Description of Methods of Conservative Treatment of Osteoarthritis of the Knee Joint

Osteoarthritis (OA) is a chronic progressive degenerative joint disease characterized by degradation of articular cartilage, in which subchondral changes in the bone and the development of facet osteophytes are observed. These changes lead to degradation of the articular taiga and its other components (synovial fundus, bones).Radiological signs of the disease are observed in people over 65 years of age and in more than 80% of people over 75 years of age.Osteoarthritis of the knee joint is a common disease among the common diseases of degenerative-dystrophic joint diseases leading to orthopedics. Recently, there has been a tendency to increase gonarthrosis in the armpits of young animals working on leiocatlicism

Application of Plate Autoplasma in Treatment of Osteoarthrosis and Its Clinical Effectiveness

Proposed injection treatment osteoarthroses based Plasmolifting method stimulate the regeneration of tissues with the use of autoplasma containing blood platelets. Methods of treatment with the use of platelet autoplasma in the treatment of osteoarthrosis of this technology is easy to use, does not require sophisticated equipment can take the pain, improve joint mobility, to promote processes of restoration of cartilage, bone and soft tissue of the joint, to prolong the period of remission of the disease

The Use of Platelet Autoplasm in the Treatment of Osteoarthritis and Its Clinical Effectiveness

Proposed injection treatment osteoarthroses based Plasmolifting method stimulate the regeneration of tissues with the use of autoplasma containing blood platelets. Methods of treatment with the use of platelet autoplasma in the treatment of osteoarthrosis of this technology is easy to use, does not require sophisticated equipment can take the pain, improve joint mobility, to promote processes of restoration of cartilage, bone and soft tissue of the joint, to prolong the period of remission of the disease

Towards a complex geometry manufacturing : A case study on metal 3D printing of topology optimised bicycle parts with lattices

Manufacturing metal parts with complex geometries using conventional methods has proven to be almost impossible due to tooling constraints. Additive Manufacturing (AM) or 3D printing has proven to be a solution for manufacturing such parts since the constraints imposed by traditional manufacturing are not applicable to AM. The research objective is to demonstrate the workflow from design to manufacturing complex geometry parts specifically for AM Selective Laser Melting (SLM) process, it also has its own constraints that are different than traditional manufacturing. AM provides a solution to manufacturing topology optimised complex geometries that cannot be manufactured using conventional methods. In order to demonstrate the possibilities and challenges of producing complex geometries with additive manufacturing, a case study of manufacturing topology optimised bicycle parts has been conducted at the University of Vaasa, Finland using SLM technology, based on the Powder Bed Fusion (PBF) process. The results of this research show that metal 3D printing is an enabler for manufacturing topology optimised complex geometries with challenges such as the need to edit and optimise the automatically-generated supports, and thermal solid support design for anchoring large flat surfaces, and possible boundary shells issues and post-processing planning.©2022 the Authors. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)fi=vertaisarvioitu|en=peerReviewed

Congenital Glaucoma – Case Reports

Congenital glaucoma is a rare sight threatening disease that is characterized by an autosomal-recessively inheritance. The high intraocular pressure in congenital glaucoma is due to abnormalities in the development of the anterior chamber angle and is not associated with other ocular or systemic anomalies. Typical findings are trabecular dysgenesis and glaucomatous changes of the ocular fundus. The involvement of gene mutations of GLC3A and GLC3B has already been proven to be a part  of the pathogenesis of the disease. Purpose: To present a clinical cases with proven congenital glaucoma and to analyze the outcome of treatment. Material: 7 months old male and 1 year and 5month female, admitted for a subsequent follow up in the Eye Clinic of the University Alexandrovska Hospital – Sofia. Methods: A complete ophthalmologic examination under general anesthesia, tonometry, echobiometry, gonioscopy and refraction. Results: One of the patient had unilateral glaucoma and have been operated twice with following topical therapy. The other child has bilateral disease, single surgery of both eyes and does not require additional topical medication. Both children are at risk of deprivation amblyopia. Conclusion: Congenital glaucoma is a socially significant disease because of the poor vision prognosis. More than one operation is often required, as well as maintenance conservative treatment. A lifelong monitoring of intraocular pressure and retinal nerve fiber layer is required

Normal tension glaucoma – case report

Normal tension glaucoma (NTG), reffered to also as low-tension glaucoma, represents a glaucomatous optic neuropathy classified as a type of Primary open angle glaucoma (POAG). It is characterized by a higher tendency of damage to the optic nerve at relatively low levels of intraocular pressure (IOP), as well as asymmetric pathological process in both eyes of the same patient. A number of IOP-independent factors play a significant role in the progression of the disease and often lead to difficulties in diagnosis and optimal therapy in these patients. We report a typical clinical case of a patient with NTG

Atypical suamous papilloma of the conjunctiva

Papillomas are benign tumors of human skin and mucous membranes caused by human papillomavirus (HPV). The virus causes abnormal epithelial cell growth. The formations vary in shape, size and location. The conjunctival papillomas are one of the most common benign tumors of the squamous epithelium of the conjunctiva. They rarely undergo malignant transformation. Purpose: To present a clinical case with proven atypical squamous papilloma of the conjunctiva. Materials: 58-year-old patient was admitted to the Eye Clinic of University Alexandrovska hospital for the first time. Methods: A complete ophthalmologic examination, ultrasonography, surgery and pathohistological diagnosis were performed. Results: Thorough excision of the tumor lesion in healthy tissue was performed. The pathological diagnosis revealed atypical squamous papilloma of the conjunctiva. Conclusion: The diagnosis can only be confirmed pathohistologically. A good relationship between ophthalmologist and pathologist is necessary for the successful diagnosis and subsequent treatment

Analytic Approximations for Three Neutrino Oscillation Parameters and Probabilities in Matter

The corrections to neutrino mixing parameters in the presence of matter of constant density are calculated systematically as series expansions in terms of the mass hierarchy \dm{21}/\dm{31}. The parameter mapping obtained is then used to find simple, but nevertheless accurate formulas for oscillation probabibilities in matter including CP-effects. Expressions with one to one correspondence to the vacuum case are derived, which are valid for neutrino energies above the solar resonance energy. Two applications are given to show that these results are a useful and powerful tool for analytical studies of neutrino beams passing through the Earth mantle or core: First, the ``disentanglement problem'' of matter and CP-effects in the CP-asymmetry is discussed and second, estimations of the statistical sensitivity to the CP-terms of the oscillation probabilities in neutrino factory experiments are presented.Comment: 17 pages, 3 figure

LagrangeBench: A Lagrangian Fluid Mechanics Benchmarking Suite

Machine learning has been successfully applied to grid-based PDE modeling in various scientific applications. However, learned PDE solvers based on Lagrangian particle discretizations, which are the preferred approach to problems with free surfaces or complex physics, remain largely unexplored. We present LagrangeBench, the first benchmarking suite for Lagrangian particle problems, focusing on temporal coarse-graining. In particular, our contribution is: (a) seven new fluid mechanics datasets (four in 2D and three in 3D) generated with the Smoothed Particle Hydrodynamics (SPH) method including the Taylor-Green vortex, lid-driven cavity, reverse Poiseuille flow, and dam break, each of which includes different physics like solid wall interactions or free surface, (b) efficient JAX-based API with various recent training strategies and three neighbor search routines, and (c) JAX implementation of established Graph Neural Networks (GNNs) like GNS and SEGNN with baseline results. Finally, to measure the performance of learned surrogates we go beyond established position errors and introduce physical metrics like kinetic energy MSE and Sinkhorn distance for the particle distribution. Our codebase is available at https://github.com/tumaer/lagrangebench .Comment: Accepted at 37th Conference on Neural Information Processing Systems (NeurIPS 2023) Track on Datasets and Benchmark

Capillary pressure of van der Waals liquid nanodrops

The dependence of the surface tension on a nanodrop radius is important for the new-phase formation process. It is demonstrated that the famous Tolman formula is not unique and the size-dependence of the surface tension can distinct for different systems. The analysis is based on a relationship between the surface tension and disjoining pressure in nanodrops. It is shown that the van der Waals interactions do not affect the new-phase formation thermodynamics since the effect of the disjoining pressure and size-dependent component of the surface tension cancel each other.Comment: The paper is dedicated to the 80th anniversary of A.I. Rusano