A New Probe of the Molecular Gas in Galaxies: Application to M101

Recent studies of nearby spiral galaxies suggest that photodissociation regions (PDRs) are capable of producing much of the observed HI in galaxy disks. In that case, measurements of the HI column density and the far-ultraviolet (FUV) photon flux provide a new probe of the volume density of the local underlying H_2. We develop the method and apply it to the giant Scd spiral M101 (NGC 5457). We find that, after correction for the best-estimate gradient of metallicity in the ISM of M101 and for the extinction of the ultraviolet emission, molecular gas with a narrow range of density from 30-1000 cm^-3 is found near star- forming regions at all radii in the disk of M101 out to a distance of 12' (approximately 26 kpc), close to the photometric limit of R_25 = 13.5'. In this picture, the ISM is virtually all molecular in the inner parts of M101. The strong decrease of the HI column density in the inner disk of the galaxy at R_G < 10 kpc is a consequence of a strong increase in the dust-to-gas ratio there, resulting in an increase of the H_2 formation rate on grains and a corresponding disappearance of hydrogen in its atomic form.Comment: accepted for publication in The Astrophysical Journal (1 August 2000); 29 pages including 20 figures (7 gif); AAS LaTex; contact authors for full resolution versions of gif figure

Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50 are admixtures of the human colon carcinoma cell line HCT 116

In two recently described human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50, derived from one tumour, we detected identical E-cadherin and β-catenin gene mutations as in colon carcinoma cell line HCT 116. We demonstrate by HLA-typing, mutation analysis and microsatellite analysis that cell lines JROECL 47 and JROECL 50 are admixtures of the human colon adenocarcinoma cell line HCT 116. © 2000 Cancer Research Campaig

Dust in 3C324

The results of a deep submillimetre observation using SCUBA of the powerful radio galaxy 3C324, at redshift z=1.206, are presented. At 850 microns, emission from the location of the host radio galaxy is marginally detected at the 4.2 sigma level, 3.01 +/- 0.72 mJy, but there is no detection of emission at 450 microns to a 3 sigma limit of 21 mJy. A new 32 GHz radio observation using the Effelsberg 100m telescope confirms that the sub-millimetre signal is not associated with synchrotron emission. These observations indicate that both the mass of warm dust within 3C324, and the star formation rate, lie up to an order of magnitude below the values recently determined for radio galaxies at z = 3 to 4. The results are compared with dust masses and star formation rates derived in other ways for 3C324.Comment: 5 pages LaTeX, including 1 figure. Accepted for publication in MNRA

SCUBA observations of the host galaxies of four dark gamma-ray bursts

We present the results of a search for submillimetre-luminous host galaxies of optically dark gamma-ray bursts (GRBs) using the Submillimetre Common-User Bolometer Array (SCUBA) on the James Clerk Maxwell Telescope (JCMT). We made photometry measurements of the 850-micron flux at the location of four `dark bursts', which are those with no detected optical afterglow despite rapid deep searches, and which may therefore be within galaxies containing substantial amounts of dust. We were unable to detect any individual source significantly. Our results are consistent with predictions for the host galaxy population as a whole, rather than for a subset of dusty hosts. This indicates that optically dark GRBs are not especially associated with very submillimetre-luminous galaxies and so cannot be used as reliable indicators of dust-enshrouded massive star-formation activity. Further observations are required to establish the relationship between the wider GRB host galaxy population and SCUBA galaxies.Comment: 6 pages. Accepted for publication in MNRA

Streaming Motions Towards the Supermassive Black Hole in NGC 1097

We have used GMOS-IFU and high resolution HST-ACS observations to map, in unprecedented detail, the gas velocity field and structure within the 0.7 kpc circumnuclear ring of the SBb LINER/Seyfert 1 galaxy NGC 1097. We find clear evidence of radial streaming motions associated with spiral structures leading to the unresolved (<3.5 parsecs) nucleus, which we interpret as part of the fueling chain by which gas is transported to the nuclear starburst and supermassive black hole.Comment: 4 pages, 3 figures using emulateapj. Accepted for publication in Astrophysical Journal Letters. Download high-resolution version from http://www.astro.uu.se/~kambiz/DOC/paper-N1097.pd

SCUBA Observations of the Host Galaxies of Gamma-Ray Bursts

In recent years, a population of galaxies with huge infrared luminosities and dust masses has been discovered in the submillimetre. Observations suggest that the AGN contribution to the luminosities of these submillimetre-selected galaxies is low; instead their luminosities are thought to be mainly due to strong episodes of star formation following merger events. Our current understanding of GRBs as the endpoints in the life of massive stars suggest that they will be located in such galaxies.We have observed a sample of well-located GRB host galaxies in the submillimetre. Comparing the results with the general submillimetre-selected galaxy population, we find that at low fluxes (S850 ≤ 4 mJy), the two agree well. However, there is a lack of bright GRB hosts in the submillimetre. This finding is reinforced when the results of other groups are included. Possible explanations are discussed. These results help us assess the roles of both GRB host galaxies and submillimetre-selected galaxies in the evolution of the Universe

SCUBA sub-millimeter observations of gamma-ray bursters. I. GRB 970508, 971214, 980326, 980329, 980519, 980703

We discuss the first results of our ongoing program of Target of Opportunity observations of gamma-ray bursts (GRBs) using the SCUBA instrument on the James Clerk Maxwell Telescope. We present the results for GRB 970508, 971214, 980326, 980329, 980519, and 980703. Our most important result to date is the detection of a fading counterpart to GRB 980329 at 850 microns. Although it proved to be difficult to find the infrared counterpart to this burst, the sub-millimeter flux was relatively bright. This indicates that intrinsically the brightness of this counterpart was very similar to GRB 970508. The radio through sub-millimeter spectrum of GRB 980329 is well fit by a power law with index alpha = +0.9. However, we cannot exclude a nu^(1/3) power law attenuated by synchrotron self-absorption. An alpha = +1 VLA-SCUBA power law spectrum is definitely ruled out for GRB 980703, and possibly also for GRB 980519. We cannot rule out that part of the sub-millimeter flux from GRB 980329 comes from a dusty star-forming galaxy at high redshift, such as the ones recently discovered by SCUBA. Any quiescent dust contribution will be much larger at sub-millimeter than at radio wavelengths. Both a high redshift and large dust extinction would help explain the reddening of the counterpart to GRB 980329, and a redshift of z = 5 has been suggested. The large intensity of this burst might then indicate that beaming is important.Comment: 6 pages, 3 figures, submitted to Astronomy and Astrophysic

Ifosfamide in advanced adenocarcinoma of the oesophagus or oesophageal-gastric junction area

Abstract 25 previously untreated patients with inoperable or metastatic adenocarcinoma of the oesophagus or oesophageal-gastric junction area were treated with ifosfamide 6 g/m2 over 48 hours, combined with mesna 6 g/m2. 1 complete response and 1 partial response were seen among 23 patients evaluable, with a response duration of 29+ months and 7 months, respectively. Toxicity was not severe: grade 3 infection in 2 patients, grade 3 leucopenia in 3 patients and grade 3 nausea in 4 patients. No life-threatening episodes or central nervous system toxicity were encountered. Ifosfamide has limited activity in adenocarcinoma of the oesophageal-gastric junction area

IRC+10216's Innermost Envelope -- The eSMA's View

We used the Extended Submillimeter Array (eSMA) in its most extended configuration to investigate the innermost (within a radius of 290 R* from the star) circumstellar envelope (CSE) of IRC+10216. We imaged the CSE using HCN and other molecular lines with a beam size of 0."22 x 0."46, deeply into the very inner edge (15 R*) of the envelope where the expansion velocity is only 3 km/s. The excitation mechanism of hot HCN and KCl maser lines is discussed. HCN maser components are spatially resolved for the first time on an astronomical object. We identified two discrete regions in the envelope: a region with a radius of . 15 R*, where molecular species have just formed and the gas has begun to be accelerated (region I) and a shell region (region II) with a radius of 23 R* and a thickness of 15 R*, whose expansion velocity has reached up to 13 km/s, nearly the terminal velocity of 15 km/s. The Si$^{34}$S line detected in region I shows a large expansion velocity of 16 km/s due to strong wing components, indicating that the emission may arise from a shock region in the innermost envelope. In region II, the P.A. of the most copious mass loss direction was found to be 120 +/- 10 degrees, which may correspond to the equatorial direction of the star. Region II contains a torus-like feature. These two regions may have emerged due to significant differences in the size distributions of the dust particles in the two regions.Comment: 26 pages, 8 figures, accepted for publication in The Astrophysical Journal. Please find the pdf at http://www.submm.caltech.edu/~hs/astroph/0904.0280.pdf and the ps file at http://www.submm.caltech.edu/~hs/astroph/0904.0280.p