Investigation of the Nicole model

We study soliton solutions of the Nicole model - a non-linear four-dimensional field theory consisting of the CP^1 Lagrangian density to the non-integer power 3/2 - using an ansatz within toroidal coordinates, which is indicated by the conformal symmetry of the static equations of motion. We calculate the soliton energies numerically and find that they grow linearly with the topological charge (Hopf index). Further we prove this behaviour to hold exactly for the ansatz. On the other hand, for the full three-dimensional system without symmetry reduction we prove a sub-linear upper bound, analogously to the case of the Faddeev-Niemi model. It follows that symmetric solitons cannot be true minimizers of the energy for sufficiently large Hopf index, again in analogy to the Faddeev-Niemi model.Comment: Latex, 35 pages, 1 figur

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positively modulates the YAP mechanoresponse to substrate stiffness through actin-cytoskeleton-dependent and Hippo-kinase-independent mechanisms. RHO activity is necessary, but not sufficient, for CAV1-dependent mechanoregulation of YAP activity. Systematic quantitative interactomic studies and image-based small interfering RNA (siRNA) screens provide evidence that this actin-dependent regulation is determined by YAP interaction with the 14-3-3 protein YWHAH. Constitutive YAP activation rescued phenotypes associated with CAV1 loss, including defective extracellular matrix (ECM) remodeling. CAV1-mediated control of YAP activity was validated in vivo in a model of pancreatitis-driven acinar-to-ductal metaplasia. We propose that this CAV1-YAP mechanotransduction system controls a significant share of cell programs linked to these two pivotal regulators, with potentially broad physiological and pathological implications. Moreno-Vicente et al. report that CAV1, a key component of PM mechanosensing caveolae, mediates adaptation to ECM rigidity by modulating YAP activity through the control of actin dynamics and phosphorylation-dependent interaction of YAP with the 14-3-3-domain protein YWHAH. Cav1-dependent YAP regulation drives two pathophysiological processes: ECM remodeling and pancreatic ADM. © 2018 The Author

Protocols of the EU bottom trawl survey of Flemish Cap

Methods and procedures used in the EU bottom trawl survey of Flemish Cap (NAFO Division 3M) are described in detail. The objectives of publicising these protocols are to achieve a better understanding of its results, and to contribute to the routines being unaltered

Knowledge Networks around the Strategic Alliances of Micro Coffee Producers

The organizational process that goes from the knowledge networks to the strategic alliances supposes a management, production and transfer of information that the literature differentiates according to the degree of empathy, commitment, entrepreneurship, innovation and satisfaction of leaders and followers. In this sense, the objective of this study was to study the phenomenon in coffee growers in central Mexico. From a structural model ⌠X 2 = 321.23 (34gl) p = 0.009; GFI = 0.990; CFI = 0.975; RMSEA = 0.008⌡, after establishing the reliability and validity of an instrument, it was found that innovation determines satisfaction (0.51), although the type of study, sample selection and analysis limit the findings to the specific context of the investigation. Lines concerning the extension of work to different contexts and samples are noticed

An approach to identify urban groundwater recharge

Evaluating the proportion in which waters from different origins are mixed in a given water sample is relevant for many hydrogeological problems, such as quantifying total recharge, assessing groundwater pollution risks, or managing water resources. Our work is motivated by urban hydrogeology, where waters with different chemical signature can be identified (losses from water supply and sewage networks, infiltration from surface runoff and other water bodies, lateral aquifers inflows, ...). The relative contribution of different sources to total recharge can be quantified by means of solute mass balances, but application is hindered by the large number of potential origins. Hence, the need to incorporate data from a large number of conservative species, the uncertainty in sources concentrations and measurement errors. We present a methodology to compute mixing ratios and end-members composition, which consists of (i) Identification of potential recharge sources, (ii) Selection of tracers, (iii) Characterization of the hydrochemical composition of potential recharge sources and mixed water samples, and (iv) Computation of mixing ratios and reevaluation of end-members. The analysis performed in a data set from samples of the Barcelona city aquifers suggests that the main contributors to total recharge are the water supply network losses (22%), the sewage network losses (30%), rainfall, concentrated in the non-urbanized areas (17%), from runoff infiltration (20%), and the Besòs River (11%). Regarding species, halogens (chloride, fluoride and bromide), sulfate, total nitrogen, and stable isotopes (<sup>18</sup>O, <sup>2</sup>H, and <sup>34</sup>S) behaved quite conservatively. Boron, residual alkalinity, EDTA and Zn did not. Yet, including these species in the computations did not affect significantly the proportion estimations

Evaluation of two MM5-PBL parameterizations for solar radiation and temperature estimation in the South-Eastern area of the Iberian Peninsula

We study the relative performance of two different MM5-PBL parameterizations (Blackadar and MRF) simulating hourly values of solar irradiance and temperature in the south-eastern part of the Iberian Peninsula. The evaluation was carried out throughout the different seasons of the year 2005 and for three different sky conditions: clear-sky, broken-clouds and overcast conditions. Two integrations, one per PBL parameterization, were carried out for every sky condition and season of the year and results were compared with observational data. Overall, the MM5 model, both using the Blackadar or MRF PBL parameterization, revealed to be a valid tool to estimate hourly values of solar radiation and temperature over the study area. The influence of the PBL parameterization on the model estimates was found to be more important for the solar radiation than for the temperature and highly dependent on the season and sky conditions. Particularly, a detailed analysis revealed that, during broken-clouds conditions, the ability of the model to reproduce hourly changes in the solar radiation strongly depends upon the selected PBL parameterization. Additionally, it was found that solar radiation RMSE values are about one order of magnitude higher during broken-clouds and overcast conditions compared to clear-sky conditions. For the temperature, the two PBL parameterizations provide very similar estimates. Only under overcast conditions and during the autumn, the MRF provides significantly better estimates

Analysis of the power balance In the cells of a multilevel cascaded H-Bridge converter

Multilevel cascaded H-Bridge converters (CHB) have been presented as a good solution for high power applications. In this way, several control and modulation techniques have been proposed for this power converter topology. In this paper the steady state power balance in the cells of the single phase two cell CHB is studied. The capability to be supplied with active power from the grid or to deliver active power to the grid in each cell is analyzed according to the dc-link voltages and the desired ac output voltage value. Limits of the maximum and minimum input active power for stable operation of the CHB are addressed. Simulation results are shown to validate the presented analysis