Cryogenic hyperabrupt strontium titanate varactors for sensitive reflectometry of quantum dots

<p>Supplementary Data for:</p> <p>"Cryogenic hyperabrupt strontium titanate varactors for sensitive reflectometry of quantum dots"</p> <p>Rafael S. Eggli, Simon Svab,Taras Patlatiuk, Dominique Trüssel, Miguel J. Carballido, Pierre Chevalier Kwon, Simon Geyer, Ang Li,<br> Erik P. A. M. Bakkers, Andreas V. Kuhlmann, and Dominik M. Zumbühl</p&gt

A biomimetic approach for enhancing the in vivo half-life of peptides

The tremendous therapeutic potential of peptides has not yet been realized, mainly due to their short in vivo half-life. While conjugation to macromolecules has been a mainstay approach for enhancing the half-life of proteins, the steric hindrance of macromolecules often harms the binding of peptides to target receptors, compromising the in vivo efficacy. Here we report a new strategy for enhancing the in vivo half-life of peptides without compromising their potency. Our approach involves endowing peptides with a small-molecule that binds reversibly to the serum protein, transthyretin. Although there are few reversible albumin-binding molecules, we are unaware of designed small molecules that bind reversibly to other serum proteins and are used for half-life extension in vivo. We show here that our strategy was indeed effective in enhancing the half-life of an agonist for GnRH receptor while maintaining its binding affinity, which was translated into superior in vivo efficacy

Bone mechanobiology in mice: toward single-cell in vivo mechanomics

ISSN:1617-7959ISSN:1617-794