15 research outputs found
Adult Laryngeal Rhabdomyosarcoma: Report of a Case and Literature Review
Rhabdomyosarcoma is relatively seen in the pediatric age group with the
head and neck region as the commonest site. To the best of our
knowledge, few cases of laryngeal involvement in adult have been
described in the literature. Biologically, rhabdomyosarcoma is
different from squamous cell carcinoma, which is the commonest tumor of
the larynx. A previously healthy non-smoker 77-year-old lady presented
to the ENT outpatient with a six weeks history of intermittent
alteration of voice quality. She had no history of sore throat, or any
symptoms suggesting laryngo-pharyngeal reflux. Examination showed
asymmetry of the left arytenoid cartilage and aryepiglottic fold. She
subsequently had a direct laryngoscopy and biopsy. Histology and
immunohistochemistry examination suggested the diagnosis of mesenchymal
neoplasm. Following discussion at MDT she subsequently had a total
laryngectomy. Histology confirmed a completely excised laryngeal
rhabdomyosarcoma. Rhabdomyosarcoma of larynx in adult is a rare
disease. Surgical treatment with or without adjuvant radiotherapy is
currently the treatment of choice for this disease.Le Rhabdomyosarcome est relativement connu dans le groupe d'\ue2ge
p\ue9diatrique et les r\ue9gions les plus touch\ue9es sont la
t\ueate et le cou. A notre connaissance, peu de cas de l'implication
du larynx chez des adultes ont \ue9t\ue9 cit\ue9s dans la
litt\ue9rature. Biologiquement, rhabdomyosarcome est diff\ue9rent
de la cellule squameuse carcinome, qui est la tumeur de larynx la plus
ordinaire. Une femme non-fumeuse, \ue2g\ue9e de 77 ans d'une
tr\ue8s bonne sant\ue9 au d\ue9part, s'est pr\ue9sent\ue9e
\ue0 l'ORL ambulatoire avec une p\ue9riode de six semaines
histoires de l'alt\ue9ration r\ue9p\ue9t\ue9e de la
qualit\ue9 de la voix. Elle n'avait pas d'ant\ue9c\ue9dente de
maux de gorge ou aucun sympt\uf4mes suggestifs le reflux
laryngo-pharyngien. L'examen a montr\ue9 l'asym\ue9trie de la
gauche aryt\ue9no\uefde cartilage aryepiglottique pli. Elle a par
la suite eu une laryngoscopie directe et la biopsie. L'examen
histologique et immunohistochimie a sugg\ue9r\ue9 le diagnostique
des tumeurs mesenchymteuses, n\ue9oplasme. A la suite d'une
discussion au MDT elle a ensuite eu une laryngectomie totale.
L'histologie a confirm\ue9 une excis\ue9e larynx chez des adultes
qui est une maladie rare. Le traitement chirurgical avec ou sans
radioth\ue9rapie adjuvante est actuellement le traitement du choix
pour cette maladie
Laryngeal embryonal rhabdomyosarcoma in an adult - A case presentation in the eyes of geneticists and clinicians
<p>1. Abstract</p> <p>Background</p> <p>Rhabdomyosarcoma is a solid tumor, resulting from dysregulation of the skeletal myogenesis program. For rhabdomyosarcomas (RMS) with a predilection for the head and neck, genitourinary tract, extremities, trunk, retroperitoneum, the larynx is still an unusual site. Till now only several cases of this laryngeal tumor have been described in world literature in the adult population. The entire spectrum of genetic factors underlying RMS development and progression is unclear until today. Multiple signaling pathways seem to be involved in ERMS development and progression.</p> <p>Case presentation</p> <p>In this paper we report an interesting RMS case in which the disease was located within the glottic region. We report an embryonal rhabdomyosarcoma of the larynx in 33 year-old man. After unsuccessful chemotherapy hemilaryngectomy was performed. In follow up CT no signs of recurrence were found. Recently patient is recurrence free for 62 months.</p> <p>Conclusions</p> <p>Considering the histological diagnosis and the highly aggressive nature of the lesion for optimal diagnosis positron electron tomography (PET) and computerized tomography (CT) of the neck and thorax should be performed. At this time surgical treatment with adjuvant radiotherapy seems to be the treatment of choice for this disease. Rhabdomyosarcoma of the larynx has a better prognosis than elsewhere in the body, probably because of its earlier recognition and accessibility to radical surgery.</p
Dysplastic bone disease mimicking exostoses of the ear canal
No abstract available
Adult Laryngeal Rhabdomyosarcoma: Report of a Case and Literature Review
Rhabdomyosarcoma is relatively seen in the pediatric age group with the
head and neck region as the commonest site. To the best of our
knowledge, few cases of laryngeal involvement in adult have been
described in the literature. Biologically, rhabdomyosarcoma is
different from squamous cell carcinoma, which is the commonest tumor of
the larynx. A previously healthy non-smoker 77-year-old lady presented
to the ENT outpatient with a six weeks history of intermittent
alteration of voice quality. She had no history of sore throat, or any
symptoms suggesting laryngo-pharyngeal reflux. Examination showed
asymmetry of the left arytenoid cartilage and aryepiglottic fold. She
subsequently had a direct laryngoscopy and biopsy. Histology and
immunohistochemistry examination suggested the diagnosis of mesenchymal
neoplasm. Following discussion at MDT she subsequently had a total
laryngectomy. Histology confirmed a completely excised laryngeal
rhabdomyosarcoma. Rhabdomyosarcoma of larynx in adult is a rare
disease. Surgical treatment with or without adjuvant radiotherapy is
currently the treatment of choice for this disease.Le Rhabdomyosarcome est relativement connu dans le groupe d'âge
pédiatrique et les régions les plus touchées sont la
tĂŞte et le cou. A notre connaissance, peu de cas de l'implication
du larynx chez des adultes ont été cités dans la
littérature. Biologiquement, rhabdomyosarcome est différent
de la cellule squameuse carcinome, qui est la tumeur de larynx la plus
ordinaire. Une femme non-fumeuse, âgée de 77 ans d'une
très bonne santé au départ, s'est présentée
à l'ORL ambulatoire avec une période de six semaines
histoires de l'altération répétée de la
qualité de la voix. Elle n'avait pas d'antécédente de
maux de gorge ou aucun symptĂ´mes suggestifs le reflux
laryngo-pharyngien. L'examen a montré l'asymétrie de la
gauche aryténoïde cartilage aryepiglottique pli. Elle a par
la suite eu une laryngoscopie directe et la biopsie. L'examen
histologique et immunohistochimie a suggéré le diagnostique
des tumeurs mesenchymteuses, néoplasme. A la suite d'une
discussion au MDT elle a ensuite eu une laryngectomie totale.
L'histologie a confirmé une excisée larynx chez des adultes
qui est une maladie rare. Le traitement chirurgical avec ou sans
radiothérapie adjuvante est actuellement le traitement du choix
pour cette maladie