195 research outputs found

    LAVA Simulations for the AIAA Sonic Boom Prediction Workshop

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    Computational simulations using the Launch Ascent and Vehicle Aerodynamics (LAVA) framework are presented for the First AIAA Sonic Boom Prediction Workshop test cases. The framework is utilized with both structured overset and unstructured meshing approaches. The three workshop test cases include an axisymmetric body, a Delta Wing-Body model, and a complete low-boom supersonic transport concept. Solution sensitivity to mesh type and sizing, and several numerical convective flux discretization choices are presented and discussed. Favorable comparison between the computational simulations and experimental data of nearand mid-field pressure signatures were obtained

    Verification and Validation Studies for the LAVA CFD Solver

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    The verification and validation of the Launch Ascent and Vehicle Aerodynamics (LAVA) computational fluid dynamics (CFD) solver is presented. A modern strategy for verification and validation is described incorporating verification tests, validation benchmarks, continuous integration and version control methods for automated testing in a collaborative development environment. The purpose of the approach is to integrate the verification and validation process into the development of the solver and improve productivity. This paper uses the Method of Manufactured Solutions (MMS) for the verification of 2D Euler equations, 3D Navier-Stokes equations as well as turbulence models. A method for systematic refinement of unstructured grids is also presented. Verification using inviscid vortex propagation and flow over a flat plate is highlighted. Simulation results using laminar and turbulent flow past a NACA 0012 airfoil and ONERA M6 wing are validated against experimental and numerical data

    Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease

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    Unconventional carrier-mediated ferromagnetism above room temperature in ion-implanted (Ga, Mn)P:C

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    Ion implantation of Mn ions into hole-doped GaP has been used to induce ferromagnetic behavior above room temperature for optimized Mn concentrations near 3 at.%. The magnetism is suppressed when the Mn dose is increased or decreased away from the 3 at.% value, or when n-type GaP substrates are used. At low temperatures the saturated moment is on the order of one Bohr magneton, and the spin wave stiffness inferred from the Bloch-law T^3/2 dependence of the magnetization provides an estimate Tc = 385K of the Curie temperature that exceeds the experimental value, Tc = 270K. The presence of ferromagnetic clusters and hysteresis to temperatures of at least 330K is attributed to disorder and proximity to a metal-insulating transition.Comment: 4 pages, 4 figures (RevTex4

    Computational Prediction of Pressure and Thermal Environments in the Flame Trench With Launch Vehicles

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    One of the key objectives for the development of the 21st Century Space Launch Com- plex is to provide the exibility needed to support evolving launch vehicles and spacecrafts with enhanced range capacity. The launch complex needs to support various proprietary and commercial vehicles with widely di erent needs. The design of a multi-purpose main ame de ector supporting many di erent launch vehicles becomes a very challenging task when considering that even small geometric changes may have a strong impact on the pressure and thermal environment. The physical and geometric complexity encountered at the launch site require the use of state-of-the-art Computational Fluid Dynamics (CFD) tools to predict the pressure and thermal environments. Due to harsh conditions encountered in the launch environment, currently available CFD methods which are frequently employed for aerodynamic and ther- mal load predictions in aerospace applications, reach their limits of validity. This paper provides an in-depth discussion on the computational and physical challenges encountered when attempting to provide a detailed description of the ow eld in the launch environ- ment. Several modeling aspects, such as viscous versus inviscid calculations, single-species versus multiple-species ow models, and calorically perfect gas versus thermally perfect gas, are discussed. The Space Shuttle and the Falcon Heavy launch vehicles are used to study di erent engine and geometric con gurations. Finally, we provide a discussion on traditional analytical tools which have been used to provide estimates on the expected pressure and thermal loads

    Abdominal venous thrombosis presenting in myeloproliferative neoplasm with JAK2 V617F mutation: a case report

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    <p>Abstract</p> <p>Introduction</p> <p>An unprovoked thombotic event in a patient is cause for further evaluation of an underlying hypercoaguable state. The investigation should include a thorough search, including checking for a variety of known inherited and acquired hypercoaguble states (protein C or S deficiency, anti-phospholipid antibodies, and anti-thrombin III deficiency) and gene mutations that predispose patients to an increased risk of clotting (for example, prothrombin gene 20210 mutation, factor V Leiden, and the <it>JAK2 V617F </it>mutation).</p> <p>Case presentation</p> <p>We report the case of a 38-year-old Caucasian woman with spontaneous, unprovoked abdominal venous thrombosis and demonstrate how testing for the <it>JAK2 V617F </it>mutation was useful in unmasking an underlying hypercoaguable state.</p> <p>Conclusions</p> <p><it>JAK2 V617F</it>-positive myeloproliferative neoplasm was diagnosed. This case illustrates the importance of testing for <it>JAK2 V617F </it>in patients presenting with Budd-Chiari syndrome, even in the absence of overt hematologic abnormalities, in order to establish a diagnosis of underlying myeloproliferative neoplasm.</p
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