Droplet Breakup in Flow Past an Obstacle: A Capillary Instability Due to Permeability Variations

In multiphase flow in confined geometries an elementary event concerns the interaction of a droplet with an obstacle. As a model of this configuration we study the collision of a droplet with a circular post that spans a significant fraction of the cross-section of a microfluidic channel. We demonstrate that there exist conditions for which a drop moves completely around the obstacle without breaking, while for the same geometry but higher speeds the drop breaks. Therefore, we identify a critical value of the capillary number above which a drop will break. We explain the results with a one-dimensional model characterizing the flow in the narrow gaps on either side of the obstacle, which identifies a surface-tension–driven instability associated with a variation in the permeability in the flow direction. The model captures the major features of the experimental observations.Harvard University (MRSEC (DMR-0820484))Schlumberger-Doll Research Cente

Deformation Mechanisms Rationalisation to Design for Creep Resistance in Polycrystalline Ni-Based Superalloys

Creep strength in polycrystalline Ni-based superalloys is influenced by the formation of a rich variety of planar faults forming within the strengthening γ' phase. The lengthening and thickening rate of these faults – and therefore the creep rate – depends on an intriguing combination of dislocation interactions at the γ-γ' interface and diffusional processes of the alloying elements at the core of the fault tip. The effect of alloy composition on this process is not fully understood. In this work we use correlative high resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy to study the deformation faults in two different Ni-based superalloys with carefully designed ratios of disordering-to-ordering-promoting elements (Co-Cr against Nb-Ta-Ti). The results show that the additions of ordering-promoting elements reduce the diffusional processes required for the faults to lengthen and thicken thus reducing the creep rates found for the higher Nb-Ta-Ti alloy. These insights provide a path to follow in the design of improved grades of creep-resistant polycrystalline alloys beyond 700 C

Novel Defect Structures in Nematic Liquid Crystal Shells

We use double-emulsion drops to experimentally investigate the defect structures of spherical shells of nematic liquid crystals. We uncover a rich scenario of coexisting defect structures dictated by the unavoidable finite thickness of even the thinnest shell and by the thickness variation around the sphere. These structures are characterized by a varying number of disclination lines and pairs of surface point defects on the inner and outer surfaces of the nematic shell. In the limit of very thick shells the defect structure ultimately merges with that of a bulk nematic liquid crystal drop

Gas Dynamic Virtual Nozzle for Generation of Microscopic Droplet Streams

As shown by Ganan-Calvo and co-workers, a free liquid jet can be compressed in iameter through gas-dynamic forces exerted by a co-flowing gas, obviating the need for a solid nozzle to form a microscopic liquid jet and thereby alleviating the clogging problems that plague conventional droplet sources of small diameter. We describe in this paper a novel form of droplet beam source based on this principle. The source is miniature, robust, dependable, easily fabricated, and eminently suitable for delivery of microscopic liquid droplets, including hydrated biological samples, into vacuum for analysis using vacuum instrumentation. Monodisperse, single file droplet streams are generated by triggering the device with a piezoelectric actuator. The device is essentially immune to clogging

Preparation of Large Monodisperse Vesicles

Preparation of monodisperse vesicles is important both for research purposes and for practical applications. While the extrusion of vesicles through small pores (∼100 nm in diameter) results in relatively uniform populations of vesicles, extrusion to larger sizes results in very heterogeneous populations of vesicles. Here we report a simple method for preparing large monodisperse multilamellar vesicles through a combination of extrusion and large-pore dialysis. For example, extrusion of polydisperse vesicles through 5-µm-diameter pores eliminates vesicles larger than 5 µm in diameter. Dialysis of extruded vesicles against 3-µm-pore-size polycarbonate membranes eliminates vesicles smaller than 3 µm in diameter, leaving behind a population of monodisperse vesicles with a mean diameter of ∼4 µm. The simplicity of this method makes it an effective tool for laboratory vesicle preparation with potential applications in preparing large monodisperse liposomes for drug delivery

γ-Heregulin has no biological significance in primary breast cancer

British Journal of Cancer (2002) 86, 1362–1363. DOI: 10.1038/sj/bjc/6600245 www.bjcancer.co