54 research outputs found
The Tumor Microenvironment: The Making of a Paradigm
What has been will be again, what has been done will be done again; there is nothing new under the su
Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors
Methyllycaconitine‐ and scopolamine‐induced cognitive dysfunction: differential reversal effect by cognition‐enhancing drugs
Polyadenosine diphosphate-ribose polymerase (PARP) inhibition as a means of protecting the inner ear from cisplatin (CDDP)-mediated ototoxicity without affecting antitumor efficacy in vitro.
Synthesis, dopamine D-2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl)propyl]-1H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1H-benzimidazole and their analogs
5-[3-(4-Arylpiperazin-1-yl)propyl]-1H-benzimidazoles and 5-[2-(4-aryipiperazin-1-yl)ethoxy]-1H-benzimidazoles were synthesized and their affinity for the D-1, D-2 and 5-HT1A, receptors examined. They expressed a rather high affinity for the D-2 doparnine receptor. The main features of ligand-D-2 receptor interactions revealed by docking analyses were: salt bridge between piperazine ring protonated N-1 and Asp 86, hydrogen bonds of ligand bezimidazole part with Ser 141, Ser 122 and His 189, edge-to-face interactions of arylpiperazine aromatic ring with Phe 178, Tyr 216 and Trp 182 and hydrogen bond between ethereal oxygen in ethylenoxy ligands and hydrogen of Phe 185 or Trp 115. The most active 5-{2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethoxy}-1,3-di hydro-2H-benzimidazole-2-thione (27) has a maximal number of attractive interactions. A satisfactory correlation between docking of the compounds into the D-2 receptor and competition binding results was observed
Breast cancer proteomics by laser capture microdissection, sample pooling, 54 cm immobilised pH gradient isoelectric focussing, and differential iodine radioisotope detection
Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome
113 ANNEXIN A3 QUANTIFICATION FROM SUPERNATANTS OF URINE AFTER DRE PROVIDES A NOVEL AND CLINICALLY EASY AVAILABLE BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF PROSTATE CANCER
Comparative profiling of the mammalian mitochondrial proteome: multiple aconitase-2 isoforms includi
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