CLIC Background Studies and optimization of the innermost tracker elements

The harsh machine background at the Compact Linear Collider (CLIC) forms a strong constraint on the design of the innermost part of the tracker. For the CLIC Conceptual Design Report, the detector concepts developed for the International Linear Collider (ILC) were adapted to the CLIC environment. We present the new layout for the Vertex Detector and the Forward Tracking Disks of the CLIC detector concepts, as well as the background levels in these detectors. We also study the dependence of the background rates on technology parameters like thickness of the active layer and detection threshold.Comment: 7 pages, 5 figures, LCWS 201

Geiger-Mode Avalanche Photodiodes in Particle Detection

It is well known that avalanche photodiodes operated in the Geiger mode above the breakdown voltage offer a virtually infinite sensitivity and time accuracy in the picosecond range that can be used for single photon detection. However, their performance in particle detection remains still unexplored. In this contribution, we are going to expose the different steps that we have taken in order to prove the efficiency of Geiger mode avalanche photodiodes in the aforementioned field. In particular, we will present an array of pixels of 1mmx1mm fabricated with a standard CMOS technology for characterization in a test beam.Comment: 7 pages, 2 figures, Proceedings of LCWS1

Tracking collective cell motion by topological data analysis

By modifying and calibrating an active vertex model to experiments, we have simulated numerically a confluent cellular monolayer spreading on an empty space and the collision of two monolayers of different cells in an antagonistic migration assay. Cells are subject to inertial forces and to active forces that try to align their velocities with those of neighboring ones. In agreement with experiments, spreading tests exhibit finger formation in the moving interfaces, swirls in the velocity field, and the polar order parameter and correlation and swirl lengths increase with time. Cells inside the tissue have smaller area than those at the interface, as observed in recent experiments. In antagonistic migration assays, a population of fluidlike Ras cells invades a population of wild type solidlike cells having shape parameters above and below the geometric critical value, respectively. Cell mixing or segregation depends on the junction tensions between different cells. We reproduce experimentally observed antagonistic migration assays by assuming that a fraction of cells favor mixing, the others segregation, and that these cells are randomly distributed in space. To characterize and compare the structure of interfaces between cell types or of interfaces of spreading cellular monolayers in an automatic manner, we apply topological data analysis to experimental data and to numerical simulations. We use time series of numerical simulation data to automatically group, track and classify advancing interfaces of cellular aggregates by means of bottleneck or Wasserstein distances of persistent homologies. These topological data analysis techniques are scalable and could be used in studies involving large amounts of data. Besides applications to wound healing and metastatic cancer, these studies are relevant for tissue engineering, biological effects of materials, tissue and organ regeneration.Comment: 34 pages, 25 figures, the final version will appear in PLoS Computational Biolog

No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a powerful treatment in Parkinson’s disease (PD), which provides a positive effect on motor symptoms although the way it operates on high cognitive processes such as metacognition remains unclear. To address this issue, we recorded electroencephalogram (EEG) of PD patients treated with STN-DBS that performed a reversal learning (RL) paradigm endowed with metacognitive self-assessment. We considered two stimulation conditions, namely DBS-ON (stimulation on) and DBS-OFF (stimulation off), and focused our EEG-analysis on the frontal brain region due to its involvement on high cognitive processes. We found a trend towards a significant difference in RL ability between stimulation conditions. STN-DBS showed no effect on metacognition, although a significant association between accuracy and decision confidence level held for DBS OFF, but not in the case of DBS ON. In summary, our study revealed no significant effect of STN-DBS on RL or metacognition

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

Transcranial pulse stimulation (TPS) is a non-invasive neuromodulation therapy that uses short, repetitive shockwaves through a neuro-navigated device. Current research suggests that these pulses lead to a wide range of vascular, metabolic, and neurotrophic changes. This relatively new CE-marked treatment provided first promising results in a clinical pilot study for improving cognition in mild-to-moderate Alzheimer's. Data from other centers is lacking, so here we analyzed safety and pilot real-world short-term results of TPS from the first center in Germany. To gain information about effects in different stages, patients with not only mild but also moderate-to-severe Alzheimer's were analyzed

Impact of low-interest credits on business R&D expenditures: Spanish firms and CDTI loans for R&D projects

Our objective is to estimate the effect of low-interest loans for R&D projects on business R&D. We take into account that the participation of firms in this kind of public programme probably depends on the same characteristics that determine their investment decisions. We also consider the possibility of persistence in R&D expenditures over time. The estimations provide evidence of the effectiveness of low-interest loans, being the stimulus effect larger for SMEs than for large firms and also higher for manufacturing than for services. Participants are approximately 25 percentage points more likely to self-finance their R&D investments than non-supported firms. The effect is quite relevant if we consider that the probability of self-financing R&D activities is 53.2 percentage points higher when the firm has invested in R&D activities in the previous year. This result suggests that firms can be induced persistently to perform R&D activities by means of loans

Impact of low-interest credits on business R&D expenditures: Spanish firms and CDTI loans for R&D projects

Our objective is to estimate the effect of low-interest loans for R&D projects on business R&D. We take into account that the participation of firms in this kind of public programme probably depends on the same characteristics that determine their investment decisions. We also consider the possibility of persistence in R&D expenditures over time. The estimations provide evidence of the effectiveness of low-interest loans, being the stimulus effect larger for SMEs than for large firms and also higher for manufacturing than for services. Participants are approximately 25 percentage points more likely to self-finance their R&D investments than non-supported firms. The effect is quite relevant if we consider that the probability of self-financing R&D activities is 53.2 percentage points higher when the firm has invested in R&D activities in the previous year. This result suggests that firms can be induced persistently to perform R&D activities by means of loans

Aprovechamiento de barros procedentes de central de áridos para la elaboración de piezas cerámicas porosas

Aggregates (gravel and sand) are, after water, the Earth’s second most used natural resource, representing about 50% of all consumed mineral resources. Aggregate production generates a large quantity of waste from the aggregate washing process. This waste is made up of suspended solids – sludge – which has a great environmental impact. It is deposited in huge troughs because of the impossibility of discharging it directly into rivers. Many plants have incorporated decanters and filter presses to separate the solid from the liquid fraction. This paper evaluates the possibility of exploiting the solid fraction (i.e. sludge) in the manufacture of fired clay bricks. The added value of these bricks is, on the one hand, the exploitation of sludge as a currently useless waste product, and on the other, the use of this sludge to enhance the physical and mechanical properties of conventional fired clay bricks.Los áridos son la segunda materia prima más consumida en la Tierra después del agua, representando alrededor del 50% de todos los recursos minerales consumidos. El proceso de elaboración de estos áridos genera una gran cantidad de residuos procedentes de su lavado. Se trata de partículas sólidas en suspensión – lodos – de gran impacto ambiental, que se depositan en grandes charcas ante la imposibilidad de verterlos directamente al rio. Muchas empresas han incorporado decantadores y filtros de prensa para separar la fracción solida de la líquida. El presente trabajo evalúa la posibilidad de utilizar la fracción sólida, es decir el barro, para la fabricación de piezas cerámicas. El valor añadido de estas piezas es por un lado el aprovechamiento del barro como producto residual, que en estos momentos es desechable, y por otro, conseguir que este barro mejore las propiedades físico-mecánicas de la cerámica convencional

Potencial redox en suelos de la zona de Cabo de Gata (Almería)

En el presente trabajo estudiamos la relación entre el potencial redox y una serie de factores que lo condicionan, en un total de ocho perfiles procedentes de la zona de Cabo de Gata (Almeria) y desarrollados todos ellos sobre roca caliza o rica en carbonato cálcico bajo clima subdesérticocálido. Encontramos que el valer del Eh está relacionado con los contenidos en materia orgánica y manganeso y con el valor del pH, en cambio no guarda relación con el contenido en hierro.In the present papel' we study the relationship among redox potential and some of the factors that they condition it, in eight soil profils from Cabo de Gata región (Almeria-Spain), all them al'e developed on limestone or other richo in calcium carbonate, rocks. The climate is warm subdesertic. We found the Eh value Eh related with the amounts of organic matter and manganese and the pH value. The Eh value is not related with the iron content

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

Contains fulltext : 170288.pdf (publisher's version ) (Open Access)CD4+FOXP3+ Treg are essential for immune tolerance. Phase-1 clinical trials of Treg-therapy to treat graft-versus-host-disease reported safety and potential therapeutic efficacy. Treg-based trials have started in organ-transplant patients. However, efficient ex vivo expansion of a stable Treg population remains a challenge and exploring novel ways for Treg expansion is a pre-requisite for successful immunotherapy. Based on the recent finding that CD28-signaling is crucial for survival and proliferation of mouse Treg, we studied single-CD28 stimulation of human Treg, without T cell receptor stimulation. Single-CD28 stimulation of human Treg in the presence of recombinant human IL-2(rhIL-2), as compared to CD3/CD28/rhIL-2 stimulation, led to higher expression levels of FOXP3. Although the single-CD28 expanded Treg population was equally suppressive to CD3/CD28 expanded Treg, pro-inflammatory cytokine (IL-17A/IFNgamma) production was strongly inhibited, indicating that single-CD28 stimulation promotes Treg stability. As single-CD28 stimulation led to limited expansion rates, we examined a CD28-superagonist antibody and demonstrate a significant increased Treg expansion that was more efficient than standard anti-CD3/CD28-bead stimulation. CD28-superagonist stimulation drove both naive and memory Treg proliferation. CD28-superagonist induction of stable Treg appeared both PI3K and mTOR dependent. Regarding efficient and stable expansion of Treg for adoptive Treg-based immunotherapy, application of CD28-superagonist stimulation is of interest