A Clinical Study on Ocular Motor Nerve Palsies following Trauma

INTRODUCTION: The term “Ocular motor system” refers to the entire somatic motor system which controls the position and movements of the eyes. It includes extraocular muscles, the cranial nerves and their nuclei that innervate them and the forces that stimulate and inhibit their actions. “Ocular motor nerves” refers to third (Oculomotor), fourth (Trochlear) and sixth (Abducent) cranial nerves. Superior rectus, medial rectus, inferior rectus, inferior oblique, levator palpebrae superioris and the intrinsic muscles of the eye are supplied by the Oculomotor nerve. Superior oblique is supplied by the Trochlear nerve. Lateral rectus is supplied by the Abducent nerve1. Ocular motor nerves control the extra ocular movements of the eyes. Restricted ocular mobility can occur as the result of paralysis of the nerves supplying the extra ocular muscles or due to the pathology in the muscle itself or there may be the pathology at the myoneural junction. AIM OF THE STUDY: The aim of the study is to study the clinical profile of ocular motor nerve palsies following trauma, the mode of injury, the most commonly involved nerve palsy following trauma and to assess the recovery of post traumatic nerve palsy. MATERIALS AND METHODS: The cases studied included those patients with neurogenic motor nerve palsies who presented to RIOGOH, Egmore, Chennai for a period of One year, March 2018 - February 2019. They were registered, evaluated and followed up during the study period. RESULTS: Out of the 40 cases studied, the age group ranged from 17-68 years, 52.5% of cases were in the age group of 31-50 years .The mean age of presentation of third,fourth and sixth nerve was 47.0,38.0 and 37.92 respectively. Third nerve palsies occurred in a wide range of age group.There was a preponderance in males (62.5%) than in females(37.5%) in all ocular motor nerve palsies. In the study RTA was most common cause of ocular motor nerve palsy in 40% of the patients. Ocular trauma caused about 15% cases of ocular motor nerve palsy. The most common nerve involved in trauma is the oculomotor nerve(40%), followed by VI nerve(32.5%), III, IV, VI nerves(15%), IV nerve(7.5%) respectively.In 55% of patients neuroimaging was normal. Traumatic nerve palsies had full recovery in 57.5% of patients. Partial recovery in 25% of patients. 12.5% were not recovered at the end of the study. In this study, 43.75% of patients with third nerve palsy had full recovery, whereas 31.25% of patients had partial recovery and 12.5% of patients did not recover. 2 patients had aberrant regeneration. CONCLUSION: Cranial nerves can be injured before, during or after their passage through the skull. Closed head injury even trivial is associated with trochlear nerve palsies while forcible head trauma as in cases of RTA can lead to III & VI cranial nerve palsies. Careful examination and history taking of the patient is necessary. Radiological investigations should be carried out.,The imaging abnormalities may not correlate with a particular cranial nerve injury. Long term follow up of the patient is necessary

PHYSIOCHEMICAL INVESTIGATION AND BIOVALUATION OF TiO2 NANOCRYSTALS SYNTHESIZED BY CHEMICAL AND GREEN ROUTE

Objectives: In this present work, we have compared titanium dioxide nanocrystals synthesized by both chemical method and biological method from Titanium tetra isopropoxide as precursor. The biological method was performed by using the aqueous root extract of Desmodium gangeticum and further they were characterized and checked for their biological activities. Methods: The TiO2 nanocrystals were characterized by UV-Visible spectrophotometer for its maximum SPR peak, X-ray diffractometry for its crystalline size and shape, Fourier transform infrared spectroscopy for functional entity identification and Zeta potential for its colloidal stability. Antioxidant assay and antimicrobial test were performed to evaluate its biological behaviour. Results: The nanocrystals synthesized by biological method were found to have higher antioxidant potential, antimicrobial activity and phenolic content than the chemically synthesized ones. Evaluation of toxicity in cell line LLC-PK1 suggests that TiO2nanocrystals synthesized by green route is less toxic. Conclusion: Green synthesized TiO2 nanocrystals were seen to have less toxicity than the chemical method in showing their biocompatibility nature which can be applied in the field of medical science

DESMODIUM GANGETICUM ROOT AQUEOUS EXTRACT MEDIATED SYNTHESIS OF NI NANOPARTICLE AND ITS BIOLOGICAL EVALUATION

Objective: A novel, eco-friendly method of Nickel nanoparticles synthesis using aqueous extract of Desmodium gangeticum root (DG) has been reported in this study.Methods: Novel approach on synthesis of Ni nanoparticles using NiCl2 as precursor and aqueous extract of Desmodium gangeticum root as the reducing agent. Nanoparticles were characterized for its average size, morphology, functional moieties and thermal stability by UV-Visible spectrophotometry, X-Ray Diffractometry (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared spectroscopy (FTIR) and Thermo Gravimetric Analysis (TGA) respectively. Cytotoxicity was also determined against LLC PK1 cell lines using LDH assay.Results: Less aggregate spherical shaped and mono-dispersed nanoparticles were synthesised whose size ranges from 20-30 nm in diameter. Nanoparticles were exhibit face centre cubic crystalline phase with an average size of ~23 nm which was obtained from XRD spectral pattern. Strong interaction between Desmodium gangeticum and nanoparticles was shown in TGA-thermogram. The reducing potential and total phenolic content of Ni nanoparticles was found to be same as that of Desmodium gangeticum. All the results were expressed as mean±SD of n = 4-6 independent assays, p<0.05, whose data were analysed using ANOVA.Conclusion: Biological activity of the nanoparticles and its toxicity was assessed and found to possess the good antioxidant and reduction potential with significant antibacterial activity and were nontoxic.Â

Does sentence structure boost early word learning?:An artifical language learning study

This paper examines the semantic consequences of the presence and absence of the verbal particle in Hungarian sentences containing a verb of creation. Since these verbs are Definiteness-Effect verbs, the aspectual interpretation does not depend merely on the verbal particle’s position – or even presence – in the sentence, as in other cases, but rather on the specific/non-specific interpretation of the object. The main claim of the paper is that the verbal particle’s role in such sentences can be defined in terms of collectivity and distributivity: the Definiteness-Effect constructions – the ones without verbal particle – can only refer to collective events, and the non-Definiteness-Effect-constructions – the ones containing a verbal particle – can refer to both collective and distributive events

ELECTROCEUTICALS: AN ALTERNATE BLESSING TO MANKIND

ABSTRACTThe objective of the present study is to understand the use of electricity in treating ailments to mankind where they need not swallow the pills or injectintravenously rather have the device implanted which would monitor the nerve impulses, detect if any problems exist, and then supply electricity tothe organs affected to make them function properly. This study is based on the case approach to identify the usefulness of electrical appliances formankind. Each individual is unique and, therefore, electroceutical devices should also have the patient-specific element for smarter use of the implant.This newly emerging field of electroceuticals needs to be understood keeping in mind the body's electrical grid and the language of nerve impulsesto treat varied diseases and disorders affecting the mankind. The study pinpointed that electroceuticals is supplements to traditional treatment.Although much usefulness is found toward using electrical impulses to treat the organ, the devices need to be designed with relatively small wiresand batteries for easier implantation. Each individual is unique and, therefore, electroceutical devices should also have the patient-specific elementfor smarter use of the implant.Keywords: Electroceuticals, Ailments, Electrical appliances, Patient-specific treatment

Methyl 3-[(E,E)-3-phenyl­prop-2-enyl­idene]dithio­carbazate

In the title compound, C11H12N2S2, the dithio­carbazate group adopts an EE configuration with respect to the C=C and C=N bonds of the propenyl­idene group. The atoms of the propenyl­idene and dithio­carbazate unit are essentially co-planar, with a maximum deviation of 0.058 (1) Å; the phenyl ring forms a dihedral angle of 18.3 (1)° with this fragment. In the crystal, mol­ecules form inversion dimers via pairs of N—H⋯S hydrogen bonds involving the terminal S atom

Radionuclides (40K, 232Th and 238U) and Heavy Metals (Cr, Ni, Cu, Zn, As and Pb) Distribution Assessment at Renggam Landfill, Simpang Renggam, Johor, Malaysia

The assessment of radioactivity levels and the distribution of heavy metals in soil samples at CEP Farm landfill, Renggam in Johor State was to determine the activity concentrations of naturally occurring radionuclides and heavy metal concentrations of this landfill. The background radiation was monitored to estimate the exposure level. The activity concentrations of radionuclides in soil samples were determined using HPGe gamma ray spectroscopy whereas the heavy metal concentration was measured using X-RF analysis. The mean exposure rate at the landfill site was 36.2±2.4 μR hr-1 and the annual effective dose rate at the landfill site was 3.19 ± 0.22 mSv yr-1. However, residential area has lower mean exposure dose rate of about 16.33±0.72 μR hr-1 and has an annual effective dose rate of 1.43±0.06 mSv yr-1 compared to landfill sites. The mean activity concentration of 40K, 238U and 232Th at landfill site were 239.95±15.89 Bq kg-1, 20.90±2.49 Bq kg-1 and 40.61±4.59 Bq kg-1, respectively. For heavy metal compositions, Cr, Ni and Cu have mean concentration of 232±10 ppm, 23±2 ppm, and 46±19 ppm, respectively. Whereas, Zn has concentration of 64±9 ppm and concentration of 12±1 ppm and 71±2 ppm was estimated for As and Pb respectively. The higher activity concentration of 40K down the slope through leaching process whereas the higher activity level of 238U content at the landfill site may be attributed to the soil disruption to local equilibriu

Semi-monthly effect in stock returns: new evidence from Bombay Stock Exchange

Semi-monthly effect is a kind of calendar anomalies which is less explored in the financial literature. The main objective of this paper to investigate the presence of semi-monthly effect in selected sectoral indices of Bombay Stock Exchange (BSE). The study uses the daily stock returns of five sectoral indices viz S&P BSE Auto Index, S&P BSE Bankex, S&P BSE Consumer Durables Index, S&P BSE FMCG Index and S&P BSE Health Care Index for the period of 10 years starting from 1st April 2007 to 31st March 2017. The data were analyzed using two approaches namely calendar days approach and trading days approach. To test the equality of mean returns for the two halves of the month, Mann-Whitney U test is used. The empirical results of the study did not provide any evidence for the presence of semi-monthly effect in the selected sectoral indices. Nevertheless, BSE Auto Index showed significant difference in the mean returns of first half and second half of trading month during the study period

Key distinguishing characters (KDCs) of official (Boerhaavia diffusa L.) and commonly mistaken (Trianthema portulacastrum L.) sources of Mukkirattai of Siddha

Boerhaavia diffusa L. has been used extensively in Siddha system of medicine and is often confused with Trianthema portulacastrum L. due to morphological similarities. This particular study compares, analyses and identifies the key distinguishing features of the two whole plant drugs based on pharmacognostical and phytochemical aspects. The samples were studied for macroscopy, microscopy, physicochemical analysis, preliminary phytochemical analysis and HPTLC following standard procedures. Macroscopic studies showed few notable differences in macro-microscopy of root, stem, leaves and flowers of both the plants. Microscopically root, stem, leaf and petiole of both the plants showed differences in layers of cork, presence of crystals and medullary rays (in root), the thickness of cuticle, cortex and arrangement of vascular bundles (stem), presence of characteristic type of trichomes (leaf) and shape of the petiole. Powder microscopy showed differences in epidermis, crystal types and shape of pollen. Preliminary phytochemical analysis showed the presence of phenol, saponins and coumarins in B. diffusa and was not detected in T. portulacastrum. There were significant differences in the values of quantitative microscopy, physicochemical parameters and HPTLC of both the whole plant samples. The finding of this study will be helpful for the correct identification of the plant