Optimal design and operation of a biogas fuelled MCFC (molten carbonate fuel cells) system integrated with an anaerobic digester

In this paper, a biogas fuelled hybrid system, obtained by integrating a molten carbonate fuel cell with a micro-turbine is considered. The size of the plant is selected on the basis of the maximum biogas production registered by monitoring the annual operation of an anaerobic digestion plant. The system produces electricity and supplies heat to the digester. Heat is necessary to keep correct operating temperature of the bacteria. A model of the system components is built and the plant optimization is performed. Design parameters are the fuel cell temperature, pressure ratio, inlet turbine temperature, reforming temperature, recirculation percentage, size of the two subsystems. Two competing objective functions are considered: the energy efficiency and the unit cost of electricity. The Pareto front shows that efficiencies close to 50% are obtained, with unit costs comparable with market prices of electricity. The off-design conditions caused by variations in biogas production and thermal request of the digester are also considered. Experimental data from the digester are used to investigate these variations. The optimal operation is selected depending on the daily heat request and biogas production. Possible economic and energy benefits that can be achieved by adding natural gas are also investigated

Impact of district heating and groundwater heat pump systems on the primaryenergy needs in urban areas

This work is focused on the planning of rational heating systems for urban areas. From the sustainability viewpoint, district heating is an important option to supply heat to the users in urban areas. The energy convenience of such option depends on the annual energy request, the population density and the efficiency in heat production. Among the alternative technologies, geothermal heat pumps (both open loop and closed loop heat pumps) play a crucial role. This paper aims to propose a procedure to select which users in an urban area should be connected with a district heating network and which ones should be heated through an alternative technology, in order to reach a globally optimal system from the energy viewpoint. The procedure proposes district heating as the initial choice for all the users. The users are then progressively disconnected to the network, according with the primary energy required to supply them heat, and the alternative technology is considered for disconnected users. Here, ground water heat pump is considered as the alternative technology. The total primary energy request is assumed as the objective function to be minimized. To reach this result, the exergetic cost of heat supplied through heat pumps system must be evaluated. Such evaluation is not trivial, as it must include proper analysis of both the district heating network and the alternative system. In the case of densely populated areas, an additional consideration is necessary: the subsurface thermal degradation caused by heat pump installations may affect the performances of surrounding installations. This impact is calculated through a thermo-fluid dynamic model of the subsurface. The application to an Italian town is considered as a test case. The optimal configuration of the overall urban heating system is obtained. This configuration corresponds to the minimum primary energy request to supply heat to all the users (those connected to the network and those using an alternative heating system)

Analysis of Dense Gas Effects in Compressible Turbulent Channel Flows

In this work we investigate the influence of dense gas effects on compressible wall-bounded turbulence. Turbulent flows of dense gases represent a research field of great importance for a wide range of applications in engineering. Dense gases are single-phase fluids with a molecular complexity such that the fundamental derivative of gas dynamics [1], which measures the rate of change of the sound speed in isentropic transformations, is less than one in a range of thermodynamic conditions close to the saturation curve. In such conditions, the speed of sound increases in isentropic expansions and decreases in isentropic compressions, unlike the case of perfect gases. For dense gases, the perfect gas model is no longer valid, and more complex equations of state must be used to account for their peculiar thermodynamic behavior. Moreover, in the dense gas regime, the dynamic viscosity μ and the thermal conductivity λ depend on temperature and pressure through complex relationships. Similarly, the approximation of nearly constant Prandtl number Pr= μ c p / λ is no longer valid. Numerical simulations of turbulent dense gas flows of engineering interest are based on the (Reynolds-Averaged Navier–Stokes) RANS equations, which need to be supplemented by a model for the Reynolds stress tensor and turbulent heat flux. The accuracy of RANS models for dense-gas flows has not been properly assessed up to date, due to the lack of both experimental and numerical reference data. DNS databases [2, 3] are then needed to quantify the deficiencies of existing turbulence models and to develop and calibrate improved ones. In this work we first summarize some recent direct numerical simulation (DNS) results [4] for supersonic turbulent channel flows (TCF) of PP11, a heavy fluorocarbon representative of dense gases, at various bulk Mach and Reynolds numbers. The most relevant effects are represented by non-conventional variations of the fluctuating thermodynamic quantities, compared to perfect gases and a strong decoupling between thermal and dynamic effects almost everywhere in the flow, except in the immediate vicinity of the solid wall. Preliminary considerations about the validity of some currently-used models for the turbulent stresses and heat flux are carried out based on a priori comparisons between the exact terms computed from the DNS and their modeled counterparts

CSP plants with thermocline thermal energy storage and integrated steam generator – Techno-economic modeling and design optimization

Although CSP has reached technological maturity, high capital investment and specific electricity cost remain the major development barriers. To reduce them, highly efficient, integrated, and cheaper CSP components are urgently needed. In this paper, we investigate a novel CSP plant configuration with a single-tank Thermal Energy Storage (TES) fully integrated with the steam generator. The objective of this research is twofold: i) provide a reliable model of single-tank thermal storages with integrated steam generator; ii) identify two optimized CSP plant designs to achieve best energetic and economic performances. To achieve these aims we developed a numerical model of the main system components and validated it against experimental data. This model was then integrated in a full simulation and heuristic design optimization of the plant. The results revealed that the system proposed can generate electricity in middle-Italy (Rome) at a cost of 230.25 $/MWh with a 15% reduction compared to the double tank option. Furthermore, if cogeneration is used to recover the waste heat, this system is an interesting option for users such as small districts, university campuses and hospitals. In the latter case, the optimized system pays off in 6 years and covers 80% of the heating and cooling requirements

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are still unclear. Here, we used mouse and human cell lines to assess mitochondrial function of FH-deficient cells. We found that human and mouse FH-deficient cells exhibit decreased respiration, accompanied by a varying degree of dysfunction of respiratory chain (RC) complex I and II. Moreover, we show that fumarate induces succination of key components of the iron-sulfur cluster biogenesis family of proteins, leading to defects in the biogenesis of iron-sulfur clusters that affect complex I function. We also demonstrate that suppression of complex II activity is caused by product inhibition due to fumarate accumulation. Overall, our work provides evidence that the loss of a single TCA cycle enzyme is sufficient to cause combined RC activity dysfunction

Basal and one-month differed neutrophil, lymphocyte and platelet values and their ratios strongly predict the efficacy of checkpoint inhibitors immunotherapy in patients with advanced BRAF wild-type melanoma

Background To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocytes ratio, PLR) in predicting the response to immune checkpoint inhibitors (ICI) in metastatic melanoma (MM). Methods We performed a retrospective study of 272 BRAF wild-type MM patients treated with first line ICI. Bivariable analysis was used to correlate patient/tumor characteristics with clinical outcomes. Variations between time 1 and time 0 (Delta) of blood parameters were also calculated and dichotomized using cut-off values assessed by ROC curve. Results At baseline, higher neutrophils and NLR negatively correlated with PFS, OS and disease control rate (DCR). Higher PLR was also associated with worse OS. In multivariable analysis, neutrophils (p = 0.003), WBC (p = 0.069) and LDH (p = 0.07) maintained their impact on PFS, while OS was affected by LDH (p < 0.001), neutrophils (p < 0.001) and PLR (p = 0.022), while DCR by LDH (p = 0.03) and neutrophils (p = 0.004). In the longitudinal analysis, PFS negatively correlated with higher Delta platelets (p = 0.039), Delta WBC (p < 0.001), and Delta neutrophils (p = 0.020), and with lower Delta lymphocytes (p < 0.001). Moreover, higher Delta NLR and Delta PLR identified patients with worse PFS, OS and DCR. In the multivariable model, only Delta NLR influenced PFS (p = 0.004), while OS resulted affected by higher Delta WBC (p < 0.001) and lower Delta lymphocytes (p = 0.038). Higher Delta WBC also affected the DCR (p = 0.003). When clustering patients in 4 categories using basal LDH and Delta NLR, normal LDH/lower Delta NLR showed a higher PFS than high LDH/higher Delta NLR (20 vs 5 months). Moreover, normal LDH/higher Delta lymphocytes had a higher OS than high LDH/lower Delta lymphocytes (50 vs. 10 months). Conclusions Baseline and early variations of blood cells, together with basal LDH, strongly predict the efficacy of ICI in MM. Our findings propose simple, inexpensive biomarkers for a better selection of patient treatments. Prospective multicenter studies are warranted to confirm these data. © 2022, The Author(s)

A Case of Paediatric Sudden Visual Loss

Optic neuromyelitis (NMO) is a demienilizing disease traditionally characterized by optic neuritis and transverse myelitis..

Seventh Cranial Nerve Palsy: The First Sign of Multiple Sclerosis in A Young Children

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system characterized pathologically by demyelination and subsequent axonal degeneration..