The sixth Painleve equation arising from D_4^{(1)} hierarchy

The sixth Painleve equation arises from a Drinfel'd-Sokolov hierarchy associated with the affine Lie algebra of type D_4 by similarity reduction.Comment: 14 page

Competition between Magnetic and Structural Transition in CrN

CrN is observed to undergo a paramagnetic to antiferromagnetic transition accompanied by a shear distortion from cubic NaCl-type to orthorhombic structure. Our first-principle plane wave and ultrasoft pseudopotential calculations confirm that the distorted antiferromagnetic phase with spin configuration arranged in double ferromagnetic sheets along [110] is the most stable. Antiferromagnetic ordering leads to a large depletion of states around Fermi level, but it does not open a gap. Simultaneous occurence of structural distortion and antiferromagnetic order is analyzed.Comment: 10 pages, 10 figure

Exploration of a 100 TeV gamma-ray northern sky using the Tibet air-shower array combined with an underground water-Cherenkov muon-detector array

Aiming to observe cosmic gamma rays in the 10 - 1000 TeV energy region, we propose a 10000 m^2 underground water-Cherenkov muon-detector (MD) array that operates in conjunction with the Tibet air-shower (AS) array. Significant improvement is expected in the sensitivity of the Tibet AS array towards celestial gamma-ray signals above 10 TeV by utilizing the fact that gamma-ray-induced air showers contain far fewer muons compared with cosmic-ray-induced ones. We carried out detailed Monte Carlo simulations to assess the attainable sensitivity of the Tibet AS+MD array towards celestial TeV gamma-ray signals. Based on the simulation results, the Tibet AS+MD array will be able to reject 99.99% of background events at 100 TeV, with 83% of gamma-ray events remaining. The sensitivity of the Tibet AS+MD array will be ~20 times better than that of the present Tibet AS array around 20 - 100 TeV. The Tibet AS+MD array will measure the directions of the celestial TeV gamma-ray sources and the cutoffs of their energy spectra. Furthermore, the Tibet AS+MD array, along with imaging atmospheric Cherenkov telescopes as well as the Fermi Gamma-ray Space Telescope and X-ray satellites such as Suzaku and MAXI, will make multiwavelength observations and conduct morphological studies on sources in the quest for evidence of the hadronic nature of the cosmic-ray acceleration mechanism.Comment: Accepted by Astroparticle Physic

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype. As part of FANTOM4, we used microarrays to identify 23 microRNAs that are regulated by PMA. We identify four PMA-induced micro- RNAs (mir-155, mir-222, mir-424 and mir-503) that when overexpressed cause cell-cycle arrest and partial differentiation and when used in combination induce additional changes not seen by any individual microRNA. We further characterize these prodifferentiative microRNAs and show that mir-155 and mir-222 induce G2 arrest and apoptosis, respectively. We find mir-424 and mir-503 are derived from a polycistronic precursor mir-424-503 that is under repression by the MLL-MLLT3 leukemogenic fusion. Both of these microRNAs directly target cell-cycle regulators and induce G1 cell-cycle arrest when overexpressed in THP-1. We also find that the pro-differentiative mir-424 and mir-503 downregulate the anti-differentiative mir-9 by targeting a site in its primary transcript. Our study highlights the combinatorial effects of multiple microRNAs within cellular systems.Comment: 45 pages 5 figure

Excitons and charged excitons in semiconductor quantum wells

A variational calculation of the ground-state energy of neutral excitons and of positively and negatively charged excitons (trions) confined in a single-quantum well is presented. We study the dependence of the correlation energy and of the binding energy on the well width and on the hole mass. The conditional probability distribution for positively and negatively charged excitons is obtained, providing information on the correlation and the charge distribution in the system. A comparison is made with available experimental data on trion binding energies in GaAs-, ZnSe-, and CdTe-based quantum well structures, which indicates that trions become localized with decreasing quantum well width.Comment: 9 pages, 11 figure