downeast Maine likely formed at ~16.1 and ~15.7 ka respectively, during cold episodes recorded by δ18O dips in the GRIP ice core. The elapsed time between these ages is broadly consistent with retreat rates recorded by intervening De Geer moraines, which are readily visible on LiDAR imagery and are believed to be approximately annual. North-northwestward from the southwesterly extension of the Pond Ridge moraine there are three pairs of prominent moraines that are relatively continuous across the study area and could be reliably extrapolated across intervening water bodies. Retreat rates recorded by De Geer moraines suggest that these pairs formed at 15.7-15.8 ka, 15.5-15.6 ka, and ~15.5 ka. Although retreat appears to have occurred slightly faster across Penobscot Bay, a significant calving bay does not seem to have developed there. Instead, the ice margin remained relatively straight, retreating to the north-northwest. De Geer moraines become more widely spaced northward and vanish after ~15.5 ka when the ice margin was north of the head of Penobscot Bay and of Pineo Ridge. This likely reflects higher retreat rates during the initial phases of the Bølling warm period. Just south of Pineo Ridge there were two ice lobes; one retreated to the north and one to the northwest. The latter retreated more rapidly, while the former experienced numerous minor readvances and stillstands until finally pausing at the location of Pineo Ridge. A stillstand of this lobe then resulted in deposition of the Pineo Ridge moraine complex

A Class of Transformations for Box‐Jenkins Seasonal Models

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147030/1/rssc00953.pd

Inferior vena cava branch variations in C57BL/6 mice have an impact on thrombus size in an IVC ligation (stasis) model

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110835/1/jth12866.pd

A novel protamine variant reversal of heparin anticoagulation in human blood in vitro

AbstractPurpose: Protamine reversal of heparin anticoagulation during cardiovascular surgery may cause severe hypotension and pulmonary hypertension. A novel protamine variant, [+18RGD], has been developed that effectively reverses heparin anticoagulation without toxicity in canine experiments. Heretofore, human studies have not been undertaken. This investigation hypothesized that [+18RGD] would effectively reverse heparin anticoagulation of human blood in vitro. Methods: Fifty patients who underwent anticoagulation therapy during vascular surgery had blood sampled at baseline and 30 minutes after receiving heparin (150 IU/kg). Activated clotting times were used to define specific quantities of [+18RGD] or protamine necessary to completely reverse heparin anticoagulation in the blood sample of each patient. These defined amounts of [+18RGD] or protamine were then administered to the heparinized blood samples, and percent reversals of activated partial thromboplastin time, thrombin clotting time, and antifactor Xa/IIa levels were determined. In addition, platelet aggregation assays, as well as platelet and white blood cell counts were performed. Results: [+18RGD] and protamine were equivalent in reversing heparin as assessed by thrombin clotting time, antifactor Xa, antifactor IIa levels, and white blood cell changes. [+18RGD], when compared with protamine, was superior in this regard, as assessed by activated partial thromboplastin time (94.5 ± 1.0 vs 86.5 ± 1.3%δ, respectively; p < 0.001) and platelet declines (–3.9 ± 2.9 vs –12.8 ± 3.4 per mm3, respectively; p = 0.048). Platelet aggregation was also decreased for [+18RGD] compared with protamine (23.6 ± 1.5 vs 28.5 ± 1.9%, respectively; p = 0.048). Conclusions: [+18RGD] was as effective as protamine for in vitro reversal of heparin anticoagulation by most coagulation assays, was statistically more effective at reversal than protamine by aPTT assay, and was associated with lesser platelet reductions than protamine. [+18RGD], if less toxic than protamine in human beings, would allow for effective clinical reversal of heparin anticoagulation. (J Vasc Surg 1997;26:1043-8.

Critical Review of Mouse Models of Venous Thrombosis

Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages