79 research outputs found
Chemical composition and antigenotoxic properties of Lippia alba essential oils
The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral (33% geranial and 25% neral), geraniol (7%) and trans-β-caryophyllene (7%) for L. alba specimen COL512077, and carvone (38%), limonene (33%) and bicyclosesquiphellandrene (8%) for the other, COL512078. The genotoxicity and antigenotoxicity of EO and the compounds citral, carvone and limonene, were assayed using the SOS Chromotest in Escherichia coli. The EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene) showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds
Detecção da citotoxicidade de materiais biocompatĂveis nas linhagens celulares MRC-5, HeLa e RC-IAL
Evaluation of Toxicity Testing of 20 MEIC Chemicals on Hep-2 Cells Using Two Viability Endpoints
Preliminary evaluation of Aflatoxin M1 absorption/secretion profile on a Caco-2/TC7 clone, a human intestinal in vitro model, cultured on semi-permeable inserts
Studio in vitro con cellule caco-2 sul passaggio intestinale della Fumonisina B1 e dell'aminopentolo e ruolo della P-glicoproteina
In vitro study with Caco-2 cells on fumonisin B-1: Aminopentol intestinal passage and role of P-glycoprotein
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