Data-Efficient, Federated Learning for Raw Network Traffic Detection

Traditional machine learning (ML) models used for enterprise network intrusion detection systems (NIDS) typically rely on vast amounts of centralized data with expertly engineered features. Previous work, however, has shown the feasibility of using deep learning (DL) to detect malicious activity on raw network traffic payloads rather than engineered features at the edge, which is necessary for tactical military environments. In the future Internet of Battlefield Things (IoBT), the military will find itself in multiple environments with disconnected networks spread across the battlefield. These resource-constrained, data-limited networks require distributed and collaborative ML/DL models for inference that are continually trained both locally, using data from each separate tactical edge network, and then globally in order to learn and detect malicious activity represented across the multiple networks in a collaborative fashion. Federated Learning (FL), a collaborative paradigm which updates and distributes a global model through local model weight aggregation, provides a solution to train ML/DL models in NIDS utilizing learning from multiple edge devices from the disparate networks without the sharing of raw data. We develop and experiment with a data-efficient, FL framework for IoBT settings for intrusion detection using only raw network traffic in restricted, resource-limited environments. Our results indicate that regardless of the DL model architecture used on edge devices, the Federated Averaging FL algorithm achieved over 93% accuracy in model performance in detecting malicious payloads after only five episodes of FL training

Chronic inflammatory neuropathies and their impact on activities and participation

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are inflammatory neuropathies that can lead to considerable limitations in daily activities and in social participation. However, systematic evaluation of these self-reported limitations is lacking in the currently available studies. Understanding the impact of these diagnoses on patients' life is important to optimize management strategies.Aim: To systematically assess the self-reported limitations in activities and participation and determine associated factors.Methods: A survey study was conducted in 2021 in a cohort of patients with CIDP (n = 257) and MMN (n = 148) from a university hospital. The survey included the Rasch-built Overall Disability Scale and the Utrecht Scale for Evaluation of Rehabilitation-Participation, questions addressing personal and disease-related factors and treatment. Multivariate linear regression analysis was used to determine associations with disease-related and personal factors.Results: A total of 147 CIDP and 103 MMN patients responded. Limitations in activities were reported by 70.7% CIDP and 52.2% MMN patients with moderate to severe limitations in 22.4% and 5.9% patients, respectively. Participation restrictions were reported by 50% of CIDP and 40% of MMN patients, nevertheless satisfaction with participation was high. Fatigue, pain and resilience were independently associated with limitations in activities and satisfaction with participation in CIDP patients.Conclusions: Activity limitations and restrictions in participation are common in CIDP patients and to a lesser extent in MMN patients. Fatigue, pain and resilience independently contributed to perceived limitations in CIDP patients. Referral to a rehabilitation physician is warranted to address these limitations appropriately.</p

Collection efficiency and design of microbial air samplers

The variables affecting the physical collection efficiency of air samplers of the type that impact microbe-carrying particles onto agar were investigated using a simplified analytical method and computational fluid dynamics. The results from these two techniques were compared, as were the effect of jet velocity, nozzle size, and nozzle distance from the agar surface; also considered was the optimisation of these variables to obtain an efficient design of sampler. A technique is described that calculates the proportion of microbe-carrying particles that a sampler will collect from a typical size distribution of microbe-carrying particles found in an occupied room; the three air samplers studied were found to collect from about 22% to over 99% of the micro-organisms in the room air

Educational paper: Imaging child abuse: the bare bones

Fractures are reported to be the second most common findings in child abuse, after skin lesions such as bruises and contusions. This makes careful interpretation of childhood fractures in relation to the provided clinical history important. In this literature review, we address imaging techniques and the prevailing protocols as well as fractures, frequently seen in child abuse, and the differential diagnosis of these fractures. The use of a standardised protocol in radiological imaging is stressed, as adherence to the international guidelines has been consistently poor. As fractures are a relatively common finding in childhood and interpretation is sometimes difficult, involvement of a paediatric radiologist is important if not essential. Adherence to international guidelines necessitates review by experts and is therefore mandatory. As in all clinical differential diagnoses, liaison between paediatricians and paediatric radiologists in order to obtain additional clinical information or even better having joint review of radiological studies will improve diagnostic accuracy. It is fundamental to keep in mind that the diagnosis of child abuse can never be solely based on radiological imaging but always on a combination of clinical, investigative and social findings. The quality and interpretation, preferably by a paediatric radiologist, of radiographs is essential in reaching a correct diagnosis in cases of suspected child abuse

Polarized Signatures of a Habitable World: Comparing Models of an Exoplanet Earth with Visible and Near-infrared Earthshine Spectra

In the JWST, Extremely Large Telescopes, and LUVOIR era, we expect to characterize a number of potentially habitable Earth-like exoplanets. However, the characterization of these worlds depends crucially on the accuracy of theoretical models. Validating these models against observations of planets with known properties will be key for the future characterization of terrestrial exoplanets. Due to its sensitivity to the micro- and macro-physical properties of an atmosphere, polarimetry will be an important tool that, in tandem with traditional flux-only observations, will enhance the capabilities of characterizing Earth-like planets. In this paper we benchmark two different polarization-enabled radiative-transfer codes against each other and against unique linear spectropolarimetric observations of the earthshine that cover wavelengths from $\sim$0.4 to $\sim$2.3 $\mu$m. We find that while the results from the two codes generally agree with each other, there is a phase dependency between the compared models. Additionally, with our current assumptions, the models from both codes underestimate the level of polarization of the earthshine. We also report an interesting discrepancy between our models and the observed 1.27 $\mu$m $O_2$ feature in the earthshine, and provide an analysis of potential methods for matching this feature. Our results suggest that only having access to the 1.27 $\mu$m $O_2$ feature coupled with a lack of observations of the $O_2$ A and B bands could result in a mischaracterization of an Earth-like atmosphere. Providing these assessments is vital to aid the community in the search for life beyond the solar system.Comment: 24 pages, 18 figure

Early experience with the ARTISENTIAL® articulated instruments in laparoscopic low anterior resection with TME

Background: The notion of articulation in surgery has been largely synonymous with robotics. The ARTISENTIAL® instruments aim at bringing advanced articulation to laparoscopy to overcome challenges in narrow anatomical spaces. In this paper, we present first single-center results of a series of low anterior resections, performed with ARTISENTIAL®. Methods: Between September 2020 and August 2021, at the Department of Surgery, St. Marienkrankenhaus Siegen, Siegen, Germany, patients with cancer of the mid- and low rectum were prospectively enrolled in a pilot feasibility study to evaluate the ARTISENTIAL® articulated instruments in performing a laparoscopic low anterior resection. Perioperative and short-term postoperative data were analyzed. Results: Seventeen patients (10 males/7 females) were enrolled in this study. The patients had a median age of 66 years (range 47–80 years) and a median body mass index of 28 kg/m2 (range 23–33 kg/m2). The median time to rectal transection was 155 min (range 118–280 min) and the median total operative time was 276 min (range 192–458 min). The median estimated blood loss was 30 ml (range 5–70 ml) and there were no conversions to laparotomy. The median number of harvested lymph nodes was 15 (range 12–28). Total mesorectal excision (TME) quality was ‘good’ in all patients with no cases of circumferential resection margin involvement (R0 = 100%). The median length of stay was 9 days (range 7–14 days). There were no anastomotic leaks and the overall complication rate was 17.6%. There was one unrelated readmission with no mortality. Conclusions: Low anterior resection with ARTISENTIAL® is feasible and safe. All patients had a successful TME procedure with a good oncological outcome. We will now seek to evaluate the benefits of ARTISENTIAL® in comparison with standard laparoscopic instruments through a larger study

The in vivo phosphorylation sites of bovine αB-crystallin

AbstractPhosphate content determinations established that in αB-crystallin two phosphate groups can be present in vivo in bovine lenses. Comparison of tryptic digests of phosphorylated and unphosphorylated αB chains, revealed the location of the two phosphorylation sites in tryptic peptides T2 and T3. Thermolytic digestion and gas-phase sequencing demonstrated that Ser-19 and Ser-45 are the in vivo phosphorylation sites of bovine αB-crystallin. This pattern of phosphorylation differs from the previously reported in vitro obtained results

Stress-Induced Allodynia – Evidence of Increased Pain Sensitivity in Healthy Humans and Patients with Chronic Pain after Experimentally Induced Psychosocial Stress

Background: Experimental stress has been shown to have analgesic as well as allodynic effect in animals. Despite the obvious negative influence of stress in clinical pain conditions, stress-induced alteration of pain sensitivity has not been tested in humans so far. Therefore, we tested changes of pain sensitivity using an experimental stressor in ten female healthy subjects and 13 female patients with fibromyalgia. Methods: Multiple sensory aspects of pain were evaluated in all participants with the help of the quantitative sensory testing protocol before (60 min) and after (10 and 90 min) inducing psychological stress with a standardized psychosocial stress test (“Trier Social Stress Test”). Results: Both healthy subjects and patients with fibromyalgia showed stress-induced enhancement of pain sensitivity in response to thermal stimuli. However, only patients showed increased sensitivity in response to pressure pain. Conclusions: Our results provide evidence for stress-induced allodynia/hyperalgesia in humans for the first time and suggest differential underlying mechanisms determining response to stressors in healthy subjects and patients suffering from chronic pain. Possible mechanisms of the interplay of stress and mediating factors (e.g. cytokines, cortisol) on pain sensitivity are mentioned. Future studies should help understand better how stress impacts on chronic pain conditions