5,050 research outputs found
Solute location in a nanoconfined liquid depends on charge distribution
Nanostructured materials that can confine liquids have attracted increasing attention for their diverse properties and potential applications. Yet, significant gaps remain in our fundamental understanding of such nanoconfined liquids. Using replica exchange molecular dynamics simulations of a nanoscale, hydroxyl-terminated silica pore system, we determine how the locations explored by a coumarin 153 (C153) solute in ethanol depend on its charge distribution, which can be changed through a charge transfer electronic excitation. The solute position change is driven by the internal energy, which favors C153 at the pore surface compared to the pore interior, but less so for the more polar, excited-state molecule. This is attributed to more favorable non-specific solvation of the large dipole moment excited-state C153 by ethanol at the expense of hydrogen-bonding with the pore. It is shown that a change in molecule location resulting from shifts in the charge distribution is a general result, though how the solute position changes will depend upon the specific system. This has important implications for interpreting measurements and designing applications of mesoporous materials
Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells
Overexpression of HER2 in estrogen receptor (ER)-positive human breast tumors has been associated with resistance to endocrine therapy. Here we investigated the effects of HER2 on expression of apoptotic pathways and modulation of tamoxifen-induced apoptosis in ER-positive MCF-7 breast cancer cells. We report that HER2 overexpression in MCF-7 cells is accompanied by up-regulation of antiapoptotic Bcl-2 and Bcl-XL proteins and suppression of tamoxifen-induced apoptosis. In addition, human tumor cell lines that are both ER positive and overexpress HER2 also express enhanced levels of Bcl-2 compared to cells that are either ER positive or overexpress HER2 alone. Our findings suggest that possible deregulation of antiapoptotic Bcl-2 and Bcl-XL may be associated with the enhanced survival of HER2-overexpressing and ER-positive breast cancer cells treated with antiestrogens
A VLA search for young protostars embedded in dense cores
Four dense cores, L1582A, L1689A, B133 and B68, classified as prestellar in
terms of the absence of detectable NIR emission, are observed at radio
wavelengths to investigate whether they nurture very young protostars. No
definite young protostars were discovered in any of the four cores observed. A
few radio sources were discovered close to the observed cores, but these are
most likely extragalactic sources or YSOs unrelated to the cores observed. In
L1582A we discovered a weak radio source near the centre of the core with radio
characteristics and offset from the peak of the submillimeter emission similar
to that of the newly discovered protostar in the core L1014, indicating a
possible protostellar nature for this source. This needs to be confirmed with
near- and/or mid-infrared observations (e.g. with Spitzer). Hence based on the
current observations we are unable to confirm unequivocally that L1582A is
starless. In L1689A a possible 4.5-sigma radio source was discovered at the
centre of the core, but needs to be confirmed with future observations. In B133
a weak radio source, possibly a protostar, was discovered at the edge of the
core on a local peak of the core submm emission, but no source was detected at
the centre of the core. Thus, B133 is probably starless, but may have a
protostar at its edge. In B68 no radio sources were discovered inside or at the
edge of the core, and thus B68 is indeed starless. Four more radio sources with
spectral indices characteristic of young protostars were discovered outside the
cores but within the extended clouds in which these cores reside. Conclusions:
We conclude that the number of cores misclassified as prestellar is probably
very small and does not significantly alter the estimated lifetime of the
prestellar phase.Comment: Accepted by A&
Limits on Radio Continuum Emission from a Sample of Candidate Contracting Starless Cores
We used the NRAO Very Large Array to search for 3.6 cm continuum emission
from embedded protostars in a sample of 8 nearby ``starless'' cores that show
spectroscopic evidence for infalling motions in molecular emission lines. We
detect a total of 13 compact sources in the eight observed fields to 5 sigma
limiting flux levels of typically 0.09 mJy. None of these sources lie within 1'
of the central positions of the cores, and they are all likely background
objects. Based on an extrapolation of the empirical correlation between the
bolometric luminosity and 3.6 cm luminosity for the youngest protostars, these
null-detections place upper limits of ~0.1 L_sun (d/140pc)^2 on the
luminosities of protostellar sources embedded within these cores. These limits,
together with the extended nature of the inward motions inferred from molecular
line mapping (Lee et al. 2001), are inconsistent with the inside-out collapse
model of singular isothermal spheres and suggest a less centrally condensed
phase of core evolution during the earliest stages of star formation.Comment: Accepted to the Astronomical Journal; 12 pages, 1 figur
Formation of Episodic Magnetically Driven Radiatively Cooled Plasma Jets in the Laboratory
We report on experiments in which magnetically driven radiatively cooled
plasma jets were produced by a 1 MA, 250 ns current pulse on the MAGPIE pulsed
power facility. The jets were driven by the pressure of a toroidal magnetic
field in a ''magnetic tower'' jet configuration. This scenario is characterized
by the formation of a magnetically collimated plasma jet on the axis of a
magnetic ''bubble'', confined by the ambient medium. The use of a radial
metallic foil instead of the radial wire arrays employed in our previous work
allows for the generation of episodic magnetic tower outflows which emerge
periodically on timescales of ~30 ns. The subsequent magnetic bubbles propagate
with velocities reaching ~300 km/s and interact with previous eruptions leading
to the formation of shocks.Comment: 6 pages, 5 figures. Accepted for publication in Astrophysics & Space
Scienc
E.P. Thompson and cultural sociology: questions of poetics, capitalism and the commons
There is currently a need for cultural sociology to readdress the work of humanistic and cultural Marxism. While more recently much of this work has been dismissed the appearance of more radical social movements and the on-going crisis of neoliberalism suggests that it still has much to tell us. In this respect, this article seeks to readdress the writing of historian E.P.Thompson arguing that his work on the class based and other social movements, poetics, critique of positivism and economic reason, utopia and work on the idea of the commons all has much to offer more contemporary scholarship. While the article recognises that the cultural Marxism of figures like Thompson can-not simply be resurrected it does continue to offer a number of critical insights lacking from other traditions within cultural sociology. By readdressing the internal complexity of Thompson’s writing the argumentative strategy of this article suggests that cultural sociology needs to move beyond more simplistic understandings of cultural Marxism and more carefully explore what it has to offer
Inner Structure of Protostellar Collapse Candidate B335 Derived from Millimeter-Wave Interferometry
We present a study of the density structure of the protostellar collapse
candidate B335 using continuum observations from the IRAM Plateau de Bure
Interferometer made at wavelengths of 1.2mm and 3.0mm. We analyze these data,
which probe spatial scales from 5000 AU to 500 AU, directly in the visibility
domain by comparison to synthetic observations constructed from models that
assume different physical conditions. This approach allows for much more
stringent constraints to be derived from the data than from analysis of images.
A single radial power law in density provides a good description of the data,
with best fit power law index p=1.65+/-0.05. Through simulations, we quantify
the sensitivity of this result to various model uncertainties, including
assumptions of temperature distribution, outer boundary, dust opacity spectral
index, and an unresolved central component. The largest uncertainty comes from
the unknown presence of a centralized point source. A point source with 1.2mm
flux of F=12+/-7 mJy reduces the density index to p=1.47+/-0.07. The remaining
sources of systematic uncertainty, the most important of which is the
temperature distribution, likely contribute a total uncertainty of < 0.2. We
therefore find strong evidence that the power law index of the density
distribution within 5000 AU is significantly less than the value at larger
radii, close to 2.0 from previous studies of dust emission and extinction.
These results conform well to the generic paradigm of isolated, low-mass star
formation which predicts a power law density index close to p=1.5 for an inner
region of gravitational free fall onto the protostar.Comment: Accepted to the Astrophysical Journal; 27 pages, 3 figure
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