\u201cWoulda, coulda, shoulda\u201d. Workers\u2019 proactivity in the association between emotional demands and mental health

The present study aimed to explore the mediating role of hostile customer relations in the association between emotional dissonance and workers\u2019 mental health. Moreover, the moderating role of proactive personality as a buffer against hostile customer relations was assessed. Emotional demands become crucial within professions that involve a direct relationship with clients and, if poorly managed, can negatively affect workers\u2019 health and performance. Accordingly, data were collected on a sample of n = 918 mass-retail employees working for one of the leading Italian supermarket companies. Most participants were women (62.7%) with a mean age = 40.38 (SD = 7.68). The results of a moderated mediation analysis revealed that emotional dissonance was related to more hostile customer relations that, in turn, were associated with higher rates of mental health symptoms. Proactive personality emerged as a protecting factor that prevented the onset of conflicts with clients, particularly among workers experiencing high levels of emotional dissonance. The identification of resources enabling management of emotional demands could suggest suitable adaptive strategies for customer-facing roles, thus preventing the occurrence of adverse mental health symptoms

Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I

Beta hemoglobinopathies are widely spread monogenic lethal diseases. Delta-globin gene activation has been proposed as a possible approach for curing these pathologies. The therapeutic potential of delta-globin, the non-alpha component of Hemoglobin A2 (α2δ2; HbA2), has been demonstrated in a mouse model of beta thalassemia, while its anti-sickling effect, comparable to that of gamma globin, was established some time ago. Here we show that the delta-globin mRNA level is considerably increased in a Deoxyribonuclease II-alpha knockout mouse model in which type 1 interferon (interferon beta, IFNb) is activated. IFNb activation in the fetal liver improves the delta-globin mRNA level, while the beta-globin mRNA level is significantly reduced. In addition, we show that HbA2 is significantly increased in patients with multiple sclerosis under type 1 interferon treatment. Our results represent a proof of principle that delta-globin expression can be enhanced through the use of molecules. This observation is potentially interesting in view of a pharmacological approach able to increase the HbA2 level

Air- and water-stable and photocatalytically active germanium-based 2D perovskites by organic spacer engineering

There is increasing interest in the role of metal halide perovskites for heterogeneous catalysis. Here, we report a Ge-based 2D perovskite material that shows intrinsic water stability realized through organic cation engineering. Incorporating 4-phenylbenzilammonium (PhBz) we demonstrate, by means of extended experimental and computational results, that PhBz2GeBr4 and PhBz2GeI4 can achieve relevant air and water stability. The creation of composites embedding graphitic carbon nitride (g-C3N4) allows a proof of concept for light-induced hydrogen evolution in an aqueous environment by 2D Ge-based perovskites thanks to the effective charge transfer at the heterojunction between the two semiconductors

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy

<p>Abstract</p> <p>Background</p> <p>Lipoic acid (LA), a potent antioxidant, has been used as a dietary supplement to prevent and treat many diseases, including stroke, diabetes, neurodegenerative and hepatic disorders. Recently, potent anti-tumorigenic effects induced by LA were also reported and evident as assayed by suppression of cell proliferation and induction of apoptosis in malignant cells. However, the mechanism by which LA elicits its chemopreventive effects remains unclear.</p> <p>Methods and Results</p> <p>Herein, we investigated whether LA elicits its anti-tumor effects by inducing cell cycle arrest and cell death in human promyelocytic HL-60 cells. The results showed that LA inhibits both cell growth and viability in a time- and dose-dependent manner. Disruption of the G₁/S and G₂/M phases of cell cycle progression accompanied by the induction of apoptosis was also observed following LA treatment. Cell cycle arrest by LA was correlated with dose-dependent down regulation of Rb phosphorylation, likely via suppression of E2F-dependent cell cycle progression with an accompanying inhibition of cyclin E/cdk2 and cyclin B1/cdk1 levels. Evidence supporting the induction of apoptosis by LA was based on the appearance of sub-G₁peak in flow cytometry analysis and the cleavage of poly(ADP-ribose) polymerase (PARP) from its native 112-kDa form to the 89-kDa truncated product in immunoblot assays. Apoptosis elicited by LA was preceded by diminution in the expression of anti-apoptotic protein bcl-2 and increased expression of apoptogenic protein bax, and also the release and translocation of apoptosis inducing factor AIF and cytochrome c from the mitochondria to the nucleus, without altering the subcellular distribution of the caspases.</p> <p>Conclusion</p> <p>This study provides evidence that LA induces multiple cell cycle checkpoint arrest and caspase-independent cell death in HL-60 cells, in support of its efficacious potential as a chemopreventive agent.</p

Fluctuating asymmetry as biomarker of pesticides exposure in the Italian wall lizards (Podarcis siculus)

The extensive use of pesticides in agricultural environments produces drastic effects on wildlife, hence the need for less invasive indicators of environmental stress to monitoring the impact of agriculture treatments on biological systems. Fluctuating asymmetry (FA), as measure of developmental instability, has recently been proposed as reliable biomarker of populations stress due to environmental disturbance. We investigate femoral pores (FP) and dorsal head shape (HS) traits in populations of the Italian wall lizard inhabiting agricultural environments to examine whether different pesticide exposures (conventional, organic and control) can cause distinctive degree of FA. High-resolution photographs of FP and HS were taken in the field with a digital camera. The number of FP were counted twice on both sides and HS was analysed using geometric morphometrics with 25 landmarks and 12 semilandmarks. Individuals under conventional management showed higher levels of FA compared to control ones, and females exhibited higher FA levels than males for the FP. However, no significant difference was found for the HS trait. Our study provided evidence that FA may have a real potential as biomarker of population stress in wall lizards, highlighting the importance in the choice of the experimental design and the traits adopted for estimating DI

Linking agricultural practices to lizard trophic behaviour: An ecological approach

: Among intensive agricultural practices, pesticides, mowing, and heavy agricultural machineries have become an important tool to maximize harvesting and secure animal husbandry. However, they are also cause of agricultural ecosystem decline, often leading to degradation of key micro-habitat features for many species, higher predation risk and lower food availability. We investigated the diet and foraging ecology of the Italian wall lizard in agricultural areas to determine whether different management practices (conventional, organic, and control) can affect (i) the structure of the trophic niche of the species; (ii) prey diversity, the degree of individual specialization, and the overall population feeding strategy; (iii) lizards' health status. Faecal pellets were collected for diet composition analyses, while prey diversity in the environment was estimated by placing adhesive traps. Lizards' body condition did not differ among management type although males from control field resulted slightly larger than those from conventional and organic areas. The species showed a generalist (conventional and organic areas) and mixed (control area) feeding strategy with a preference for coleopterans. Although a different prey diversity was found in control areas compared to organic and conventional ones, diet composition and the importance of specific food items was similar among management types. This may suggest that management activities may have affected the overall prey availability and indirectly influenced lizard trophic behaviour. Our study provides a comprehensive knowledge on the feeding ecology of P. siculus in managed habitats, which may have useful implications for the overall conservation of lizards in agricultural environments

Prevenzione dello stress lavoro correlato: validazione di uno strumento per la valutazione dei rischi psicosociali nella scuola

Il presente lavoro ha l’obiettivo di presentare lo strumento Questionario sul Benessere a Scuola (QBS) e la relativa validazione. Il questionario è finalizzato alla valutazione dei rischi psicosociali e alla promozione del benessere organizzativo nella scuola. Partendo dall’analisi della letteratura e della normativa di riferimento e grazie al contributo di esperti del settore è stato predisposto un questionario per individuare i fattori di rischio psicosociale relativi al contesto e al contenuto lavorativo. Hanno risposto al questionario 953 persone che lavorano all’interno della scuola (82% docenti). I risultati mostrano la validità e l’attendibilità dello strumento proposto per valutare i fattori di rischio psicosociale nella scuola, segnalandone un possibile uso nella valutazione dello stress lavoro correlato. Gli stessi fattori permettono inoltre di discriminare diversi tipi di esiti (benessere, fatica mentale, ecc.). I risultati possono, quindi, essere considerati una conferma di quanto richiamato dalla normativa attuale in materia di sicurezza sul lavoro rispetto ai potenziali effetti delle caratteristiche del lavoro e dell’organizzazione del lavoro sulla salute dei lavoratori